Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Marianna G Yakubovskaya"'
Autor:
Ekaterina M Zhidkova, Evgeniya S Lylova, Alena V Savinkova, Sergey A Mertsalov, Kirill I Kirsanov, Gennady A Belitsky, Marianna G Yakubovskaya, Ekaterina A Lesovaya
Publikováno v:
Breast Cancer: Basic and Clinical Research, Vol 14 (2020)
Glucocorticoids (GCs) are stress hormones that play multiple roles in the regulation of cancer cell differentiation, apoptosis, and proliferation. Some types of cancers, such as hematological malignancies, can be effectively treated by GCs, whereas t
Externí odkaz:
https://doaj.org/article/acffbb957f7e4348834e8168b5fd0156
Autor:
Katerina Leonova, Alfiya Safina, Elimelech Nesher, Poorva Sandlesh, Rachel Pratt, Catherine Burkhart, Brittany Lipchick, Ilya Gitlin, Costakis Frangou, Igor Koman, Jianmin Wang, Kirill Kirsanov, Marianna G Yakubovskaya, Andrei V Gudkov, Katerina Gurova
Publikováno v:
eLife, Vol 7 (2018)
Cellular responses to the loss of genomic stability are well-established, while how mammalian cells respond to chromatin destabilization is largely unknown. We previously found that DNA demethylation on p53-deficient background leads to transcription
Externí odkaz:
https://doaj.org/article/88616e07b80f41b895f651a4e32753ab
Autor:
Ekaterina A. Mikhina, Daria V. Stepanycheva, Varvara P. Maksimova, Olga N. Sineva, Natalia N. Markelova, Lyubov E. Grebenkina, Ekaterina A. Lesovaya, Marianna G. Yakubovskaya, Andrey V. Matveev, Ekaterina M. Zhidkova
Publikováno v:
Molecules, Vol 29, Iss 20, p 4808 (2024)
Ribavirin and its analogues exhibit an in vitro antiproliferative effect in cancer cells. In this work, we studied the biological activities of a number of alkyl/aryloxymethyl derivatives of ribavirin’s aglycon—1,2,4-triazole-3-carboxamide. Alkyl
Externí odkaz:
https://doaj.org/article/fa50497a603441f797dcc54831c2cc78
Autor:
Ekaterina A. Lesovaya, Timur I. Fetisov, Beniamin Yu. Bokhyan, Varvara P. Maksimova, Evgeny P. Kulikov, Gennady A. Belitsky, Kirill I. Kirsanov, Marianna G. Yakubovskaya
Publikováno v:
Cells, Vol 13, Iss 20, p 1695 (2024)
Synovial sarcoma (SS) is one of the most common types of pediatric soft tissue sarcoma (STS) being far less frequent in adults. This STS type is characterized by one specific chromosomal translocation SS18-SSX and the associated changes in signaling.
Externí odkaz:
https://doaj.org/article/9ddb95398b384953a65821cc12e4ce2b
Autor:
Ekaterina M. Zhidkova, Leyla R. Tilova, Timur I. Fetisov, Kirill I. Kirsanov, Evgeny P. Kulikov, Adel D. Enikeev, Irina V. Budunova, Gennadii A. Badun, Maria G. Chernysheva, Valerii Z. Shirinian, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8904 (2024)
Glucocorticoids (GCs) are widely used for treating hematological malignancies despite their multiple adverse effects. The biological response to GCs relies on glucocorticoid receptor (GR) transrepression (TR) that mediates the anticancer effects and
Externí odkaz:
https://doaj.org/article/b75ad0ba91b04240a79d0a95e6cbc916
Autor:
Svetlana A. Dodonova, Ekaterina M. Zhidkova, Alexey A. Kryukov, Timur T. Valiev, Kirill I. Kirsanov, Evgeny P. Kulikov, Irina V. Budunova, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17537 (2023)
This review is focused on synephrine, the principal phytochemical found in bitter orange and other medicinal plants and widely used as a dietary supplement for weight loss/body fat reduction. We examine different aspects of synephrine biology, delvin
Externí odkaz:
https://doaj.org/article/5791d8ab32854df49c12abbb2de1a48b
Autor:
Natalia I. Moiseeva, Lidia A. Laletina, Timur I. Fetisov, Leyla F. Makhmudova, Angelika E. Manikaylo, Liliya Y. Fomina, Denis A. Burov, Ekaterina A. Lesovaya, Beniamin Y. Bokhyan, Victoria Y. Zinovieva, Alice S. Vilkova, Larisa V. Mekheda, Nikolay A. Kozlov, Alexander M. Scherbakov, Evgeny M. Kirilin, Gennady A. Belitsky, Marianna G. Yakubovskaya, Kirill I. Kirsanov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3183 (2022)
Chemotherapy of soft tissue sarcomas (STS) is restricted by low chemosensitivity and multiple drug resistance (MDR). The purpose of our study was the analysis of MDR mechanism in different types of STS. We assessed the expression of ABC-transporters,
Externí odkaz:
https://doaj.org/article/1319413b6ff44b868de304e03be23b79
Autor:
Roman G. Zenkov, Olga A. Vlasova, Varvara P. Maksimova, Timur I. Fetisov, Natalia Y. Karpechenko, Lidiya V. Ektova, Vera A. Eremina, Valeriia G. Popova, Olga G. Usalka, Ekaterina A. Lesovaya, Gennady A. Belitsky, Marianna G. Yakubovskaya, Kirill I. Kirsanov
Publikováno v:
Molecules, Vol 26, Iss 23, p 7329 (2021)
Novel indolocarbazole derivatives named LCS were synthesized by our research group. Two of them were selected as the most active anticancer agents in vivo. We studied the mechanisms of anticancer activity in accordance with the previously described e
Externí odkaz:
https://doaj.org/article/84e2607c91ea44b1b4fe81b35f92e38d
Autor:
Irina Budunova, Joel T. Dudley, Ben Readhead, Leo I. Gordon, Marianna G. Yakubovskaya, Gleb Baida, Anna Klopot, Kirill I. Kirsanov, Evgeny P. Kulikov, Ekaterina M. Zhidkova, Evgeniya S. Lylova, Olga V. Morozova, Alena V. Savinkova, Ekaterina A. Lesovaya
Supplementary Figures 1-9. Suppl. Fig. 1 contains quantification of Western blots. Suppl. Fig. 2 demonstrates the effect of PI3K/mTOR/Akt inhibitors on regulation of endogenous genes by Dex in CEM and Granta cells. Suppl. Fig. 3 shows cytotoxic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c808766be15b7e58d5699c5e350e51
https://doi.org/10.1158/1535-7163.22520967.v1
https://doi.org/10.1158/1535-7163.22520967.v1
Autor:
Irina Budunova, Joel T. Dudley, Ben Readhead, Leo I. Gordon, Marianna G. Yakubovskaya, Gleb Baida, Anna Klopot, Kirill I. Kirsanov, Evgeny P. Kulikov, Ekaterina M. Zhidkova, Evgeniya S. Lylova, Olga V. Morozova, Alena V. Savinkova, Ekaterina A. Lesovaya
Glucocorticoids are widely used for therapy of hematologic malignancies. Unfortunately, chronic treatment with glucocorticoids commonly leads to adverse effects including skin and muscle atrophy and osteoporosis. We found recently that REDD1 (regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25793532674771734fa0c0e0b209e4a2
https://doi.org/10.1158/1535-7163.c.6542853.v1
https://doi.org/10.1158/1535-7163.c.6542853.v1