Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

Autor: Nigel Davies, Daniel Hovdal, Nicholas Edmunds, Peter Nordberg, Anders Dahlén, Aleksandra Dabkowska, Marianna Yanez Arteta, Aurel Radulescu, Tomas Kjellman, Andreas Höijer, Frank Seeliger, Elin Holmedal, Elisabeth Andihn, Nils Bergenhem, Ann-Sofie Sandinge, Camilla Johansson, Leif Hultin, Marie Johansson, Johnny Lindqvist, Liselotte Björsson, Yujia Jing, Stefano Bartesaghi, Lennart Lindfors, Shalini Andersson

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 369-384 (2021)

Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of patient se

Externí odkaz: https://doaj.org/article/0ab815ddadcf443ab6a9364825393a93

Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

Autor: Camilla Johansson, Johnny Lindqvist, Lennart Lindfors, Peter Nordberg, Andreas Höijer, Elin Holmedal, Ann-Sofie Sandinge, Marianna Yanez Arteta, Anders Dahlén, Yujia Jing, Elisabeth Andihn, Aurel Radulescu, Leif Hultin, Nicholas Edmunds, Shalini Andersson, Frank Seeliger, Daniel Hovdal, Nils Bergenhem, Nigel Davies, Aleksandra P. Dabkowska, Liselotte Björsson, Stefano Bartesaghi, Tomas Kjellman, Marie Johansson

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 369-384 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy / Nucleic Acids 24, 369-384 (2021). doi:10.1016/j.omtn.2021.03.008

Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of patient se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee74a175a374710935a56c3841d23d0
http://www.sciencedirect.com/science/article/pii/S2162253121000792

Quantitative intracellular retention of delivered RNAs through optimized cell fixation and immunostaining

Autor: Prasath Paramasivam, Martin Stöter, Eloina Corradi, Irene Dalla Costa, Andreas Höijer, Stefano Bartesaghi, Alan Sabirsh, Lennart Lindfors, Marianna Yanez Arteta, Peter Nordberg, Shalini Andersson, Marie-Laure Baudet, Marc Bickle, Marino Zerial

Detection of nucleic acids within subcellular compartments is key to understanding their function. Determining the intracellular distribution of nucleic acids requires quantitative retention and estimation of their association with different organell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e939bf2c106a9c7f3f8c033e030bb5
http://hdl.handle.net/11572/336895

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

Autor: Venkata R. Krishnamurthy, Marianna Yanez Arteta, Michael Lerche, Martine Moulin, Michael Haertlein, Christian Lang, Lennart Lindfors, V. Trevor Forsyth, Harald Pichler, Tamim A. Darwish, Robert A. Russell, Federica Sebastiani, Ryan A. Bragg, Lionel Porcar, Marité Cárdenas, Charles S. Elmore, Sarah Waldie

Publikováno v: ACS nano 15(4), 6709-6722 (2021). doi:10.1021/acsnano.0c10064
'ACS Nano ', vol: 15, pages: 6709-6722 (2021)
ACS Nano

Emerging therapeutic treatments based on the production of proteins by delivering mRNA have become increasingly important in recent times. While lipid nanoparticles (LNPs) are approved vehicles for small interfering RNA delivery, there are still chal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4e4b06ff3ca666c2ae9c5815ba89b6
https://hdl.handle.net/2128/27729

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

Autor: Noemi Szekely, Xiaoqiu Wu, Marianna Yanez Arteta, Alexander J. Kvist, Johan Bergenholtz, Lennart Lindfors, Simonetta Wallin, Stefano Bartesaghi, Tomas Kjellman, Aurel Radulescu, Aleksandra P. Dabkowska

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 115(15), E3351-E3360 (2018). doi:10.1073/pnas.1720542115

Significance mRNA treatments represent an exciting approach to cure diseases that cannot be tackled with current therapeutics. However, the delivery of mRNA to target cells remains a challenge, but among the existing alternatives, lipid nanoparticles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a9b611772405ff42c0018c3a5ee2e5
https://pubmed.ncbi.nlm.nih.gov/29588418