Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Mariana Nikolova-Karakashian"'
Autor:
Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El‐Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana Nikolova‐Karakashian, Erhard Bieberich
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H2O2 in Hela cells stimulated filopodia formation and the secretion of EVs
Externí odkaz:
https://doaj.org/article/c53528aac5d7474ba8f86592fc814ca0
Autor:
Nathalia Araujo, James Sledziona, Sunil K. Noothi, Ravshan Burikhanov, Nikhil Hebbar, Saptadwipa Ganguly, Tripti Shrestha-Bhattarai, Beibei Zhu, Wendy S. Katz, Yi Zhang, Barry S. Taylor, Jinze Liu, Li Chen, Heidi L. Weiss, Daheng He, Chi Wang, Andrew J. Morris, Lisa A. Cassis, Mariana Nikolova-Karakashian, Prabhakar R. Nagareddy, Olle Melander, B. Mark Evers, Philip A. Kern, Vivek M. Rangnekar
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par
Externí odkaz:
https://doaj.org/article/4120df1ef9614b949185e69e897e61c9
Autor:
Liansheng Zhong, Ji Na Kong, Michael B. Dinkins, Silvia Leanhart, Zhihui Zhu, Stefka D. Spassieva, Haiyan Qin, Hsuan-Pei Lin, Ahmed Elsherbini, Rebecca Wang, Xue Jiang, Mariana Nikolova-Karakashian, Guanghu Wang, Erhard Bieberich
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 5, Pp 795-804 (2018)
Sphingolipids are key signaling lipids in cancer. Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma. However, little is known about the sphingol
Externí odkaz:
https://doaj.org/article/5fdac2cab1a34351b8c39e1c023183be
Autor:
Taylor R. Valentino, Blake D. Rule, C. Brooks Mobley, Mariana Nikolova-Karakashian, Ivan J. Vechetti
Publikováno v:
Membranes, Vol 11, Iss 8, p 619 (2021)
We sought to characterize the lipid profile of skeletal muscle cell-derived Extracellular Vesicles (EVs) to determine if a hypertrophic stimulus would affect the lipid composition of C2C12 myotube-derived EVs. Analyses included C2C12 murine myoblasts
Externí odkaz:
https://doaj.org/article/87890b25fa8647edaf0b9fcc7d9ee9b6
Autor:
Gergana Deevska, Patrick P. Dotson, Mihail Mitov, D. Allan Butterfield, Mariana Nikolova-Karakashian
Publikováno v:
Cells, Vol 10, Iss 6, p 1278 (2021)
Ceramide and diacylglycerol (DAG) are bioactive lipids and mediate many cellular signaling pathways. Sphingomyelin synthase (SMS) is the single metabolic link between the two, while SMS2 is the only SMS form located at the plasma membrane. SMS2 funct
Externí odkaz:
https://doaj.org/article/34f5cdb06aa7402aaf9f58a6298ad50e
Autor:
Zhihui Zhu, Zainuddin Quadri, Simone M. Crivelli, Ahmed Elsherbini, Liping Zhang, Priyanka Tripathi, Haiyan Qin, Emily Roush, Stefka D. Spassieva, Mariana Nikolova-Karakashian, Timothy S. McClintock, Erhard Bieberich
Publikováno v:
Mol Neurobiol
We have shown that deficiency of neutral sphingomyelinase 2 (nSMase2), an enzyme generating the sphingolipid ceramide, improves memory in adult mice. Here, we performed sphingolipid and RNA-seq analyses on the cortex from 10-month-old nSMase2-deficie
Autor:
Ahmed Elsherbini, Zhang L, Simone M. Crivelli, Priyanka Tripathi, Erhard Bieberich, Zainuddin Quadri, Zhihui Zhu, Emily A. Roush, Stefka D. Spassieva, Mariana Nikolova-Karakashian, Haiyan Qin, Timothy S. McClintock
We have shown that deficiency of neutral sphingomyelinase 2 (nSMase2), an enzyme generating the sphingolipid ceramide, improves memory in adult mice. Here, we performed sphingolipid and RNA-seq analyses on the cortex from 10 month-old nSMase2-deficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7a5dea9ff1540e9ed03fd6d09688839
https://doi.org/10.1101/2021.06.08.445892
https://doi.org/10.1101/2021.06.08.445892
Autor:
Mariana Nikolova-Karakashian
Publikováno v:
Advances in Biological Regulation. 70:40-50
Sphingolipids are class of metabolically distinct lipids that play structural and signaling functions in all organisms. Sphingolipid metabolism is deregulated during various diseases such as cancer, neurological and immune disorders, and metabolic sy
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2187
This chapter will discuss methods for analyses of the rates of sphingomyelin synthesis and turnover associated with lipid rafts or plasma membrane. These methods involve the use of fluorescently (NBD-C6-ceramide or NBD-C6-Sphingomyelin)) or radioacti
Autor:
Mariana Nikolova-Karakashian
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608135
This chapter will discuss methods for analyses of the rates of sphingomyelin synthesis and turnover associated with lipid rafts or plasma membrane. These methods involve the use of fluorescently (NBD-C6-ceramide or NBD-C6-Sphingomyelin)) or radioacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3e14f22e811040e7194092e40b206c4
https://doi.org/10.1007/978-1-0716-0814-2_7
https://doi.org/10.1007/978-1-0716-0814-2_7