Výsledky vyhledávání - "Marianna Karina Gorsky"

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity

Autor: Marianna Karina Gorsky, Sylvie Burnouf, Oyinkan Sofola-Adesakin, Jacqueline Dols, Hrvoje Augustin, Carina Marianne Weigelt, Sebastian Grönke, Linda Partridge

Publikováno v: Scientific Reports
Sci Rep
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Tau is a microtubule-associated protein that is highly soluble and natively unfolded. Its dysfunction is involved in the pathogenesis of several neurodegenerative disorders including Alzheimer’s disease (AD), where it aggregates within neurons. Dec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c54139cd0f8763e497f9038226dcaf2e

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Deletion of endogenous Tau proteins is not detrimental in Drosophila

Autor: Sebastian Grönke, Pedro Martinez, Marianna Karina Gorsky, Jennifer A Werner, Sylvie Burnouf, Fiona Kerr, Hrvoje Augustin, Linda Partridge, Nazif Alic, Jacqueline Dols

Publikováno v: Scientific Reports

Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical filaments is involved in the pathogenesis of Alzheimer’s disease (AD), const

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc19277a5b06fc1e67898891b8784044
https://pubmed.ncbi.nlm.nih.gov/26976084

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Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

Autor: Eckhard Mandelkow, Jacqueline Dols, Marianna Karina Gorsky, Linda Partridge, Sylvie Burnouf

Publikováno v: Scientific Reports
Scientific reports 6(1), 22685 (2016). doi:10.1038/srep22685

Dysfunction and accumulation of the microtubule-associated human Tau (hTau) protein into intraneuronal aggregates is observed in many neurodegenerative disorders including Alzheimer’s disease (AD). Reversible lysine acetylation has recently emerged

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00241a69b9c48a44170438cbac328189
https://hdl.handle.net/21.11116/0000-000B-7191-1

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