Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mariana N. Dimitrova"'
Publikováno v:
Challenges in Protein Product Development ISBN: 9783319906010
Biologics for treatment of a growing number acute and chronic conditions are often developed as parenteral injectables. Prefilled syringes (PFS) and other combination products offer patients the convenience of at-home self-administration. This can re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37261ae16c3341ef1379317937aa8116
https://doi.org/10.1007/978-3-319-90603-4_9
https://doi.org/10.1007/978-3-319-90603-4_9
Autor:
Douglas Johnson, Jared S. Bee, Kristin C. Jusino, Liu Tie, Christopher Douglas Afdahl, Mariana N. Dimitrova
Publikováno v:
Biotechnology Progress. 31:1360-1369
Chinese hamster ovary (CHO) cells are often used to produce therapeutic monoclonal antibodies (mAbs). CHO cells express many host cell proteins (HCPs) required for their growth. Interactions of HCPs with mAbs can sometimes result in co-purification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0538b3df2d465be02550cad78d2c5671
https://doi.org/10.1002/btpr.2150
https://doi.org/10.1002/btpr.2150
Autor:
Tzvetelina Chevolleau, Roberto A DePaz, Mariana N. Dimitrova, Roja Narwal, Sébastien Jouffray
Publikováno v:
Journal of Pharmaceutical Sciences. 103:1384-1393
Prefilled syringes (PFSs) offer improvements in the delivery of drugs to patients compared with traditional vial presentations and are becoming necessities in an increasingly competitive biologics market. However, the development of a product in a PF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8332e86ecebb0493f2d5b41bb450b8ce
https://doi.org/10.1002/jps.23947
https://doi.org/10.1002/jps.23947
Autor:
Mariana N. Dimitrova, Linda O. Narhi, Trace Tsuruda, Joseph Pollastrini, Xichdao Nguyen, Jie Wen, Jenny Li, Zai-Qing Wen, Cynthia Li, Yijia Jiang
Publikováno v:
Biochemistry. 51:10056-10065
The circulation half-life of a potential therapeutic can be increased by fusing the molecule of interest (an active peptide, the extracellular domain of a receptor, an enzyme, etc.) to the Fc fragment of a monoclonal antibody. For the fusion protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc6dde4a0a0f165d9a2fc08ed467d6d
https://doi.org/10.1021/bi300702e
https://doi.org/10.1021/bi300702e
Autor:
Mariana N. Dimitrova, Dean C. Ripple
Publikováno v:
Journal of Pharmaceutical Sciences. 101:3568-3579
All therapeutic protein products contain intrinsic particles formed by the aggregation of protein monomers. There is growing interest in understanding particles in biopharmaceutical products, fostered on one hand by significant advancements in partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4472bbbc685e57498ecb07485a2f0561
https://doi.org/10.1002/jps.23242
https://doi.org/10.1002/jps.23242
Publikováno v:
Journal of Biological Chemistry. 280:35424-35432
The functional form of ClpP, the proteolytic component of ATP-dependent Clp proteases, is a hollow-cored particle composed of two heptameric rings joined face-to-face forming an aqueous chamber containing the proteolytic active sites. We have found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15113488cbe30656dc93023adcf5b76
https://doi.org/10.1074/jbc.m507240200
https://doi.org/10.1074/jbc.m507240200
Publikováno v:
Thermochimica Acta. 420:37-43
The activity of enzyme I (EI), the first protein in the bacterial PEP:sugar phosphotransferase system, is regulated by a monomer–dimer equilibrium where a Mg2+-dependent autophosphorylation by PEP requires the homodimer. Using inactive EI(H189A), i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3f16b043b10a0f1f4c6bc35bc144a36
https://doi.org/10.1016/j.tca.2003.10.028
https://doi.org/10.1016/j.tca.2003.10.028
Autor:
Ann Ginsburg, Thomas E. Olszewski, John A. Hammer, Kirsten Remmert, M.Blair Bowers, Mariana N. Dimitrova
Publikováno v:
Journal of Biological Chemistry. 279:3068-3077
CARMIL, also known as Acan 125, is a multidomain protein that was originally identified on the basis of its interaction with the Src homology 3 (SH3) domain of type I myosins from Acanthamoeba. In a subsequent study of CARMIL from Dictyostelium, pull
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ffbe021fde956b89d802cfc896d56e
https://doi.org/10.1074/jbc.m308829200
https://doi.org/10.1074/jbc.m308829200
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 24:53-61
The interactions of bovine serum albumin, lysozyme and cytochrome c with phosphatidylcholine liposomes in liquid crystalline phase have been investigated using isothermal titration calorimetry in combination with steady state, and fluorescence measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce8b3bc8cf74e52d879939d627cc1be
https://doi.org/10.1016/s0927-7765(01)00248-x
https://doi.org/10.1016/s0927-7765(01)00248-x
Autor:
Stephan Krause, Jared S. Bee, Mariana N. Dimitrova, Paul Roussel, Jonathan Chung, Urooj Javed, Marta Corcoran, Vadim V. Frey, Steven M. Bishop, Patricia W. Cash
Publikováno v:
PDA journal of pharmaceutical science and technology. 68(5)
Glass prefillable syringes are lubricated with silicone oil to ensure functionality and a consistent injection for the end user. If excessive silicone is applied, droplets could potentially result in aggregation of sensitive biopharmaceuticals or clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faba69081c0b6d00c009e410a8b3533
https://pubmed.ncbi.nlm.nih.gov/25336420
https://pubmed.ncbi.nlm.nih.gov/25336420