Výsledky vyhledávání - "Mariana Vinacur"

Akademický článek

A comprehensive synthetic library of poly-N-acetyl glucosamines enabled vaccine against lethal challenges of Staphylococcus aureus

Autor: Zibin Tan, Weizhun Yang, Nicholas A. O’Brien, Xingling Pan, Sherif Ramadan, Terence Marsh, Neal Hammer, Colette Cywes-Bentley, Mariana Vinacur, Gerald B. Pier, Jeffrey C. Gildersleeve, Xuefei Huang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Poly-β-(1–6)-N-acetylglucosamine (PNAG) is an important vaccine target, expressed on many pathogens. A critical hurdle in developing PNAG based vaccine is that the impacts of the number and the position of free amine vs N-acetylation on i

Externí odkaz: https://doaj.org/article/3bb1198e173a4bd293f55ac76b647033

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Akademický článek

Randomized, controlled trial comparing Rhodococcus equi and poly‐N‐acetyl glucosamine hyperimmune plasma to prevent R equi pneumonia in foals

Autor: Susanne K. Kahn, Colette Cywes‐Bentley, Glenn P. Blodgett, Nathan M. Canaday, Carly E. Turner‐Garcia, Patricia Flores‐Ahlschwede, Laurie L. Metcalfe, Mark Nevill, Mariana Vinacur, Patrick J. Sutter, Sarah C. Meyer, Angela I. Bordin, Gerald B. Pier, Noah D. Cohen

Publikováno v: Journal of Veterinary Internal Medicine, Vol 35, Iss 6, Pp 2912-2919 (2021)

Abstract Background Hyperimmune plasma raised against β‐1→6‐poly‐N‐acetyl glucosamine (PNAG HIP) mediates more opsonophagocytic killing of Rhodococcus equi (R equi) than does R equi hyperimmune plasma (RE HIP) in vitro. The relative effica

Externí odkaz: https://doaj.org/article/b8a0a336180c4bb5b0edefd34d91526c

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Akademický článek

Serum Antibody Activity against Poly-N-Acetyl Glucosamine (PNAG), but Not PNAG Vaccination Status, Is Associated with Protecting Newborn Foals against Intrabronchial Infection with Rhodococcus equi

Autor: Noah D. Cohen, Susanne K. Kahn, Colette Cywes-Bentley, Sophia Ramirez-Cortez, Amanda E. Schuckert, Mariana Vinacur, Angela I. Bordin, Gerald B. Pier

Publikováno v: Microbiology Spectrum, Vol 9, Iss 1 (2021)

ABSTRACT Rhodococcus equi is a prevalent cause of pneumonia in foals worldwide. Our laboratory has demonstrated that vaccination against the surface polysaccharide β-1→6-poly-N-acetylglucosamine (PNAG) protects foals against intrabronchial infecti

Externí odkaz: https://doaj.org/article/24151ab2c0c54e9aa0962aadf2c8117f

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Akademický článek

Antibody activities in hyperimmune plasma against the Rhodococcus equi virulence -associated protein A or poly-N-acetyl glucosamine are associated with protection of foals against rhodococcal pneumonia.

Autor: Susanne K Kahn, Colette Cywes-Bentley, Glenn P Blodgett, Nathan M Canaday, Carly E Turner-Garcia, Mariana Vinacur, Sophia C Cortez-Ramirez, Patrick J Sutter, Sarah C Meyer, Angela I Bordin, Daniel R Vlock, Gerald B Pier, Noah D Cohen

Publikováno v: PLoS ONE, Vol 16, Iss 8, p e0250133 (2021)

The efficacy of transfusion with hyperimmune plasma (HIP) for preventing pneumonia caused by Rhodococcus equi remains ill-defined. Quarter Horse foals at 2 large breeding farms were randomly assigned to be transfused with 2 L of HIP from adult donors

Externí odkaz: https://doaj.org/article/5c9f5f033fbe46f0bf40e651dc78a441

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Akademický článek

Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi.

Autor: Colette Cywes-Bentley, Joana N Rocha, Angela I Bordin, Mariana Vinacur, Safia Rehman, Tanweer S Zaidi, Mark Meyer, Sarah Anthony, McKenzie Lambert, Daniel R Vlock, Steeve Giguère, Noah D Cohen, Gerald B Pier

Publikováno v: PLoS Pathogens, Vol 14, Iss 7, p e1007160 (2018)

Immune correlates of protection against intracellular bacterial pathogens are largely thought to be cell-mediated, although a reasonable amount of data supports a role for antibody-mediated protection. To define a role for antibody-mediated immunity

Externí odkaz: https://doaj.org/article/ac3f2677431c4a639283cac00dfe5a32

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Randomized, controlled trial comparing Rhodococcus equi and poly‐ N ‐acetyl glucosamine hyperimmune plasma to prevent R equi pneumonia in foals

Autor: Sarah Meyer, Glenn P. Blodgett, Patrick J Sutter, Gerald B. Pier, Colette Cywes-Bentley, Mariana Vinacur, Carly E Turner-Garcia, Nathan M Canaday, Patricia Flores-Ahlschwede, Laurie L Metcalfe, Susanne K Kahn, Mark Nevill, Angela I. Bordin, Noah D. Cohen

Publikováno v: Journal of Veterinary Internal Medicine. 35:2912-2919

Background Hyperimmune plasma raised against β-1→6-poly-N-acetyl glucosamine (PNAG HIP) mediates more opsonophagocytic killing of Rhodococcus equi (R equi) than does R equi hyperimmune plasma (RE HIP) in vitro. The relative efficacy of PNAG HIP an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41b7ab2cb8aec61d2d85efc755e594dc
https://doi.org/10.1111/jvim.16294

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9 Higher antibody concentrations in hyperimmune plasma against the virulence protein A and poly-N-acetyl glucosamine provide greater protection against rhodococcal foal pneumonia

Autor: Mariana Vinacur, Noah D. Cohen, Glenn P. Blodgett, Nathan M Canaday, Colette Cywes-Bentley, C. Turner Garcia, Patrick J Sutter, Susanne K Kahn, Gerald B. Pier, Sarah Meyer, Daniel R. Vlock, Angela I. Bordin

Publikováno v: Journal of Equine Veterinary Science. 100:103472

Pneumonia caused by the bacterium Rhodococcus equi (RE) is an important cause of disease and death in foals at breeding farms worldwide. The efficacy of transfusion with hyperimmune plasma (HIP) for preventing RE pneumonia remains ill-defined. The ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b8e84b246ffe4de69b2113657fb5912
https://doi.org/10.1016/j.jevs.2021.103472

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Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi

Autor: McKenzie Lambert, Daniel R. Vlock, Angela I. Bordin, Joana N. Rocha, Sarah Anthony, Mark Meyer, Safia Rehman, Gerald B. Pier, Noah D. Cohen, Tanweer Zaidi, Mariana Vinacur, Colette Cywes-Bentley, Steeve Giguère

Publikováno v: PLoS Pathogens, Vol 14, Iss 7, p e1007160 (2018)
PLoS Pathogens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115c3367c6fa72c9d94af9e4f28ed479
http://europepmc.org/articles/PMC6053243?pdf=render

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