The Immunomodulatory Properties of the Human Amnion-Derived Mesenchymal Stromal/Stem Cells Are Induced by INF-γ Produced by Activated Lymphomonocytes and Are Mediated by Cell-To-Cell Contact and Soluble Factors

Autor: Matteo Bulati, Vitale Miceli, Alessia Gallo, Giandomenico Amico, Claudia Carcione, Mariangela Pampalone, Pier Giulio Conaldi

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Human mesenchymal stromal/stem cells (MSCs), being immunoprivileged and having immunomodulatory ability, represent a promising tool to be applied in the field of regenerative medicine. Based on numerous in vitro evidences, the immunological effects o

Externí odkaz: https://doaj.org/article/0bdd84fd94a644e881c37b5bc4efdddf

Human Amnion-Derived Mesenchymal Stromal Cells in Cirrhotic Patients with Refractory Ascites: A Possible Anti-Inflammatory Therapy for Preventing Spontaneous Bacterial Peritonitis

Autor: Giandomenico Amico, Pier Giulio Conaldi, Giada Pietrosi, Giampiero Vitale, Simona Corrao, Mariangela Pampalone, Rossella Alduino

Publikováno v: Stem Cell Reviews and Reports

Graphical abstract Cirrhosis is associated with dysregulated immune cell activation and immune dysfunction. These conditions modify gut flora, facilitate bacterial translocation, and increase susceptibility to bacterial peritonitis and consequent sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cc17928c500a1e46c5a060a9dde841
https://doi.org/10.1007/s12015-020-10104-8

Changes in the Transcriptome Profiles of Human Amnion-Derived Mesenchymal Stromal/Stem Cells Induced by Three-Dimensional Culture: A Potential Priming Strategy to Improve Their Properties

Autor: Alessia Gallo, Nicola Cuscino, Flavia Contino, Matteo Bulati, Mariangela Pampalone, Giandomenico Amico, Giovanni Zito, Claudia Carcione, Claudio Centi, Alessandro Bertani, Pier Giulio Conaldi, Vitale Miceli

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 863, p 863 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 863

Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these cells are expanded in two-dimensional (2D) cultures, and, in that cas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72f027743d654c7625750d0706f4904
http://hdl.handle.net/10447/555566

Comparative study of the production of soluble factors in human placenta-derived mesenchymal stromal/stem cells grown in adherent conditions or as aggregates in a catheter-like device

Autor: Vitale Miceli, Pier Giulio Conaldi, Mariangela Pampalone, Cinzia Maria Chinnici, Eva Schmelzer, Jörg C. Gerlach, Giandomenico Amico, Matteo Bulati

Different approaches have been studied in both preclinical and clinical settings to develop cell-based therapies and/or engineered cell-based therapies to better integrate grafts with the host. In these techniques, much attention is addressed to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298b9c28c4b631ca533d61dd7a131793
http://hdl.handle.net/10447/555593

Placenta-derived mesenchymal stem cells enhance human liver organoid maturation: translational implications for liver regeneration

Autor: Vitale Miceli, Mariangela Pampalone, Pier Giulio Conaldi, A. Lo Nigro, Giampiero Vitale

Publikováno v: Cytotherapy. 22:S96-S97

Background & Aim The global prevalence of end-stage liver disease (ESLD) has reached very high levels, and, to date, the best treatment option is orthotopic liver transplantation (1). However, due to the complexity of this procedure and the limited n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44f559689da22e9537643a6b8831b99c
https://doi.org/10.1016/j.jcyt.2020.03.167