Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mariana Mihalusova"'
Publikováno v:
Biophysical Journal. 102(3)
Telomerase is a cellular ribonucleoprotein (RNP) complex comprised of telomerase RNA, telomerase reverse transcriptase (TERT) and other protein cofactors. The activity of the telomerase enzyme is essential for the maintenance of genome stability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8809eb5a950f6444a1cbb2c60f106f7
Telomerase ribonucleoprotein (RNP) employs an RNA subunit to template the addition of telomeric repeats onto chromosome ends. Previous studies have suggested that a region of the RNA downstream of the template may be important for telomerase activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdddde103280d756794026a75576b765
https://europepmc.org/articles/PMC3251044/
https://europepmc.org/articles/PMC3251044/
Publikováno v:
Biophysical Journal. 96(3)
Telomerase, a ribonucleoprotein (RNP) expressed in all highly proliferating cells, is comprised of telomerase RNA, telomerase reverse transcriptase (TERT) and other protein cofactors. The complex compensates for the chromosomal shortening that arises
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc9d24f8d445a1644badcfc9829466d
Autor:
Mariana Mihalusova, Xiaowei Zhuang, Catherine M. O'Connor, Ramadevi Prathapam, Kathleen Collins, Michael D. Stone
Publikováno v:
Nature. 446(7134)
The biogenesis of telomerase, the ribonucleoprotein (RNP) assembly that stabilizes the termini of linear chromosomes, is an important process in a healthy cell and mutations that disrupt it cause disease. Mechanisms of RNP assembly are poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c3b14347bbef11496c8911815d0801
https://pubmed.ncbi.nlm.nih.gov/17322903
https://pubmed.ncbi.nlm.nih.gov/17322903
Publikováno v:
Biophysical Journal. 96:416a
Telomerase is a cellular ribonucleoprotein reverse transcriptase catalyzing the addition of telomeric repeats onto chromosome ends. Given its role in maintaining genomic stability and replicative capacity of cells, telomerase is implicated in cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b794163570b830e599f5e30aedade78
https://doi.org/10.1016/j.bpj.2008.12.2126
https://doi.org/10.1016/j.bpj.2008.12.2126