Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marianela Nelson"'
Autor:
Laura J. Mosher, Sean C. Godar, Marianela Nelson, Stephen C. Fowler, Graziano Pinna, Marco Bortolato
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple tics and sensorimotor abnormalities, the severity of which is typically increased by stress. The neurobiological underpinnings of this exacerbation, however, rem
Externí odkaz:
https://doaj.org/article/3ab4a6989ba3454dac75b5a92be0ee11
Autor:
Kamryn T. Eddy, Elizabeth A. Lawson, Ann M. Rasmusson, Karen K. Miller, Marianela Nelson, Graziano Pinna, Erinne Meenaghan, Melanie Schorr, Margaret Lederfine Paskal, Anne Klibanski, Laura E. Dichtel
3α-5α-Tetrahydroprogesterone, a progesterone metabolite also known as allopregnanolone, and 5α-androstane-3α,17β-diol, a testosterone metabolite also known as 3α-androstanediol, are neuroactive steroids and positive GABA(A) receptor allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8416ea745c973b95554d2960ae93b084
https://europepmc.org/articles/PMC5916351/
https://europepmc.org/articles/PMC5916351/
Autor:
John P. O'Bryan, Michael Kurzer, Elizabeth Head, Michael P. Hunter, Richard J. Kryscio, Marianela Nelson, Graziano Pinna, Xuerong Wang
Publikováno v:
NeuroReport. 22:767-772
Intersectin 1 (ITSN1) is a human chromosome 21 (HSA21) gene product encoding a multidomain scaffold protein that functions in endocytosis, signal transduction, and is implicated in Down's syndrome, Alzheimer's Disease, and potentially other neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719fca075bfa4b9651e13d48081a32a5
https://doi.org/10.1097/wnr.0b013e32834ae348
https://doi.org/10.1097/wnr.0b013e32834ae348
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13614-13619
Cortical GABAergic dysfunction, a hallmark of both schizophrenia (SZ) and bipolar (BP) disorder pathophysiologies may relate to the hypermethylation of GABAergic gene promoters (i.e., reelin and GAD67). Benefits elicited by a combination of atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbe6afa37bcc3e2941a49af90a29bf9
https://doi.org/10.1073/pnas.0805493105
https://doi.org/10.1073/pnas.0805493105
Autor:
Roberto Carlos Agis-Balboa, Erminio Costa, Fabio Pibiri, Marianela Nelson, Alessandro Guidotti, Graziano Pinna
Publikováno v:
Neurochemical Research. 33:1990-2007
The neurosteroid allopregnanolone is a potent positive allosteric modulator of GABA action at GABA(A) receptors. Allopregnanolone is synthesized in the brain from progesterone by the sequential action of 5alpha-reductase type I (5alpha-RI) and 3alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc922c35bd559bc3455ec3b8ef8f3022
https://doi.org/10.1007/s11064-008-9718-5
https://doi.org/10.1007/s11064-008-9718-5
Publikováno v:
Proceedings of the National Academy of Sciences. 105:5567-5572
Mice subjected to social isolation (3–4 weeks) exhibit enhanced contextual fear responses and impaired fear extinction. These responses are time-related to a decrease of 5α-reductase type I (5α-RI) mRNA expression and allopregnanolone (Allo) leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe8fe2a90d675fbe19ff1525ce8e7ed
https://doi.org/10.1073/pnas.0801853105
https://doi.org/10.1073/pnas.0801853105
Publikováno v:
NeuroReport. 17:1537-1541
Anabolic androgenic steroid abuse triggers impulsive aggression, anxiety, and depression, which suggests a dysfunction of GABAergic neurotransmission. Socially isolated female mice that have received testosterone propionate (1.45 micromol/kg) treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c15482be34025faf614ff621eddc90
https://doi.org/10.1097/01.wnr.0000234752.03808.b2
https://doi.org/10.1097/01.wnr.0000234752.03808.b2
Autor:
Marianela Nelson, Graziano Pinna
Publikováno v:
Neuropharmacology. 60(7-8)
A decrease of brain allopregnanolone biosynthesis may play a role in emotion, impulsive behavior, and anxiety spectrum disorders by decreasing GABAergic neurotransmission. In male mice, four weeks of social isolation induces behavioral dysfunctions s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08db8d9be00d4a27717b968a178dc738
https://pubmed.ncbi.nlm.nih.gov/20971127
https://pubmed.ncbi.nlm.nih.gov/20971127
Corticolimbic neurons express neurosteroid biosynthesis, which is altered during anabolic androgenic steroid (AAS) treatment. The brain circuits and neurons that underlie the behavioral deficits found after AAS treatment remain undefined. We studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa84250591207c3cdc90a6a9dd6ddbf
https://europepmc.org/articles/PMC3100179/
https://europepmc.org/articles/PMC3100179/
Autor:
James Auta, Javaid I. Javaid, Marianela Nelson, David H. Overstreet, D Lecca, Alessandro Guidotti, Erminio Costa
Publikováno v:
Neuropharmacology. 39(13)
Rats of Flinders Sensitive (FSL) and Flinders Resistant lines (FRL) differ in their susceptibility to physiological and associated behavioral responses elicited by nicotine. In the present study, we measured dopamine (DA) content in striatal dialysat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13939856628ebc4660cbfcc86de6eb5
https://pubmed.ncbi.nlm.nih.gov/11044732
https://pubmed.ncbi.nlm.nih.gov/11044732