Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mariana S. Damian"'
Publikováno v:
Zeitschrift für anorganische und allgemeine Chemie. 639:1655-1660
Thermodynamic parameters are presented here illustrating the effects caused by the two anticancer active metal complexes cisplatin and oxaliplatin after introduction into four closely related RNA and DNA duplexes. The duplexes used are blunt end, ful
Publikováno v:
European Journal of Organic Chemistry. 2010:6161-6170
Modification and optimization of the anticancer drug cisplatin is of interest with respect to selective cell targeting and DNA binding efficiency. Attractive approaches contain both, modification of the platinum coordination sphere and design of hybr
Publikováno v:
Organicbiomolecular chemistry. 13(48)
Conjugation of metal complexes with peptide scaffolds possessing high DNA binding affinity has shown to modulate their biological activities and to enhance their interaction with DNA. In this work, a platinum complex/peptide chimera was synthesized b
Publikováno v:
European Journal of Organic Chemistry. 2010
The cover picture shows the covalent DNA binding of cisplatin-like complexes. These molecules were designed as hybrids between the platinum coordination site and positively charged peptides, which involves the covalent binding of one or two nucleobas