Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marianne Bizzozzero Hiriart"'
Autor:
Noelia P. Di Giorgio, Marianne Bizzozzero-Hiriart, Pablo N. Surkin, Esteban Repetto, María M. Bonaventura, Florencia N. Tabares, Nadia S. Bourguignon, Ayelén Converti, Juan M. Riaño Gomez, Bernhard Bettler, Victoria Lux-Lantos
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E314-E329
We developed a unique mouse lacking GABAB receptors specifically in Kiss1 cells to evaluate the impact on reproduction and metabolism. Knockout males showed a severe impact on glucose homeostasis, which worsened with aging. These results reinforce th
Publikováno v:
Neuroendocrinology. 112:998-1026
Introduction: The kisspeptin gene Kiss1 is expressed in two hypothalamic areas: anteroventral periventricular nucleus/periventricular nucleus (AVPV/PeN) and arcuate nucleus (ARC), and also in gonads. Several pieces of evidence suggests that gamma-ami
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 318(6)
Lack of GABA
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Lack of GABAB receptors in GABAB1 knockout mice decreases neonatal ARC kisspeptin 1 (Kiss1) expression in the arcuate nucleus of the hypothalamus (ARC) in females, which show impaired reproduction as adults. Our aim was to selectively impair GABAB si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf77e24f010d49156cdb432ec6dfc31
https://journals.physiology.org/doi/abs/10.1152/ajpendo.00547.2019
https://journals.physiology.org/doi/abs/10.1152/ajpendo.00547.2019
Publikováno v:
Journal of the Endocrine Society
We have previously shown that the administration of a GABAB antagonist (CGP55845) to neonatal BALB/C mice from postnatal day (PND) 2-6 significantly decreased arcuate nucleus (ARC) kisspeptin (Kiss1) expression in both sexes. Furthermore, this neonat
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Neuroendocrine control of reproduction involves the interplay of various factors that become active at some point along development. GnRH is the main neurohormone controlling reproduction and among the most important inputs modulating GnRH synthesis/
Autor:
Paula V López, Bernhard Bettler, Carlos Libertun, Pablo N Surkin, Marianne Bizzozzero Hiriart, Victoria Lux-Lantos, Verónica B Dorfman, Noelia Paula Di Giorgio, Nadia Bourguignon
Publikováno v:
Journal of neuroendocrinologyREFERENCES. 31(8)
Female mice lacking GABAB receptors, GABAB1KO, show disrupted oestrous cycles, reduced pregnancies and increased hypothalamic Gnrh1 mRNA expression, whereas anteroventral periventricular/periventricular preoptic nucleus (AVPV/PeN) Kiss1 mRNA was not