Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mariangela Siler"'
Autor:
Paola Infante, Roberta Faedda, Flavia Bernardi, Francesca Bufalieri, Ludovica Lospinoso Severini, Romina Alfonsi, Daniela Mazzà, Mariangela Siler, Sonia Coni, Agnese Po, Marialaura Petroni, Elisabetta Ferretti, Mattia Mori, Enrico De Smaele, Gianluca Canettieri, Carlo Capalbo, Marella Maroder, Isabella Screpanti, Marcel Kool, Stefan M. Pfister, Daniele Guardavaccaro, Alberto Gulino, Lucia Di Marcotullio
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
SuFu is a tumour suppressor in medulloblastoma and regulates Gli proteins in the Sonic Hedgehog pathway; however, the molecular mechanisms behind this regulation are unclear. Here, the authors show that the Itch/β-arrestin2 complex binds and ubiquit
Externí odkaz:
https://doaj.org/article/f7f69de80acf45bbb0fc69f6b60924c1
Autor:
Isabella Screpanti, Lucia Di Marcotullio, Marcel Kool, Paola Infante, Flavia Bernardi, Stefan M. Pfister, Mariangela Siler, Enrico De Smaele, Marialaura Petroni, Agnese Po, Alberto Gulino, Gianluca Canettieri, Romina Alfonsi, Mattia Mori, Marella Maroder, Sonia Coni, Francesca Bufalieri, Elisabetta Ferretti, Roberta Faedda, Carlo Capalbo, Daniele Guardavaccaro, Daniela Mazza, Ludovica Lospinoso Severini
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications, 9(1). Nature Publishing Group
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications, 9(1). Nature Publishing Group
Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6058d81e14b4dca94af95b9208e42e50
http://hdl.handle.net/11562/992664
http://hdl.handle.net/11562/992664
Autor:
Agnese Po, Danilo Cucchi, Gloria Uccello Barretta, Bruno Botta, Elisabetta Ferretti, Lucia Di Marcotullio, Maurizio Botta, Isabella Screpanti, Enrico De Smaele, Davide D'Amico, Mariangela Siler, Paola Infante, Sara Toscano, Mattia Mori, Romina Alfonsi, Francesca Ghirga, Cinzia Ingallina, Federica Aiello, Alberto Gulino, Gianluca Canettieri, Evelina Miele
Publikováno v:
ResearcherID
The EMBO Journal
The EMBO Journal
Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result of genetic mutations of pathway components or other Smo-dependent or i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228fdc4f8abcc715fc2bf366b664f9b8
http://hdl.handle.net/11568/760829
http://hdl.handle.net/11568/760829
Autor:
Romina Alfonsi, Valeria Colicchia, Mariangela Siler, Elisabetta Ferretti, Agnese Po, L Di Marcotullio, Paola Infante, Isabella Screpanti, Gianluca Canettieri, Diana Bellavia, E De Smaele, Carlo Capalbo, Daniela Mazza, Giuseppe Giannini, A Greco, Alberto Gulino, Laura Antonucci
The Hedgehog (Hh) signaling regulates tissue development, and its aberrant activation is a leading cause of malignancies, including medulloblastoma (Mb). Hh-dependent tumorigenesis often occurs in synergy with other mechanisms, such as loss of p53, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dc5a18bb02f25c564b0cdb7ee40b4f
http://hdl.handle.net/11573/527250
http://hdl.handle.net/11573/527250