Malaria parasite infection compromises control of concurrent systemic non-typhoidal Salmonella infection via IL-10-mediated alteration of myeloid cell function.

Autor: Kristen L Lokken, Jason P Mooney, Brian P Butler, Mariana N Xavier, Jennifer Y Chau, Nicola Schaltenberg, Ramie H Begum, Werner Müller, Shirley Luckhart, Renée M Tsolis

Publikováno v: PLoS Pathogens, Vol 10, Iss 5, p e1004049 (2014)

Non-typhoidal Salmonella serotypes (NTS) cause a self-limited gastroenteritis in immunocompetent individuals, while children with severe Plasmodium falciparum malaria can develop a life-threatening disseminated infection. This co-infection is a major

Externí odkaz: https://doaj.org/article/fa3a233f61834e62bf9cd43453497023

CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function.

Autor: Mariana N Xavier, Maria G Winter, Alanna M Spees, Kim Nguyen, Vidya L Atluri, Teane M A Silva, Andreas J Bäumler, Werner Müller, Renato L Santos, Renée M Tsolis

Publikováno v: PLoS Pathogens, Vol 9, Iss 6, p e1003454 (2013)

Evasion of host immune responses is a prerequisite for chronic bacterial diseases; however, the underlying mechanisms are not fully understood. Here, we show that the persistent intracellular pathogen Brucella abortus prevents immune activation of ma

Externí odkaz: https://doaj.org/article/5ed1732597184f0ca17a17836e3a9943

Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance.

Autor: Robert W Crawford, A Marijke Keestra, Sebastian E Winter, Mariana N Xavier, Renée M Tsolis, Vladimir Tolstikov, Andreas J Bäumler

Publikováno v: PLoS Pathogens, Vol 8, Iss 9, p e1002918 (2012)

Intestinal inflammation changes the luminal habitat for microbes through mechanisms that have not been fully resolved. We noticed that the FepE regulator of very long O-antigen chain assembly in the enteric pathogen Salmonella enterica serotype Typhi

Externí odkaz: https://doaj.org/article/3c0c8fd6b1974efc8a76a30ce709da1d

Neutrophils Are a Source of Gamma Interferon during Acute Salmonella enterica Serovar Typhimurium Colitis

Autor: Tamding Wangdi, Dawn D. Kingsbury, Alanna M. Spees, Renée M. Tsolis, Andreas J. Bäumler, Mariana N. Xavier

Publikováno v: Infection and immunity, vol 82, iss 4
Spees, AM; Kingsbury, DD; Wangdi, T; Xavier, MN; Tsolis, RM; & Bäumler, AJ. (2014). Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar typhimurium colitis. Infection and Immunity, 82(4), 1692-1697. doi: 10.1128/IAI.01508-13. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9b1687pm

Gamma interferon (IFN-γ) is an important driver of intestinal inflammation during colitis caused by Salmonella enterica serovar Typhimurium. Here we used the mouse colitis model to investigate the cellular sources of IFN-γ in the cecal mucosa durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcff12911a6d800ef978e6749ac6465
https://doi.org/10.1128/iai.01508-13

Innate immune recognition of flagellin limits systemic persistence ofBrucella

Autor: Jonathan Ferooz, Vidya L. Atluri, Mariana N. Xavier, Gabriel Núñez, Matthieu Terwagne, Luigi Franchi, Richard A. Flavell, Xavier De Bolle, Renée M. Tsolis, Jean-Jacques Letesson, Yao Hui Sun, Thomas Legrand, Hortensia G. Rolán

Publikováno v: Cellular Microbiology. 15:942-960

Brucella are facultative intracellular bacteria that cause chronic infections by limiting innate immune recognition. It is currently unknown whether Brucella FliC flagellin, the monomeric subunit of flagellar filament, is sensed by the host during in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::242324dbb0e1c77ef6895b939280f003
https://doi.org/10.1111/cmi.12088