Detection of BRAF mutations in malignant melanoma and colorectal cancer by SensiScreen® FFPE BRAF qPCR assay.

Autor: Anna Lahn Sørensen, Mariann Guldmann-Christensen, Michael Børgesen, Rasmus Koefoed Petersen, Katharina Flugt, Julie Mejer Holmgaard Duelund, Majbritt Hauge Kyneb, Jan Lorenzen, Emma Pipó-Ollé, Samantha Epistolio, Alice Riva, Giulia Dazio, Elisabetta Merlo, Tine Meyer, Ulf Bech Christensen, Milo Frattini

Publikováno v: PLoS ONE, Vol 18, Iss 2, p e0281558 (2023)

Mutations in BRAF exon 15 lead to conformational changes in its activation loops, resulting in constitutively active BRAF proteins which are implicated in the development of several human cancer types. Different BRAF inhibitors have been developed an

Externí odkaz: https://doaj.org/article/7cb94f08d188463da9f8902651c45deb

SensiScreen®KRAS exon 2-sensitive simplex and multiplex real-time PCR-based assays for detection of KRAS exon 2 mutations

Autor: Jan Lorenzen, Elisabetta Merlo, Alice Riva, Milo Frattini, Stephen Hamilton-Dutoit, Michael Børgesen, Ulf Bech Christensen, Kirsten Voogd, Tine Yding Wolff, Samantha Epistolio, Majbritt Hauge Kyneb, Mariann Guldmann-Christensen, Christina Maar Andersen

Publikováno v: PLoS ONE
Riva, A, BØrgesen, M, Guldmann-Christensen, M, Hauge Kyneb, M, Voogd, K, Andersen, C, Epistolio, S, Merlo, E, Yding Wolff, T, Hamilton-Dutoit, S, Lorenzen, J, Christensen, U B & Frattini, M 2017, ' SensiScreen®KRAS exon 2-sensitive simplex and multiplex real-time PCR-based assays for detection of KRAS exon 2 mutations ', P L o S One, vol. 12, no. 6, pp. e0178027 . https://doi.org/10.1371/journal.pone.0178027
PLoS ONE, Vol 12, Iss 6, p e0178027 (2017)

Activating mutations in codon 12 and codon 13 of the KRAS (Kirsten rat sarcoma viral oncogene homolog) gene are implicated in the development of several human cancer types and influence their clinical evaluation, treatment and prognosis. Numerous dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37497aae91d3e94561d7dba325d42771
https://pubmed.ncbi.nlm.nih.gov/28636636

Novel, sensitive simplex and multiplex assays for KRAS and NRAS mutation detection

Autor: Christina Andersen, Cristiana Sessa, Michael Boergesen, Stephen Hamilton-Dutoit, Samantha Epistolio, Luca Mazzucchelli, Mariann Guldmann-Christensen, Jan Lorenzen, Majbritt Hauge Kyneb, Kirsten Voogd, Milo Frattini, Alice Riva, Ulf Bech Christensen, Tine Yde Wolff

Publikováno v: Journal of Clinical Oncology. 34:e23269-e23269

e23269Background: Activating KRAS/NRAS mutations in colorectal cancer (CRC) predict resistance to anti Epidermal Growth Factor Receptor targeted therapies. To improve the molecular characterization...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::329b621abafba20d08c8372f5f1b2f50
https://doi.org/10.1200/jco.2016.34.15_suppl.e23269