Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Marianna Aprile"'
Autor:
Simona Cataldi, Marianna Aprile, Caterina Perfetto, Brice Angot, Mireille Cormont, Alfredo Ciccodicola, Jean-Francois Tanti, Valerio Costa
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151320- (2023)
Adipose tissue (AT) dysfunctions are associated with the onset of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Targeting glucose-dependent insulinotropic peptide receptor (GIPR) is a valid option to increase the efficacy of glucagon-l
Externí odkaz:
https://doaj.org/article/c2426c617b154c4cbf0f265f2bf32536
Autor:
Gianluca Fasciolo, Gaetana Napolitano, Marianna Aprile, Simona Cataldi, Valerio Costa, Maria Teresa Muscari Tomajoli, Assunta Lombardi, Sergio Di Meo, Paola Venditti
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 592 (2023)
While a low level of ROS plays a role in cellular regulatory processes, a high level can lead to oxidative stress and cellular dysfunction. Insulin resistance (IR) is one of the dysfunctions in which oxidative stress occurs and, until now, the factor
Externí odkaz:
https://doaj.org/article/989d8fc3e61c49268f391408a25aba2b
Autor:
Simona Cataldi, Mariagiovanna Tramontano, Valerio Costa, Marianna Aprile, Alfredo Ciccodicola
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 2021 (2022)
The growing incidence of diabetes mellitus worldwide implies the increasing prevalence of several related macro- (e.g., hypertension and atherosclerosis) and micro-vascular (e.g., nephropathy and retinopathy) complications. Notably, diabetic retinopa
Externí odkaz:
https://doaj.org/article/e468895c82c6489fb10116f872c4b717
Autor:
Gianluca Fasciolo, Gaetana Napolitano, Marianna Aprile, Simona Cataldi, Valerio Costa, Alfredo Ciccodicola, Sergio Di Meo, Paola Venditti
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1295 (2022)
Thyroid hormones are normally involved in glycaemic control, but their excess can lead to altered glucose metabolism and insulin resistance (IR). Since hyperthyroidism-linked increase in ROS results in tissue oxidative stress that is considered a hal
Externí odkaz:
https://doaj.org/article/a7feb5ef84624d2aacb5f1bead8d29c7
Autor:
Annacarmen Petrizzo, Maria Tagliamonte, Angela Mauriello, Valerio Costa, Marianna Aprile, Roberta Esposito, Andrea Caporale, Antonio Luciano, Claudio Arra, Maria Lina Tornesello, Franco M. Buonaguro, Luigi Buonaguro
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-14 (2018)
Abstract Background A novel prediction algorithm is needed for the identification of effective tumor associated mutated neoantigens. Only those with no homology to self wild type antigens are true predicted neoantigens (TPNAs) and can elicit an antit
Externí odkaz:
https://doaj.org/article/d5291a39983446b7bd9e9611b8b05f34
Autor:
Simona Cataldi, Marianna Aprile, Daniela Melillo, Inès Mucel, Sophie Giorgetti-Peraldi, Mireille Cormont, Paola Italiani, Matthias Blüher, Jean-François Tanti, Alfredo Ciccodicola, Valerio Costa
Publikováno v:
Cells, Vol 11, Iss 1, p 42 (2021)
Low-grade chronic inflammation and reduced differentiation capacity are hallmarks of hypertrophic adipose tissue (AT) and key contributors of insulin resistance. We identified PPARGΔ5 as a dominant-negative splicing isoform overexpressed in the AT o
Externí odkaz:
https://doaj.org/article/d5e0a62dcf1a4c379ece0afb622707a1
Autor:
Marianna Aprile, Simona Cataldi, Caterina Perfetto, Maria Rosaria Ambrosio, Paola Italiani, Rosarita Tatè, Matthias Blüher, Alfredo Ciccodicola, Valerio Costa
Publikováno v:
Cells, Vol 9, Iss 5, p 1284 (2020)
Reduced neo-adipogenesis and dysfunctional lipid-overloaded adipocytes are hallmarks of hypertrophic obesity linked to insulin resistance. Identifying molecular features of hypertrophic adipocytes requires appropriate in vitro models. We describe the
Externí odkaz:
https://doaj.org/article/8e172c12afe44027aca3d046825f0d20
Autor:
Marianna Aprile, Simona Cataldi, Maria Rosaria Ambrosio, Vittoria D’Esposito, Koini Lim, Arne Dietrich, Matthias Blüher, David Bousfield Savage, Pietro Formisano, Alfredo Ciccodicola, Valerio Costa
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1577-1592.e6 (2018)
Summary: Peroxisome-proliferator-activated receptor γ (PPARγ) regulates glucose and lipid homeostasis, insulin signaling, and adipocyte differentiation. Here, we report the skipping of exon 5 as a legitimate splicing event generating PPARγΔ5, a p
Externí odkaz:
https://doaj.org/article/02e891669fc44191935cad2f537773c1
Autor:
Luciana D’Apice, Valerio Costa, Rossella Sartorius, Maria Trovato, Marianna Aprile, Piergiuseppe De Berardinis
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
The filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adap
Externí odkaz:
https://doaj.org/article/3f288813b6de4957a73e8a8f04ca5c9b
Autor:
Valerio Costa, Claudia Angelini, Luciana D'Apice, Margherita Mutarelli, Amelia Casamassimi, Linda Sommese, Maria Assunta Gallo, Marianna Aprile, Roberta Esposito, Luigi Leone, Aldo Donizetti, Stefania Crispi, Monica Rienzo, Berardo Sarubbi, Raffaele Calabrò, Marco Picardi, Paola Salvatore, Teresa Infante, Piergiuseppe De Berardinis, Claudio Napoli, Alfredo Ciccodicola
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18493 (2011)
Hybridization- and tag-based technologies have been successfully used in Down syndrome to identify genes involved in various aspects of the pathogenesis. However, these technologies suffer from several limits and drawbacks and, to date, information a
Externí odkaz:
https://doaj.org/article/e2883b5932bf4b86bfd7a945914c2955