Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4(3H)-one: Synthesis and In Vitro Activities Evaluation

Autor: Raluca Pele, Gabriel Marc, Ioana Ionuț, Cristina Nastasă, Ionel Fizeșan, Adrian Pîrnău, Laurian Vlase, Mariana Palage, Smaranda Oniga, Ovidiu Oniga

Publikováno v: Pharmaceutics, Vol 15, Iss 1, p 136 (2022)

The development of hybrid molecules with significant human therapeutic properties is one of the main approaches of pharmaceutical research. One of the most important pharmacophores is the quinazolin-4(3H)-one heterocycle moiety, due to its wide range

Externí odkaz: https://doaj.org/article/ae25de6798294003950861cf13338914

Food and Gastroesophageal Reflux Disease

Autor: Mariana Palage, Dana E. Negrutiu, Teodora Surdea-Blaga, Dan L. Dumitrascu

Publikováno v: Current Medicinal Chemistry. 26:3497-3511

Gastroesophageal reflux disease is a chronic condition with a high prevalence in western countries. Transient lower esophageal sphincter relaxation episodes and a decreased lower esophageal sphincter pressure are the main mechanisms involved. Current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa879360d039c7ed638428c551d25e3
https://doi.org/10.2174/0929867324666170515123807

Interaction of 1-methyl-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl) piperidinium chloride with β-CD: spectroscopic, calorimetric and molecular modeling approaches

Autor: Adrian Pîrnău, Mihaela Mic, Irina Kacso, Mariana Palage, Maria Miclăuș, Mircea Bogdan, Călin G. Floare

Publikováno v: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 92:195-204

Spectroscopic investigation supported by molecular modeling methods has been used to describe the inclusion complex of β-cyclodextrin (β-CD) with 1-Methyl-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl) piperidinium chloride (1MPTMPC) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4435baa350654321d6f4c60eb562c94
https://doi.org/10.1007/s10847-018-0830-0

COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles

Autor: Alexandra M. Crăciun, Liliana Pacureanu, Elena-Luminita Crisan, Cristina Ioana Stoica, Laurentiu Răzvan Rusu, Smaranda Oniga, Cătălin Araniciu, Mariana Palage

Publikováno v: Molecules, Vol 22, Iss 9, p 1507 (2017)
Molecules; Volume 22; Issue 9; Pages: 1507
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit frequent and sometimes severe adverse effects, including gastrointestinal ulcerations and cardiovascular disorders. In an effort to obtain safer NSAIDs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d78897e585da59b5984088b57dda2d
https://www.mdpi.com/1420-3049/22/9/1507

Practice Experiences and Preceptor Behaviours in Pharmacy Education

Autor: Alina Maria Daraban, Simona Mirel, Mariana Palage, Liora Mihaiu

Publikováno v: Procedia - Social and Behavioral Sciences. 92:561-566

The aim of this study is to evaluate the significance of the training and mentoring of pharmacy students in order to improve these activities and to establish the adequate objectives in accordance with the changes concerning the concept of modern pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2334cfecc379ca78861df4b420e925