Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Marianne, Sinn"'
Autor:
Joao Gorgulho, Sven H. Loosen, Ramsha Masood, Franziska Giehren, Francesca Pagani, Gustav Buescher, Lorenz Kocheise, Vincent Joerg, Constantin Schmidt, Kornelius Schulze, Christoph Roderburg, Eva Kinkel, Britta Fritzsche, Simon Wehmeyer, Benjamin Schmidt, Paul Kachel, Christina Rolling, Julian Götze, Alina Busch, Marianne Sinn, Thais Pereira-Veiga, Harriet Wikman, Maria Geffken, Sven Peine, Urte Matschl, Markus Altfeld, Samuel Huber, Ansgar W. Lohse, Fabian Beier, Tim H. Brümmendorf, Carsten Bokemeyer, Tom Luedde, Johann von Felden
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background The major breakthrough in cancer therapy with immune checkpoint inhibitors (ICIs) has highlighted the important role of immune checkpoints in antitumoral immunity. However, most patients do not achieve durable responses, making bi
Externí odkaz:
https://doaj.org/article/c2fb5d5ae25641debf5ff764186a0fca
Autor:
Jia Rao, Marianne Sinn, Uwe Pelzer, Hanno Riess, Helmut Oettle, Ihsan E Demir, Helmut Friess, Carsten Jäger, Katja Steiger, Alexander Muckenhuber
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 3, Pp n/a-n/a (2024)
Abstract Even after decades of research, pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease and responses to conventional treatments remain mostly poor. Subclassification of PDAC into distinct biological subtypes has been propose
Externí odkaz:
https://doaj.org/article/ebc9a9694d4e4a05a5d62bac932a1b24
Autor:
Phyllis F. Cheung, JiaJin Yang, Rui Fang, Arianna Borgers, Kirsten Krengel, Anne Stoffel, Kristina Althoff, Chi Wai Yip, Elaine H. L. Siu, Linda W. C. Ng, Karl S. Lang, Lamin B. Cham, Daniel R. Engel, Camille Soun, Igor Cima, Björn Scheffler, Jana K. Striefler, Marianne Sinn, Marcus Bahra, Uwe Pelzer, Helmut Oettle, Peter Markus, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Konstantinos Savvatakis, Sven-Thorsten Liffers, Smiths S. Lueong, Christian Neander, Anna Bazarna, Xin Zhang, Annette Paschen, Howard C. Crawford, Anthony W. H. Chan, Siu Tim Cheung, Jens T. Siveke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation o
Externí odkaz:
https://doaj.org/article/c9aa189db2194c2eba13f30f461a6fdd
Autor:
Julian Götze, Christine Nitschke, Faik G. Uzunoglu, Klaus Pantel, Marianne Sinn, Harriet Wikman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The extremely poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) has remained unchanged for decades. As a hallmark of PDAC histology, the distinct desmoplastic response in the tumor microenvironment is considered a key factor ex
Externí odkaz:
https://doaj.org/article/467dabdb5eba492bbdb914f65655bd4b
Autor:
Christine Nitschke, Benedikt Markmann, Leonie Konczalla, Jolanthe Kropidlowski, Thais Pereira-Veiga, Pasquale Scognamiglio, Martin Schönrock, Marianne Sinn, Marie Tölle, Jakob Izbicki, Klaus Pantel, Faik G. Uzunoglu, Harriet Wikman
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2955 (2022)
Background: Circulating Cancer Associated Macrophage-like cells (CAMLs) have been described as novel liquid biopsy analytes and unfavorable prognostic markers in some tumor entities, with scarce data for Pancreatic Ductal Adenocarcinomas (PDAC). Meth
Externí odkaz:
https://doaj.org/article/cd0cee1a519f47e4ae0d74c5b114a9fb
Autor:
Jana Käthe Striefler, Hanno Riess, Philipp Lohneis, Sven Bischoff, Annika Kurreck, Dominik Paul Modest, Marcus Bahra, Helmut Oettle, Marianne Sinn, Henrik Bläker, Carsten Denkert, Sebastian Stintzing, Bruno Valentin Sinn, Uwe Pelzer
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundThe Mucin-family protein, MUC1, impacts on carcinogenesis and tumor invasion. We evaluated the impact of MUC1 expression on outcome in a cohort of 158 patients with resected pancreatic ductal adenocarcinomas (PDAC) in the CONKO-001 study (a
Externí odkaz:
https://doaj.org/article/c46c33f0aa6a4faeb2215126a5c9b5db
Autor:
Christian Benzing, MD, Fritz Klein, MD, Uwe Pelzer, MD, Marianne Sinn, MD, Johann Pratschke, MD, Marcus Bahra, MD
Publikováno v:
Journal of Pancreatology, Vol 2, Iss 3, Pp 107-112 (2019)
Abstract. Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by an aggressive tumor behavior. The present analysis seeks to identify and analyze a cohort that meets criteria for “inflammatory” PDAC (IPDAC). All patients who und
Externí odkaz:
https://doaj.org/article/02743564565a4f729da7be63723a641d
Autor:
Michael Bitzer, Sabrina Groß, Jörg Albert, Judit Boda-Heggemann, Thomas Brunner, Reiner Caspari, Enrico De Toni, Frank Dombrowski, Matthias Evert, Andreas Geier, Eleni Gkika, Martin Götz, Thomas Helmberger, Ralf-Thorsten Hoffmann, Peter Huppert, Achim Kautz, David Krug, Christian La Fougère, Hauke Lang, Philipp Lenz, Tom Lüdde, Andreas Mahnken, Silvio Nadalin, Hoa Huu Phuc Nguyen, Johann Ockenga, Karl Oldhafer, Philipp Paprottka, Philippe Pereira, Thorsten Persigehl, Ruben Plentz, Jürgen Pohl, Heinrich Recken, Peter Reimer, Jutta Riemer, Ulrike Ritterbusch, Elke Roeb, Jörn Rüssel, Barbara Schellhaas, Peter Schirmacher, Hans Jürgen Schlitt, Irene Schmid, Andreas Schuler, Daniel Seehofer, Marianne Sinn, Andreas Stengel, Christoph Stoll, Andrea Tannapfel, Anne Taubert, Reina Tholen, Jörg Trojan, Ingo van Thiel, Arndt Vogel, Thomas Vogl, Frank Wacker, Oliver Waidmann, Heiner Wedemeyer, Henning Wege, Dane Wildner, Marcus-Alexander Wörns, Peter Galle, Nisar Malek
Publikováno v:
Zeitschrift für Gastroenterologie. 61:420-440
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f130b594ed6b982f1b0e44a58b394e3
https://doi.org/10.1055/a-2026-1277
https://doi.org/10.1055/a-2026-1277
Publikováno v:
B&G Bewegungstherapie und Gesundheitssport. 39:49-55
ZusammenfassungKrebserkrankungen sind nach Herz-Kreislauf-Erkrankungen die zweithäufigste Todesursache in Deutschland. Die Zahl der Krebsüberlebenden, sogenannten „Cancer Survivors“, nimmt aufgrund verbesserter Früherkennungsmethoden und Thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d297eb78570be048248dc1dff759c5bd
https://doi.org/10.1055/a-2023-9393
https://doi.org/10.1055/a-2023-9393
Autor:
Joseph Tintelnot, Yang Xu, Till R. Lesker, Martin Schönlein, Leonie Konczalla, Anastasios D. Giannou, Penelope Pelczar, Dominik Kylies, Victor G. Puelles, Agata A. Bielecka, Manuela Peschka, Filippo Cortesi, Kristoffer Riecken, Maximilian Jung, Lena Amend, Tobias S. Bröring, Marija Trajkovic-Arsic, Jens T. Siveke, Thomas Renné, Danmei Zhang, Stefan Boeck, Till Strowig, Faik G. Uzunoglu, Cenap Güngör, Alexander Stein, Jakob R. Izbicki, Carsten Bokemeyer, Marianne Sinn, Alec C. Kimmelman, Samuel Huber, Nicola Gagliani
Publikováno v:
Tintelnot, J, Xu, Y, Lesker, T R, Schönlein, M, Konczalla, L, Giannou, A D, Pelczar, P, Kylies, D, Puelles, V G, Bielecka, A A, Peschka, M, Cortesi, F, Riecken, K, Jung, M, Amend, L, Bröring, T S, Trajkovic-Arsic, M, Siveke, J T, Renné, T, Zhang, D, Boeck, S, Strowig, T, Uzunoglu, F G, Güngör, C, Stein, A, Izbicki, J R, Bokemeyer, C, Sinn, M, Kimmelman, A C, Huber, S & Gagliani, N 2023, ' Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer ', Nature, vol. 615, no. 7950, pp. 168-174 . https://doi.org/10.1038/s41586-023-05728-y
Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment1,2. Less than half of all patients respond to the primary treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6958462eedf5593c667bb2b17214d3f0
https://doi.org/10.1038/s41586-023-05728-y
https://doi.org/10.1038/s41586-023-05728-y