Biguanides enhance antifungal activity against Candida glabrata

Autor: Shuying Xu, Marianela Feliu, Allison K. Lord, Daniel P. Lukason, Paige E. Negoro, Nida S. Khan, Zeina Dagher, Michael B. Feldman, Jennifer L. Reedy, Samantha N. Steiger, Jenny M. Tam, Alexander A. Soukas, David B. Sykes, Michael K. Mansour

Publikováno v: Virulence, Vol 9, Iss 1, Pp 1150-1162 (2018)

Candida spp. are the fourth leading cause of nosocomial blood stream infections in North America. Candida glabrata is the second most frequently isolated species, and rapid development of antifungal resistance has made treatment a challenge. In this

Externí odkaz: https://doaj.org/article/aaf0263e893d4e9ab7b1c1e88e54c095

CD82 controls CpG‐dependent TLR9 signaling

Autor: Pia V. Kasperkovitz, Eva-Maria Frickel, Allison K. Lord, Stuart M. Levitz, Nida S. Khan, Paige E. Negoro, Daniel P Lukason, Zeina Dagher, Christine Becker, Mridu Acharaya, Cindy K. Miranti, Katerina Artavanis-Tsakonas, Jennifer L. Reedy, You-Me Kim, Jenny M. Tam, Hidde L. Ploegh, Jatin M. Vyas, Eicke Latz, Zaida G. Ramirez-Ortiz, Tammy Vyas, Rebecca A Ward, Marianela Feliu, Shuying Xu, Michael K. Mansour, Melanie M. Brinkmann

Publikováno v: The FASEB journal 33(11), 12500-12514 (2019). doi:10.1096/fj.201901547R

The tetraspanin CD82 is a potent suppressor of tumor metastasis and regulates several processes including signal transduction, cell adhesion, motility, and aggregation. However, the mechanisms by which CD82 participates in innate immunity are unknown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fff8102b319cdbe55e5fc0cb17c5ab0
https://doi.org/10.1096/fj.201901547r

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

Autor: Kara L. Conway, Caroline Stefani, Adam Lacy-Hulbert, Subhankar Mukhopadhyay, Anna Sokolovska, Ramnik J. Xavier, Fiona Raso, Richard O. Hynes, Jenny M. Tam, John Savill, Marianela Feliu, Lynda M. Stuart, Jatin M. Vyas, Mridu Acharya, Elahna Paul

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Nature
Nature Communications
Acharya, M, Sokolovska, A, Tam, J M, Conway, K L, Stefani, C, Raso, F, Mukhopadhyay, S, Feliu, M, Paul, E, Savill, J, Hynes, R O, Xavier, R J, Vyas, J M, Stuart, L M & Lacy-Hulbert, A 2016, ' αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells ', Nature Communications, vol. 7, 10917 . https://doi.org/10.1038/ncomms10917

Integrin signalling triggers cytoskeletal rearrangements, including endocytosis and exocytosis of integrins and other membrane proteins. In addition to recycling integrins, this trafficking can also regulate intracellular signalling pathways. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03911436e8a5999df981aac2881fbaf9
https://doaj.org/article/dc8efeea8b80409f8e4a56aef9dd4da0

The Carbohydrate Lectin Receptor Dectin-1 Mediates the Immune Response to Exserohilum rostratum

Autor: Thomas F. Patterson, Jatin M. Vyas, Nathan P. Wiederhold, Dan P. Lukason, Michael K. Mansour, Marianela Feliu, Allison K. Lord, Jennifer L. Reedy, Jenny M. Tam, Paige E. Negoro, Nida S. Khan

Publikováno v: Infection and Immunity. 85

Dematiaceous molds are found ubiquitously in the environment and cause a wide spectrum of human disease, including infections associated with high rates of mortality. Despite this, the mechanism of the innate immune response has been less well studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ab0b39f77e20725a8d69ce6e9612fc
https://doi.org/10.1128/iai.00903-16

The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis

Autor: Anna E. Koh, Elahna Paul, Robert B. Colvin, Marianela Feliu, Alexis Cook, Martin K. Selig, Yvette Latchman, Sarah W. Njoroge, Arlene H. Sharpe

Publikováno v: Journal of Autoimmunity. 37:48-57

Polymorphisms in the SLAM family of leukocyte cell surface regulatory molecules have been associated with lupus-like phenotypes in both humans and mice. The murine Slamf gene cluster lies within the lupus-associated Sle1b region of mouse chromosome 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e84148e2bc5a871c44275b471d4cb04
https://doi.org/10.1016/j.jaut.2011.03.004