Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Marianne, Tiainen"'
Autor:
Niklas Ekman, Marianne Tiainen, Tea Vallenius, Pekka Katajisto, Tomi P. Mäkelä, Kari Vaahtomeri, Anou Londesborough
Publikováno v:
Development. 135:2331-2338
Inactivation of the tumor suppressor kinase Lkb1 in mice leads to vascular defects and midgestational lethality at embryonic day 9-11 (E9-E11). Here, we have used conditional targeting to investigate the defects underlying the Lkb1(-/-) phenotype. En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b995e2256c404ae81014d90a09ba9c08
https://doi.org/10.1242/dev.017038
https://doi.org/10.1242/dev.017038
Autor:
Tea Vallenius, Lina Udd, Kari Vaahtomeri, Tomi P. Mäkelä, Marianne Tiainen, Pekka Katajisto, Niklas Ekman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1775:63-75
Inactivating germline mutations in the LKB1 gene underlie Peutz-Jeghers syndrome characterized by hamartomatous polyps and an elevated risk for cancer. Recent studies suggest the involvement of LKB1 also in more common human disorders including diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285a49096db1322a7014b3e10934ff0f
https://doi.org/10.1016/j.bbcan.2006.08.003
https://doi.org/10.1016/j.bbcan.2006.08.003
Autor:
Alessandra Sacco, Angelina Felici, Marco Crescenzi, Ada Sacchi, Lucia Latella, Daniela Macera, Deborah Pajalunga, Marianne Tiainen, Marco D'Angelo
Publikováno v:
Molecular and Cellular Biology. 21:5631-5643
Terminal cell differentiation entails definitive withdrawal from the cell cycle. Although most of the cells of an adult mammal are terminally differentiated, the molecular mechanisms preserving the postmitotic state are insufficiently understood. Ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1575858f9822c96981bbe47a371205
https://doi.org/10.1128/mcb.21.16.5631-5643.2001
https://doi.org/10.1128/mcb.21.16.5631-5643.2001
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9248-9251
Germ-line mutations of LKB1 ( STK11 ) lead to Peutz–Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of Lkb1 serine/threonine kinase activity. Therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff2851656191d41d17f552f5bd191be
https://doi.org/10.1073/pnas.96.16.9248
https://doi.org/10.1073/pnas.96.16.9248
Autor:
Marianne Tiainen, O. Moesker, A. Laasonen, L. Tammilehto, Sakari Knuutila, Frans C. S. Ramaekers, Seppo Pyrhönen, Karin Mattson, Anton H. N. Hopman, Maija Wessman
Publikováno v:
Cancer Genetics and Cytogenetics. 62:171-179
We performed in situ hybridization (ISH) studies of malignant pleural mesotheliomas to detect numerical aberrations of chromosomes 1 and 7 in interphase nuclei of paraffin sections of 13 cases that had been analyzed previously by conventional karyoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d55b2157a4ced21473bc70bbdea492b
https://doi.org/10.1016/0165-4608(92)90258-a
https://doi.org/10.1016/0165-4608(92)90258-a
Autor:
P. A. Miescher, Sakari Knuutila, Ph. Beris, M. Jotterand Bellomo, Marianne Tiainen, V. Parlier
Publikováno v:
British Journal of Haematology. 81:296-304
Paroxysmal nocturnal haemoglobinuria (PNH) was diagnosed in a 20-year-old male patient who suffered from anaemia since the age of 11. Eighteen years after diagnosis, PNH transformed into refractory anaemia with ringed sideroblasts (RARS). Trisomy 8 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c676fbbf4727459731826dd40a7d98aa
https://doi.org/10.1111/j.1365-2141.1992.tb08223.x
https://doi.org/10.1111/j.1365-2141.1992.tb08223.x
Autor:
J. Rautonen, L. Tammilehto, Marianne Tiainen, Seppo Pyrhönen, Karin Mattson, A. Laasonen, Sakari Knuutila
Publikováno v:
Cancer Genetics and Cytogenetics. 60:8-13
The correlation between flow cytometric analysis and classical karyotyping was examined in malignant mesothelioma. Flow cytometry was used to determine the DNA ploidy mainly from paraffin blocks of 31 mesotheliomas, of which the S-phase fraction (SPF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8734f465c3ee98481ebeb2ac290d739
https://doi.org/10.1016/0165-4608(92)90224-v
https://doi.org/10.1016/0165-4608(92)90224-v
Autor:
J. Rautonen, Timo Tuomi, Marianne Tiainen, Seppo Pyrhönen, Karin Mattson, Sakari Knuutila, L. Tammilehto
Publikováno v:
European Journal of Cancer. 28:1373-1379
The clinical characteristics and the results of mineral fibre and cytogenetic analyses were coordinated prospectively for 41 patients with confirmed malignant pleural mesothelioma. A correlation was found between high total fibre concentration, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492a9df2e9bf8309b8d9bc466e3514e1
https://doi.org/10.1016/0959-8049(92)90523-5
https://doi.org/10.1016/0959-8049(92)90523-5
Autor:
AP Losada, Woessner S, Sakari Knuutila, HF Willard, AH Hopman, Francesc Solé, Caballin, Maija Wessman, Marianne Tiainen
Publikováno v:
ResearcherID
Interphase cytogenetics by means of in situ hybridization with the chromosome 12-specific biotinylated alpha satellite DNA probe pSP 12–1 was used for the study of trisomy 12, the most common chromosomal abnormality in chronic lymphocytic leukemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250a7bfea39ace08d3eb4554902193c8
https://doi.org/10.1182/blood.v78.3.775.bloodjournal783775
https://doi.org/10.1182/blood.v78.3.775.bloodjournal783775
Publikováno v:
Duodecim; laaketieteellinen aikakauskirja. 120(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0614abbc25001b15f09d12679a3811d
https://pubmed.ncbi.nlm.nih.gov/15327080
https://pubmed.ncbi.nlm.nih.gov/15327080