SHOC2 scaffold protein modulates daunorubicin-induced cell death through p53 modulation in lymphoid leukemia cells

Autor: Vanessa Silva Silveira, Kleiton Silva Borges, Verena Silva Santos, Mariana Tannús Ruckert, Gabriela Maciel Vieira, Elton José Rosas Vasconcelos, Luis Fernando Peinado Nagano, Luiz Gonzaga Tone, Carlos Alberto Scrideli

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)

Abstract SHOC2 scaffold protein has been mainly related to oncogenic ERK signaling through the RAS-SHOC2-PP1 phosphatase complex. In leukemic cells however, SHOC2 upregulation has been previously related to an increased 5-year event-free survival of

Externí odkaz: https://doaj.org/article/70109987fc1b425ba3936d97783b5127

The role of dual-specificity phosphatase 6 (DUSP6) in metastasis and metabolism of pancreatic cancer cells

Autor: Mariana Tannús Ruckert

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor and is majorly caused by the constitutive activation of mutant KRAS - found in more than 90% of PDAC cases. The undruggability of KRAS mutations has led to efforts of finding new th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4d908e4eeb49ff8af47fa18412c5a6
https://doi.org/10.11606/t.17.2022.tde-09112022-122218

HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate

Autor: Jan Jacob Schuringa, Annet Z. Brouwers-Vos, Luis Fernando Peinado Nagano, Vanessa da Silva Silveira, Mariana Tannús Ruckert

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cancer Gene Therapy, 830-833. Nature Publishing Group
ISSUE=10-11;STARTPAGE=830;ENDPAGE=833;ISSN=0929-1903;TITLE=Cancer Gene Therapy

Acute myeloid leukemia (AML) is a poor prognosis hematopoietic malignance characterized by abnormal proliferation and differentiation of hematopoietic stem cells (HSCs). Although advances in treatment have greatly improved survival rates in young pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1513327e7ebb96706a6d5dc4719267
https://doi.org/10.1038/s41417-020-0198-3

Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma

Autor: Mariana Tannús Ruckert, Vanessa da Silva Silveira, Verena Silva Santos, Pamela Viani de Andrade

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It is the fourth leading cause of cancer-related death and is associated with a very poor prognosis. KRAS driver mutations occur in approximately 95% of PDAC cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e146a1de0c7c5fe4c426d5dfffb00d44

Abstract C51: Targeted inhibition of DUSP1 and DUSP6 suppresses pancreatic adenocarcinoma cells’ growth and glucose metabolism via SAPK/JNK pathway activation

Autor: Mariana Tannús Ruckert, Pamela Viani de Andrade, Vanessa da Silva Silveira, Carlos Alberto O. Biagi Junior

Publikováno v: Cancer Research. 79:C51-C51

The highly malignant potential and aggressiveness of pancreatic adenocarcinoma cells is mainly promoted by oncogenic KRAS activation, which triggers numerous signaling pathways and controls key processes for tumor progression such as cell survival an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6b6884b275fdea9e05c95415a4f90e3
https://doi.org/10.1158/1538-7445.panca19-c51