Protein Delivery of Cell-Penetrating Zinc-Finger Activators Stimulates Latent HIV-1-Infected Cells

Autor: Pedro R.L. Perdigão, Catarina Cunha-Santos, Carlos F. Barbas, III, Mariana Santa-Marta, Joao Goncalves

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 145-158 (2020)

Despite efforts to develop effective treatments for eradicating HIV-1, a cure has not yet been achieved. Whereas antiretroviral drugs target an actively replicating virus, latent, nonreplicative forms persist during treatment. Pharmacological strateg

Externí odkaz: https://doaj.org/article/ad59ae7f6a2f4b18b663137ff8b65092

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

Autor: Pedro Perdigão, Thomas Gaj, Mariana Santa-Marta, Carlos F Barbas, Joao Goncalves

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0150037 (2016)

The presence of replication-competent HIV-1 -which resides mainly in resting CD4+ T cells--is a major hurdle to its eradication. While pharmacological approaches have been useful for inducing the expression of this latent population of virus, they ha

Externí odkaz: https://doaj.org/article/b9f0a52a4272401c8ef65aaf9995cef0

Can asymmetric post-translational modifications regulate the behavior of STAT3 homodimers?

Autor: Vanesa Martín, Joana Branco-Santos, Fernanda Murtinheira, Ana Maia Rocha, Carmen Rodríguez, Mariana Santa-Marta, Ricardo Letra-Vilela, Catarina Silva-Almeida, Beatriz Cardoso, Federico Herrera

Publikováno v: Scopus
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
FASEB BioAdvances, Vol 2, Iss 2, Pp 116-125 (2020)
FASEB bioAdvances

Signal transducer and activator of transcription 3 (STAT3) is a ubiquitous and pleiotropic transcription factor that plays essential roles in normal development, immunity, response to tissue damage and cancer. We have developed a Venus‐STAT3 bimole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e6d038604b97129ff882f742a5ad7a
http://hdl.handle.net/10651/59220

mi RNA profiling of human naive CD 4 T cells links miR‐34c‐5p to cell activation and HIV replication

Autor: João Gonçalves, Mariana Santa-Marta, Ana Serra-Caetano, Paula Matoso, Margarida Gama-Carvalho, Cheila Rocha, Christian G. Ramos, Rui S. Soares, José Afonso Guerra-Assunção, Russell B. Foxall, Ana M. Matos, Rita Tendeiro, Jorge Andrade, Ana E. Sousa, Andreia J. Amaral

Publikováno v: The EMBO Journal. 36:346-360

Cell activation is a vital step for T‐cell memory/effector differentiation as well as for productive HIV infection. To identify novel regulators of this process, we used next‐generation sequencing to profile changes in microRNA expression occurri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a595c5830c1d97a8e040fd8ccd02d12
https://doi.org/10.15252/embj.201694335

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors

Autor: Mariana Santa-Marta, João Gonçalves, Carlos F. Barbas, Thomas Gaj, Pedro Ricardo Lucas Perdigao

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0150037 (2016)

The presence of replication-competent HIV-1 -which resides mainly in resting CD4+ T cells--is a major hurdle to its eradication. While pharmacological approaches have been useful for inducing the expression of this latent population of virus, they ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9b563769667f58bf9832b76ced053f
http://europepmc.org/articles/PMC4774903