Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marianne A. Mihalyo"'
Autor:
Adam T. Hagymasi, Marie-Clare St. Rose, Robert B. Clark, Adam J. Adler, Marianne A. Mihalyo, Harry Z. Qui, Suman Bandyopadhyay
Publikováno v:
The Journal of Immunology. 183:4975-4983
Cbl-b is an E3 ubiquitin ligase that limits Ag responsiveness in T cells by targeting TCR-inducible signaling molecules. Cbl-b deficiency thus renders T cells hyperresponsive to antigenic stimulation and predisposes individuals toward developing auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9e4a22ea81c20ca0fca664bb6b15100
https://doi.org/10.4049/jimmunol.0901243
https://doi.org/10.4049/jimmunol.0901243
Autor:
Marianne A. Mihalyo, Robert S. Mittler, Harry Z. Qui, Aaron M. Slaiby, Suman Bandyopadhyay, Adam J. Adler, Hector L. Aguila, Adam T. Hagymasi, Meixiao Long, Anthony T. Vella
Publikováno v:
The Journal of Immunology. 181:7728-7737
We compared how CD4 vs CD8 cells attain the capacity to express the effector cytokine IFN-γ under both immunogenic and tolerogenic conditions. Although the Ifng gene locus was epigenetically repressed in naive Ag-inexperienced CD4 cells, it had alre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb4c475551fceedc30f444745917092
https://doi.org/10.4049/jimmunol.181.11.7728
https://doi.org/10.4049/jimmunol.181.11.7728
Autor:
Suman Bandyopadhyay, Adam T. Hagymasi, Meixiao Long, Aaron M. Slaiby, Anthony T. Vella, Marianne A. Mihalyo, Adam J. Adler, Shuang Wu
Publikováno v:
The Journal of Immunology. 179:5669-5677
When naive CD4+ Th cells encounter cognate pathogen-derived Ags they expand and develop the capacity to express the appropriate effector cytokines for neutralizing the pathogen. Central to this differentiation process are epigenetic modifications wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5e31a485df2da9cc54df158ad96ec8c
https://doi.org/10.4049/jimmunol.179.9.5669
https://doi.org/10.4049/jimmunol.179.9.5669
Autor:
Stephen K. Wikel, V. D. Boppana, Marianne A. Mihalyo, U. U. Müller-Doblies, Sarah Sollid Maxwell, Anthony T. Vella, Stephen J. McSorley, Adam J. Adler
Publikováno v:
Parasite Immunology. 29:485-499
SUMMARY Effects of tick feeding on an early antigen-specific T cell response were studied by monitoring a clonotypic population of adoptively transferred T cell receptor (TCR) transgenic CD4 cells responding to a tick-associated antigen. When recipie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b39d1761b74ffd6d38bbcc62289ad5
https://doi.org/10.1111/j.1365-3024.2007.00966.x
https://doi.org/10.1111/j.1365-3024.2007.00966.x
Autor:
Aaron M. Slaiby, Marianne A. Mihalyo, Adam J. Adler, Harry Z. Qui, Leo Lefrançois, David J. Zammit, Adam T. Hagymasi
Publikováno v:
The Journal of Immunology. 179:1524-1531
Bone marrow-derived APC are critical for both priming effector/memory T cell responses to pathogens and inducing peripheral tolerance in self-reactive T cells. In particular, dendritic cells (DC) can acquire peripheral self-Ags under steady state con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d880534d891473d5742cb9047cc16044
https://doi.org/10.4049/jimmunol.179.3.1524
https://doi.org/10.4049/jimmunol.179.3.1524
Autor:
Adam J. Adler, Marianne A. Mihalyo, Charles G. Drake, Adam T. Hagymasi, Amy D. H. Doody, Joseph T. Kovalchin
Publikováno v:
The Journal of Immunology. 172:6087-6092
The ability of mature T lymphocytes to develop effector capacity after encounter with cognate Ag is generally dependent upon inflammatory signals associated with infection that induce dendritic cell activation/maturation. These inflammatory signals c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f0d1688eb53a6ea1ffd08e50a2a4e6
https://doi.org/10.4049/jimmunol.172.10.6087
https://doi.org/10.4049/jimmunol.172.10.6087
Autor:
Marianne A. Mihalyo, Elizabeth C. Nowak, Yi Yang, Amy D. H. Doody, Jeremy P. McAleer, Adam J. Adler, Meixiao Long
Publikováno v:
The Journal of Immunology. 172:5338-5345
The development of T cell tolerance directed toward tumor-associated Ags can limit the repertoire of functional tumor-reactive T cells, thus impairing the ability of vaccines to elicit effective antitumor immunity. Adoptive immunotherapy strategies u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9627dae85f79174d73f910ec70f12793
https://doi.org/10.4049/jimmunol.172.9.5338
https://doi.org/10.4049/jimmunol.172.9.5338
Publikováno v:
The Journal of Immunology. 169:3622-3629
It has long been established that exposure of naive T cells to specific Ag in the absence of adjuvant leads to tolerization. Nonetheless, the potential of effector CD4 cells to be tolerized has been less well characterized. To address this issue, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23cee88a64cb1c8bb28b53b99cb81943
https://doi.org/10.4049/jimmunol.169.7.3622
https://doi.org/10.4049/jimmunol.169.7.3622
Publikováno v:
The Journal of Immunology. 168:5573-5581
Bone marrow-derived APCs present both parenchymal-self and pathogen-derived Ags in a manner that elicits either T cell tolerization or immunity, respectively. To study the parameters that confer tolerogenic vs immunogenic APC function we used an adop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0a177134b3f6f853aad2f507af0d1d
https://doi.org/10.4049/jimmunol.168.11.5573
https://doi.org/10.4049/jimmunol.168.11.5573
Publikováno v:
The Prostate. 67(5)
BACKGROUND Prostate cancer promotes the development of T cell tolerance towards prostatic antigens, potentially limiting the efficacy of prostate cancer vaccines targeting these antigens. Here, we sought to determine the stage of disease progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acda1520575df6f8e1faa32dc0f51b03
https://pubmed.ncbi.nlm.nih.gov/17221844
https://pubmed.ncbi.nlm.nih.gov/17221844