Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Marianna Dioszegi"'
Autor:
Jun-Ichi Nezu, Michael Brandt, Rebecca Croasdale, Eike Hoffmann, Adriane Lochner, Pablo Umana, Jan Olaf Stracke, Ulrich Brinkmann, Wolfgang Schäfer, Gabrielle Heilek, Jürgen Michael Schanzer, Wilma Dormeyer, Andreas Jekle, Changhua Ji, Marianna Dioszegi, Nick Cammack, Jun Zhang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:2369-2378
In this study, we describe novel tetravalent, bispecific antibody derivatives that bind two different epitopes on the HIV coreceptor CCR5. The basic protein formats that we applied were derived from Morrison-type bispecific antibodies: whole IgGs to
Autor:
Cheng-I. Mau, Andreas Jekle, Ferenc Makra, Surya Sankuratri, Paul Weller, André deRosier, Eun Kyung Lee, Gabriel Stephen Deems, Gabrielle Heilek, David Mark Rotstein, Changhua Ji, Shelley K. Gleason, Christine E. Brotherton-Pleiss, Marianna Dioszegi, Lubov Filonova, Lina Setti, Pamela Berry, Alejandra Trejo-Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5401-5406
A novel series of CCR5 antagonists has been identified, utilizing leads from high-throughput screening which were further modified based on insights from competitor molecules. Lead optimization was pursued by balancing opposing trends of metabolic st
Autor:
David Mark Rotstein, Changhua Ji, Rama K. Kondru, Marianna Dioszegi, Surya Sankuratri, Tara Mirzadegan, Jun Zhang
Publikováno v:
Molecular Pharmacology. 73:789-800
In addition to being an important receptor in leukocyte activation and mobilization, CCR5 is the essential coreceptor for human immunodeficiency virus (HIV). A large number of small-molecule CCR5 antagonists have been reported that show potent activi
Autor:
Gabrielle Heilek-Snyder, Jun Zhang, Changhua Ji, Gunthar Achhammer, Nick Cammack, Steven Challand, Ralf Schumacher, Monika Baehner, Surya Sankuratri, Andreas Jekle, Sandra Kroetz, Michael Brandt, Lisa Zautke, Stephan Schwoerer, Marianna Dioszegi, Yun Chen
Publikováno v:
Antiviral Research. 74:125-137
To identify monoclonal antibodies (mAbs) with high potency and novel recognition sites, more than 25,000 of mouse hybridomas were screened and 4 novel anti-human CCR5 mAbs ROAb12, ROAb13, ROAb14, and ROAb18 showing potent activity in cell-cell fusion
Autor:
Changhua Ji, Nick Cammack, Eileen Rao, Jun Zhang, Marianna Dioszegi, Rama K. Kondru, André deRosier, Surya Sankuratri, Michael Brandt, Stephan Schwoerer, Eva Chan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:1386-1397
Six mouse anti-human CCR5 monoclonal antibodies (mAbs) that showed potent antiviral activities were identified from over 26,000 mouse hybridomas. The epitopes for these mAbs were determined by using various CCR5 mutants, including CCR5/CCR2B chimeras
Analyzing ligand and small molecule binding activity of solubilized GPCRs using biosensor technology
Publikováno v:
Analytical Biochemistry. 355:132-139
We used Biacore technology to measure directly the binding of natural ligands and small molecules to the chemokine receptors CXCR4 and CCR5. Both G protein-coupled receptors were solubilized from whole cell pellets and captured on antibody surfaces f
Autor:
Gabrielle Heilek, Fernando Padilla, Surya Sankuratri, Lubov Filonova, Nicole Manser, Gabriel Stephen Deems, David Mark Rotstein, André deRosier, Paul Weller, Andreas Jekle, Marianna Dioszegi, Pamela Berry, Changhua Ji
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(11)
Elaboration of our previously disclosed spiropiperidine template led to the development of a series of novel CCR5 antagonists. Results of SAR exploration and preliminary lead characterization are described.
Autor:
André deRosier, David G. Loughhead, David Mark Rotstein, Shelley K. Gleason, Eun Kyung Lee, Fernando Padilla, Lina Setti, Dick Cournoyer, Remy Lemoine, Cheng-I. Mau, Paul Weller, Andreas Jekle, Jutta Wanner, Pamela Berry, Chris Richard Melville, Marianna Dioszegi, Ann C. Petersen, Surya Sankuratri, Jason Manka, Changhua Ji, Lin Xiao-Fa, Lijing Chen, Gabrielle Heilek, Lubov Filonova
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(10)
Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. Th
Autor:
Changhua Ji, Nick Cammack, Sophie Chiu, Eileen Rao, André deRosier, Surya Sankuratri, Marianna Dioszegi, Michael Brandt, Jun Zhang
Publikováno v:
Molecular pharmacology. 72(1)
A panel of four CCR5 monoclonal antibodies (mAbs) recognizing different epitopes on CCR5 was examined in CCR5-mediated cell-cell fusion assay, alone or in combination with a variety of small molecule CCR5 antagonists. Although no antagonism was obser
Autor:
Tara Mirzadegan, Paul A. Beavis, Peter Gee, Rama K. Kondru, David C. Swinney, Marianna Dioszegi, Surya Sankuratri, Jun Zhang
Publikováno v:
The FASEB Journal. 20