Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Marianna, Aprile"'
Autor:
Simona Cataldi, Marianna Aprile, Caterina Perfetto, Brice Angot, Mireille Cormont, Alfredo Ciccodicola, Jean-Francois Tanti, Valerio Costa
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151320- (2023)
Adipose tissue (AT) dysfunctions are associated with the onset of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Targeting glucose-dependent insulinotropic peptide receptor (GIPR) is a valid option to increase the efficacy of glucagon-l
Externí odkaz:
https://doaj.org/article/c2426c617b154c4cbf0f265f2bf32536
Autor:
Gianluca Fasciolo, Gaetana Napolitano, Marianna Aprile, Simona Cataldi, Valerio Costa, Maria Teresa Muscari Tomajoli, Assunta Lombardi, Sergio Di Meo, Paola Venditti
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 592 (2023)
While a low level of ROS plays a role in cellular regulatory processes, a high level can lead to oxidative stress and cellular dysfunction. Insulin resistance (IR) is one of the dysfunctions in which oxidative stress occurs and, until now, the factor
Externí odkaz:
https://doaj.org/article/989d8fc3e61c49268f391408a25aba2b
Autor:
Simona Cataldi, Mariagiovanna Tramontano, Valerio Costa, Marianna Aprile, Alfredo Ciccodicola
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 2021 (2022)
The growing incidence of diabetes mellitus worldwide implies the increasing prevalence of several related macro- (e.g., hypertension and atherosclerosis) and micro-vascular (e.g., nephropathy and retinopathy) complications. Notably, diabetic retinopa
Externí odkaz:
https://doaj.org/article/e468895c82c6489fb10116f872c4b717
Autor:
Gianluca Fasciolo, Gaetana Napolitano, Marianna Aprile, Simona Cataldi, Valerio Costa, Alfredo Ciccodicola, Sergio Di Meo, Paola Venditti
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1295 (2022)
Thyroid hormones are normally involved in glycaemic control, but their excess can lead to altered glucose metabolism and insulin resistance (IR). Since hyperthyroidism-linked increase in ROS results in tissue oxidative stress that is considered a hal
Externí odkaz:
https://doaj.org/article/a7feb5ef84624d2aacb5f1bead8d29c7
Autor:
Annacarmen Petrizzo, Maria Tagliamonte, Angela Mauriello, Valerio Costa, Marianna Aprile, Roberta Esposito, Andrea Caporale, Antonio Luciano, Claudio Arra, Maria Lina Tornesello, Franco M. Buonaguro, Luigi Buonaguro
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-14 (2018)
Abstract Background A novel prediction algorithm is needed for the identification of effective tumor associated mutated neoantigens. Only those with no homology to self wild type antigens are true predicted neoantigens (TPNAs) and can elicit an antit
Externí odkaz:
https://doaj.org/article/d5291a39983446b7bd9e9611b8b05f34
Autor:
Simona Cataldi, Marianna Aprile, Daniela Melillo, Inès Mucel, Sophie Giorgetti-Peraldi, Mireille Cormont, Paola Italiani, Matthias Blüher, Jean-François Tanti, Alfredo Ciccodicola, Valerio Costa
Publikováno v:
Cells, Vol 11, Iss 1, p 42 (2021)
Low-grade chronic inflammation and reduced differentiation capacity are hallmarks of hypertrophic adipose tissue (AT) and key contributors of insulin resistance. We identified PPARGΔ5 as a dominant-negative splicing isoform overexpressed in the AT o
Externí odkaz:
https://doaj.org/article/d5e0a62dcf1a4c379ece0afb622707a1
Publikováno v:
International Journal of Cancer. 152:822-834
The view of long noncoding RNAs as nonfunctional "garbage" has been definitely outdated by the large body of evidence indicating this class of ncRNAs as "golden junk", especially in precision oncology. Indeed, in light of their oncogenic role and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf3ede6463656a0c5fa2057b94e07d6
https://doi.org/10.1002/ijc.34282
https://doi.org/10.1002/ijc.34282
Autor:
Marianna Aprile, Simona Cataldi, Caterina Perfetto, Antonio Federico, Alfredo Ciccodicola, Valerio Costa
Publikováno v:
British Journal of Cancer.
Background B-raf inhibitors (BRAFi) are effective for BRAF-mutated papillary (PTC) and anaplastic (ATC) thyroid carcinomas, although acquired resistance impairs tumour cells’ sensitivity and/or limits drug efficacy. Targeting metabolic vulnerabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92a0171d3b5308e71eacccefcc8c1867
https://doi.org/10.1038/s41416-023-02282-2
https://doi.org/10.1038/s41416-023-02282-2
Publikováno v:
Epigenetic Cancer Therapy ISBN: 9780323913676
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ea8013c71db3faf557dcccbd3d6015f
https://doi.org/10.1016/b978-0-323-91367-6.00014-3
https://doi.org/10.1016/b978-0-323-91367-6.00014-3
Autor:
Marianna Aprile, Simona Cataldi, Caterina Perfetto, Maria Rosaria Ambrosio, Paola Italiani, Rosarita Tatè, Matthias Blüher, Alfredo Ciccodicola, Valerio Costa
Publikováno v:
Cells, Vol 9, Iss 5, p 1284 (2020)
Reduced neo-adipogenesis and dysfunctional lipid-overloaded adipocytes are hallmarks of hypertrophic obesity linked to insulin resistance. Identifying molecular features of hypertrophic adipocytes requires appropriate in vitro models. We describe the
Externí odkaz:
https://doaj.org/article/8e172c12afe44027aca3d046825f0d20