Neoadjuvant intratumoral influenza vaccine treatment in patients with proficient mismatch repair colorectal cancer leads to increased tumor infiltration of CD8+ T cells and upregulation of PD-L1: a phase 1/2 clinical trial

Autor: Mikail Gögenur, Lukas Balsevicius, Mustafa Bulut, Nesibe Colak, Tobias Freyberg Justesen, Anne-Marie Kanstrup Fiehn, Marianne Bøgevang Jensen, Kathrine Høst-Rasmussen, Britt Cappelen, Shruti Gaggar, Asma Tajik, Jawad Ahmad Zahid, Astrid Louise Bjørn Bennedsen, Tommaso Del Buono D’Ondes, Hans Raskov, Susanne Gjørup Sækmose, Lasse Bremholm Hansen, Ali Salanti, Susanne Brix, Ismail Gögenur

Publikováno v: Gögenur, M, Balsevicius, L, Bulut, M, Colak, N, Justesen, T F, Fiehn, A-M K, Jensen, M B, Høst-Rasmussen, K, Cappelen, B, Gaggar, S, Tajik, A, Zahid, J A, Bennedsen, A L B, D'Ondes, T D B, Raskov, H, Sækmose, S G, Hansen, L B, Salanti, A, Brix, S & Gögenur, I 2023, ' Neoadjuvant intratumoral influenza vaccine treatment in patients with proficient mismatch repair colorectal cancer leads to increased tumor infiltration of CD8+ T cells and upregulation of PD-L1: a phase 1/2 clinical trial ', Journal for ImmunoTherapy of Cancer, vol. 11, no. 5, e006774 . https://doi.org/10.1136/jitc-2023-006774

BackgroundIn colorectal cancer, the effects of immune checkpoint inhibitors are mostly limited to patients with deficient mismatch repair tumors, characterized by a high grade infiltration of CD8+T cells. Interventions aimed at increasing intratumora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f85e690fee350b864f70c666637cc7
https://orbit.dtu.dk/en/publications/53ac1b78-d29d-4cff-95bd-e42a69c92f71