Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mariane, da Cunha Jaeger"'
Autor:
Matheus Loureiro da Silva Cruz, Rafael Pereira dos Santos, Barbara Kunzler Souza, Mariane da Cunha Jaeger, Camila Alves da Silva, Lauro José Gregianin, Jiseh Fagundes Loss, Rebeca Ferreira Marques, Algemir Lunardi Brunetto, André Tesainer Brunetto, Rafael Roesler, Caroline Brunetto de Farias
Publikováno v:
Revista Brasileira de Cancerologia, Vol 69, Iss 3 (2023)
Introduction: Acute lymphocytic leukemia (ALL) is the most common cancer type in children and accounts for 80% of pediatric leukemias. Novel targets are necessary to improve survival rates for refractory and relapsed disease. There is accumulating ev
Externí odkaz:
https://doaj.org/article/09ba00fd63214fcdbaea678fe9b6ef79
Autor:
Rafael Pereira, Dos Santos, Lauro, Gregianin, André, T Brunetto, Mariane, da Cunha Jaeger, Algemir, Lunardi Brunetto, Caroline, Brunetto de Farias, Rafael, Roesler
Publikováno v:
Current Stem Cell Research & Therapy. 18:926-936
Abstract: Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can lead cancer cells to acquire a stem-cell phenotype characterized by expression of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18146f761033315795837b37df1ea710
https://doi.org/10.2174/1574888x17666220627114710
https://doi.org/10.2174/1574888x17666220627114710
Autor:
Clévia Rosset, Mariane da Cunha Jaeger, Eduardo Filippi-Chiela, Larissa Brussa Reis, Ivaine Taís Sauthier Sartor, Cristina Brinckmann Oliveira Netto, Caroline Brunetto de Farias, Rafael Roesler, Patricia Ashton-Prolla
Publikováno v:
Genetics and Molecular Biology, Vol 44, Iss 4 (2021)
Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of heterozy
Externí odkaz:
https://doaj.org/article/fe7d672f066a416495abc777371618de
Autor:
Sara Badodi, Adrian Dubuc, Xinyu Zhang, Gabriel Rosser, Mariane Da Cunha Jaeger, Michelle M. Kameda-Smith, Anca Sorana Morrissy, Paul Guilhamon, Philipp Suetterlin, Xiao-Nan Li, Loredana Guglielmi, Ashirwad Merve, Hamza Farooq, Mathieu Lupien, Sheila K. Singh, M. Albert Basson, Michael D. Taylor, Silvia Marino
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2772-2784 (2017)
Summary: We describe molecular convergence between BMI1 and CHD7 in the initiation of medulloblastoma. Identified in a functional genomic screen in mouse models, a BMI1High;CHD7Low expression signature within medulloblastoma characterizes patients wi
Externí odkaz:
https://doaj.org/article/60f4f3d022f54adf9316a3789fd48058
Autor:
Amanda Thomaz, Kelly de Vargas Pinheiro, Bárbara Kunzler Souza, Lauro Gregianin, Algemir L. Brunetto, André T. Brunetto, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Vijay Ramaswamy, Carolina Nör, Michael D. Taylor, Rafael Roesler
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated
Externí odkaz:
https://doaj.org/article/b5b0e0b16162448d9954f355f8f89f01
Autor:
Natália Hogetop Freire, Mariane da Cunha Jaeger, Caroline Brunetto de Farias, Carolina Nör, Barbara Kunzler Souza, Lauro Gregianin, André Tesainer Brunetto, Rafael Roesler
Publikováno v:
Molecular and Cellular Biochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45d7b476e8a0357e466e6e36fb5265f5
https://doi.org/10.1007/s11010-022-04655-2
https://doi.org/10.1007/s11010-022-04655-2
Autor:
Lisa Shaw, Lívia Fratini, Mariane da Cunha Jaeger, André T Brunetto, Rafael Roesler, Algemir Lunardi Brunetto, Caroline Brunetto de Farias
Publikováno v:
Molecular and Cellular Biochemistry. 476:4107-4116
The transcription factor Zinc finger E-box binding 1 (ZEB1) displays a range of regulatory activities in cell function and embryonic development, including driving epithelial-mesenchymal transition. Several aspects of ZEB1 function can be regulated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b8ad998337f53dc533e07dfc42c587
https://doi.org/10.1007/s11010-021-04226-x
https://doi.org/10.1007/s11010-021-04226-x
Autor:
Livia Fratini, Matheus Gibeke Siqueira Dalmolin, Marialva Sinigaglia, Alexandre da Silveira Perla, Caroline Brunetto de Farias, Algemir L. Brunetto, André T. Brunetto, Mariane da Cunha Jaeger, Rafael Roesler
Publikováno v:
Neuromolecular medicine.
Medulloblastoma (MB) is a malignant brain tumor that afflicts mostly children and adolescents and presents four distinct molecular subgroups, known as WNT, SHH, Group 3, and Group 4. ZEB1 is a transcription factor that promotes the expression of mese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932a77f5c4c5a6df7dad53d576f145ba
https://pubmed.ncbi.nlm.nih.gov/35716340
https://pubmed.ncbi.nlm.nih.gov/35716340
Autor:
Alexandre da Silveira Perla, Paula Schoproni Cardoso, Mariane da Cunha Jaeger, Lívia Fratini, Caroline Brunetto de Farias, Rafael Roesler
Publikováno v:
Pediatric Hematology and Oncology. 37:170-175
Histone deacetylase inhibitors (HDACis) are epigenetic agents that display antitumor activities in experimental medulloblastoma (MB). Fingolimod (FTY720), an immunosuppressant agent currently used in the treatment of multiple sclerosis, also has anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b111e802d2cc6224684d53bed97f34
https://doi.org/10.1080/08880018.2019.1699213
https://doi.org/10.1080/08880018.2019.1699213
Autor:
Kelly de Vargas Pinheiro, André T Brunetto, Marienela Buendia Duque, Amanda Thomaz, Rafael Roesler, Caroline Brunetto de Farias, Camila Alves da Silva, Gilberto Schwartsmann, Natalia Hogetop Freire, Mariane da Cunha Jaeger
Publikováno v:
Journal of Molecular Neuroscience. 68:49-57
Changes in expression of histone deacetylases (HDACs), which epigenetically regulate chromatin structure, and mutations and amplifications of the EGFR gene, which codes for the epidermal growth factor receptor (EGFR), have been reported in glioblasto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f5f326349c708596ae360cb709589c
https://doi.org/10.1007/s12031-019-01280-5
https://doi.org/10.1007/s12031-019-01280-5