Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Marianne, Koschel"'
Autor:
Cécile Guth, Pia Philippa Schumacher, Archena Vijayakumar, Hannah Borgmann, Helene Balles, Marianne Koschel, Frederic Risch, Benjamin Lenz, Achim Hoerauf, Marc P. Hübner, Jesuthas Ajendra
Publikováno v:
Journal of Innate Immunity, Vol 16, Iss 1, Pp 159-172 (2024)
Introduction: Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a mo
Externí odkaz:
https://doaj.org/article/3ff8781942c543c7a1454539b861e869
Autor:
Shrilakshmi Hegde, Amy E. Marriott, Nicolas Pionnier, Andrew Steven, Christina Bulman, Emma Gunderson, Ian Vogel, Marianne Koschel, Alexandra Ehrens, Sara Lustigman, Denis Voronin, Nancy Tricoche, Achim Hoerauf, Marc P. Hübner, Judy Sakanari, Ghaith Aljayyoussi, Fabian Gusovsky, Jessica Dagley, David W. Hong, Paul O'Neill, Steven A. Ward, Mark J. Taylor, Joseph D. Turner
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Lymphatic filariasis and onchocerciasis are two major neglected tropical diseases that are responsible for causing severe disability in 50 million people worldwide, whilst veterinary filariasis (heartworm) is a potentially lethal parasitic infection
Externí odkaz:
https://doaj.org/article/7818521273b4477987c6341e4921c6ea
Autor:
Frederic Risch, Johanna F. Scheunemann, Julia J. Reichwald, Benjamin Lenz, Alexandra Ehrens, Joséphine Gal, Frédéric Fercoq, Marianne Koschel, Martina Fendler, Achim Hoerauf, Coralie Martin, Marc P. Hübner
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal candidate with improved oral availability compared to flubendazole (FBZ), and OXF is currently und
Externí odkaz:
https://doaj.org/article/50e2c8efd04044ce9bfe78ec3cd8f293
Autor:
Natalie Hawryluk, Li Zhiru, Clotilde Carlow, Suzanne Gokool, Simon Townson, Tamara Kreiss, Agnieszka Chojnowski, Monika Prorok, John Siekierka, Alexandra Ehrens, Marianne Koschel, Nathaly Lhermitte-Vallarino, Coralie Martin, Achim Hoerauf, Geraldine Hernandez, Stacie Canan, Vikram Khetani, Jerome Zeldis, Sabine Specht, Marc P. Hübner, Ivan Scandale
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 19, Iss , Pp 89-97 (2022)
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting over 86 million people worldwide. To control and more rapidly eliminate onchocerciasis requires treatm
Externí odkaz:
https://doaj.org/article/68b02e6e71f1432399da4c59040a7b3a
Autor:
Johanna F. Scheunemann, Frederic Risch, Julia J. Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J. Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe, Eicke Latz, Christoph Coch, Gunther Hartmann, Beatrix Schumak, Achim Hoerauf, Marc P. Hübner
Publikováno v:
Vaccines, Vol 11, Iss 5, p 966 (2023)
More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against filarial infections. Previous studies indicated that vaccination with irradiated infective
Externí odkaz:
https://doaj.org/article/b87d9cd8fe334b3eaac4ac43de97300f
Autor:
Marc P. Hübner, Emma Gunderson, Ian Vogel, Christina A. Bulman, K.C. Lim, Marianne Koschel, Alexandra Ehrens, Stefan J. Frohberger, Martina Fendler, Nancy Tricoche, Denis Voronin, Andrew Steven, Victor Chi, Malina A. Bakowski, Ashley K. Woods, H. Michael Petrassi, Case W. McNamara, Brenda Beerntsen, Laura Chappell, William Sullivan, Mark J. Taylor, Joseph D. Turner, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 12, Iss , Pp 18-27 (2020)
The quinazolines CBR417 and CBR490 were previously shown to be potent anti-wolbachials that deplete Wolbachia endosymbionts of filarial nematodes and present promising pre-clinical candidates for human filarial diseases such as onchocerciasis. In the
Externí odkaz:
https://doaj.org/article/ae0698b9586a42138cd1a78a22ad6053
Autor:
Andrea Schiefer, Marc P Hübner, Anna Krome, Christine Lämmer, Alexandra Ehrens, Tilman Aden, Marianne Koschel, Helene Neufeld, Lillibeth Chaverra-Muñoz, Rolf Jansen, Stefan Kehraus, Gabriele M König, Domen Pogorevc, Rolf Müller, Marc Stadler, Stephan Hüttel, Thomas Hesterkamp, Karl Wagner, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008930 (2020)
Current efforts to eliminate the neglected tropical diseases onchocerciasis and lymphatic filariasis, caused by the filarial nematodes Onchocerca volvulus and Wuchereria bancrofti or Brugia spp., respectively, are hampered by lack of a short-course m
Externí odkaz:
https://doaj.org/article/d4370a71cad149209e66761eb918df85
Autor:
Marc P Hübner, Coralie Martin, Sabine Specht, Marianne Koschel, Bettina Dubben, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Dominique Struever, Edward Mitre, Nathaly Vallarino-Lhermitte, Suzanne Gokool, Sara Lustigman, Manfred Schneider, Simon Townson, Achim Hoerauf, Ivan Scandale
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008427 (2020)
A major impediment to eliminate lymphatic filariasis and onchocerciasis is the lack of effective short-course macrofilaricidal drugs or regimens that are proven to be safe for both infections. In this study we tested oxfendazole, an anthelmintic show
Externí odkaz:
https://doaj.org/article/82f0088c9fe348ba9d0ddb5af5d88a13
Autor:
Jayagopi Surendar, Indulekha Karunakaran, Stefan J. Frohberger, Marianne Koschel, Achim Hoerauf, Marc P. Hübner
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Even after successful weight reduction, obese adults tend to quickly regain the lost weight. This raises the question of whether weight loss improves the underlying chronic adipose tissue inflammation characteristic of obesity. In order to improve ou
Externí odkaz:
https://doaj.org/article/e1df77773c06416abad261c1d608e96e
Autor:
Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that ta
Externí odkaz:
https://doaj.org/article/dec6d4c0192a4b7f912f2690a17c0fac