Ex vivo innate responses to particulate matter from livestock farms in asthma patients and healthy individuals

Autor: Linsey E. S. de Groot, Dingyu Liu, Barbara S. Dierdorp, Niki Fens, Marianne A. van de Pol, Peter J. Sterk, Wim Kulik, Miriam E. Gerlofs-Nijland, Flemming R. Cassee, Elena Pinelli, René Lutter

Publikováno v: Environmental Health, Vol 19, Iss 1, Pp 1-10 (2020)

Abstract Background Asthma patients suffer from periodic acute worsening of symptoms (i.e. loss of asthma control or exacerbations), triggered by a variety of exogenous stimuli. With the growing awareness that air pollutants impact respiratory diseas

Externí odkaz: https://doaj.org/article/fd805339cf214428b826258cf765ecc1

LSC - 2019 - Anti-IL5 in mild asthma alters rhinovirus-induced macrophage, B cell and neutrophil responses

Autor: René Lutter, Koen van der Sluijs, Peter J. Sterk, Barbara Smids, Marianne A. van de Pol, Peter I. Bonta, Koos Zwinderman, Tamara Dekker, Annemiek Dijkhuis, Yanaika S. Sabogal Piñeros, Lara Ravanetti, Suzanne M. Bal, Paul Brinkman, Christof J. Majoor

Publikováno v: Airway cell biology and immunopathology.

Eosinophils are considered to drive the pathophysiology in asthma and therefore treatment is focused on reducing eosinophil numbers. Mepolizumab, a humanized monoclonal antibody that neutralizes interleukin 5 (IL-5), efficiently attenuates both syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31b519d5168516eb3a04530c841bb934
https://doi.org/10.1183/13993003.congress-2019.pa5200

Anti-IL5 in mild asthma alters rhinovirus-induced macrophage, B cell and neutrophil responses

Autor: René Lutter, Marianne A. van de Pol, Peter J. Sterk, Yanaika S. Sabogal Piñeros, Annemiek Dijkhuis, Koen van der Sluijs, Christof J. Majoor, Suzanne M. Bal, Lara Ravanetti, Peter I. Bonta, Paul Brinkman, Koos Zwinderman, Tamara Dekker, Barbara Smids

Publikováno v: Airway Cell Biology and Immunopathology.

Eosinophils are considered to drive the pathophysiology in asthma and therefore treatment is focused on reducing eosinophil numbers. Mepolizumab, a humanized monoclonal antibody that neutralizes interleukin 5 (IL-5), efficiently attenuates both syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a2e4c33afa6b92ca8340cc53333aa65
https://doi.org/10.1183/23120541.lungscienceconference-2019.yi03

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum -omics

Autor: Hugo H. Knobel, Koos Zwinderman, Anton Vink, Laurie Pahus, Elisabeth H. Bel, Wim van Aalderenm, Massimo Caruso, Marianne A. van de Pol, Lorraine Hewitt, David Balgoma, Jilaiha Gent, Paul Skipp, Sally Meah, Grazyna Bochenek, Martina Gahlemann, Xugang Hu, Graham Roberts, Stephen J. Fowler, Aleksandra Draper, Jon R Konradsen, Craig E. Wheelock, Philips Monk, Roelinde Middelveld, Päivi Söderman, Stelios Pavlidis, João P. Carvalho da Purfição Rocha, Caroline Smith, Alan J. Knox, Doroteya Staykova, Ildiko Horvath, Nadia Mores, Christophe von Garnier, Frans Wald, Uruj Hoda, Giuseppe Santini, Anne Petrén, Thomas Sandström, Alexander Mazein, Tamara Dekker, Ana R. Sousa, Andrea Maiser, Zsoka Weiszhart, Wolfgang Seibold, Susanna Palkonnen, Johan Kolmert, Cristina Gómez, Marco Sentoninco, Nancy Peffer, Anna James, Ingrid Delin, Montse Miralpeix, Antonios Aliprantis, Annemiek Dijkhuis, Amanda Roberts, Clare S. Murray, Lara Ravanetti, Yike Guo, Jenny Versnel, Richard Hu, Saeeda Lone-Satif, Jonathan Ward, Martine Robberechts, René Lutter, Linn Krueger, Antonio Pacino, Arnaldo D'Amico, Jans Hohlfeld, Scott Wagers, Neil Fitch, Pippa Powel, Matthew J. Loza, Karin Strandberg, Damijan Erzen, H. Ahmed, Per Bakke, Neil Gozzard, David Gibeon, Arianne Wagerner, Kerry Gove, Siân Williams, Ann Berglind, Rosalia Emma, Bob Thornton, Val Hudson, Elizabeth Yeyashingham, John Haughney, Ann-Sofie Lantz, Kjell Alving, Bart N. Lambrecht, Marek Sanak, Lilla Tamasi, Nadja Hawwa Vissing, Katja Nething, Barbro Dahlén, Jacek Musiał, Pim de Boer, Marcus O.D. Sjödin, Sarah Masefield, Marleen van Geest, Maciej Kupczyk, Peter H. Howarth, Alix Berton, Peter J. Sterk, David Myles, Peter Nilsson, Emma Ray, Ian M. Adcock, Pascal Chanez, Christos Rossios, Paolo Montuschi, Inge De Lepeleire, Armin Braun, Juliette Kamphuis, Davide Campagna, Salvatore Valente, Kees van Drunen, Urs Frey, Philipp Badorek, Ralf Sigmund, Malayka Rahman-Amin, Maria Mikus, James P.R. Schofield, Simone Hashimoto, Marton Szentkereszty, Gabriella Galffy, Lisa Marouzet, Barbara Smids, L. Larsson, Louise Fleming, Corinna Schoelch, Leanne Metcalf, Ashley Woosdcock, Anthony D. Postle, Maxim Kots, Sven-Erik Dahlén, J. M. Edwards, J.C. Smith, Gunilla Hedlin, Breda Flood, Veit J. Erpenbeck, Wen Yu, Susan J. Wilson, Jeanette Bigler, Jorge De Alba, Leon Carayannopoulos, Kristiane Wetzel, Klaus Fichtner, Paul Brinkman, Cecile T.J. Holweg, David Supple, Romanas Chaleckis, Coen Wiegman, Anthony Rowe, Hans Bisgaard, Annelie F. Behndig, Joost Brandsma, Richard G. Knowles, Jorge Beleta, Scott Kuo, Katherine M. Smith, Sandy Pink, Pieter-Paul Hekking, An Bautmans, Ben Nicholas, Kathrin Riemann, Michael Rutgers, Leanne Reynolds, Adesimbo Sogbesan, Dominic Burg, Aruna T. Bansal, Ulf Nihlen, Dyson Kerry, Ioannis Pandis, Julie Corfield, Björn Nordlund, Shama Naz, Wilhelm Zetterquist, Diane Lefaudeux, Xian Yang, Clair Barber, Kirsty E. Russell, Andrew Menzies-Gow, Dominic E. Shaw, Patrick Dennison, Elisabeth Henriksson, John G. Matthews, Tim Higgenbottam, Ratko Djukanovic, Charles Auffray, Kai Sun, Amphun Chaiboonchoe, Jonathan Thorsen, Nikos Lazarinis, Samantha Walker, John-Olof Thörngren, Frédéric Baribaud, Florian Singer, Klaus Bøonnelykke, John H. Riley, Magnus Ericsson, Sile Hu, Jørgen Vestbo, Bertrand De Meulder, Kamran Tariq, Maria Gerhardsson de Verdier, Stacey N. Reinke, Navin Rao, Trevor Garret, Norbert Krug, Michael Boedigheimer, Chris Compton, Cornelia Faulenbach, Hector Gallart, Matthias Klüglich, Caroline Mathon, Giorgio Pennazza, Kian Fan Chung, Thomas Geiser, Jörgen Östling, Courtney Coleman, Erika Kennington, Nora Adriaens, Jane Martin

Publikováno v: Journal of allergy and clinical immunology, 139(6), 1797-1807. Mosby Inc.
Lefaudeux, D, De Meulder, B, Loza, M J, Peffer, N, Rowe, A, Baribaud, F, Bansal, A T, Lutter, R, Sousa, A R, Corfield, J, Pandis, I, Bakke, P S, Caruso, M, Chanez, P, Dahlén, S-E, Fleming, L J, Fowler, S, Horvath, I, Krug, N, Montuschi, P, Sanak, M, Sandstrom, T, Shaw, D E, Singer, F, Sterk, P J, Roberts, G, Adcock, I M, Djukanovic, R, Auffray, C, Chung, K F & U-BIOPRED Study Group 2017, ' U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics ', Journal of Allergy and Clinical Immunology, vol. 139, no. 6, pp. 1797 . https://doi.org/10.1016/j.jaci.2016.08.048, https://doi.org/10.1016/j.jaci.2016.08.048

BACKGROUND: Asthma is a heterogeneous disease in which there is a differential response to asthma treatments. This heterogeneity needs to be evaluated so that a personalised management approach can be provided.OBJECTIVES: We stratified patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb05fd5f8f224a60a64676698b62ac
https://ruj.uj.edu.pl/xmlui/handle/item/138911

LSC Abstract – Identifying biomarkers of loss of control/exacerbations in asthma from exhaled breath

Autor: Peter J. Sterk, Sinha Anirban, Paul Brinkman, Niki Fens, Marije G Gerritsen, Marianne A. van de Pol

Publikováno v: ERS Lung Science Conference 2016.

Introduction: Exacerbations/loss of control (LOC) represent the major burden in asthma care and management. These events are clinically manifested by changes in symptoms and lung function, which are associated with changes in biomarkers related to ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7d4045a764b4d4bcc48d627fbbb162f
https://doi.org/10.1183/13993003.congress-2016.yi4