Výsledky vyhledávání - "Mariana Margenat"

Akademický článek

Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism

Autor: Mariana Margenat, Gabriela Betancour, Vivian Irving, Alicia Costábile, Tania García-Cedrés, María Magdalena Portela, Federico Carrión, Fernando E. Herrera, Andrea Villarino

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

During Mycobacterium tuberculosis (Mtb) infection, the virulence factor PtpA belonging to the protein tyrosine phosphatase family is delivered into the cytosol of the macrophage. PtpA interacts with numerous eukaryotic proteins modulating phagosome m

Externí odkaz: https://doaj.org/article/0571fb21ae35490b9f1fb55ee0ea9b99

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Akademický článek

Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels.

Autor: Martín Fló, Mariana Margenat, Leonardo Pellizza, Martín Graña, Rosario Durán, Adriana Báez, Emilio Salceda, Enrique Soto, Beatriz Alvarez, Cecilia Fernández

Publikováno v: PLoS Pathogens, Vol 13, Iss 2, p e1006169 (2017)

We previously reported a multigene family of monodomain Kunitz proteins from Echinococcus granulosus (EgKU-1-EgKU-8), and provided evidence that some EgKUs are secreted by larval worms to the host interface. In addition, functional studies and homolo

Externí odkaz: https://doaj.org/article/d5c39f5af6804df6832342bb9c11ba76

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Akademický článek

A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk.

Autor: Silvia González, Martín Fló, Mariana Margenat, Rosario Durán, Gualberto González-Sapienza, Martín Graña, John Parkinson, Rick M Maizels, Gustavo Salinas, Beatriz Alvarez, Cecilia Fernández

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e7009 (2009)

The cestode Echinococcus granulosus, the agent of hydatidosis/echinococcosis, is remarkably well adapted to its definitive host. However, the molecular mechanisms underlying the successful establishment of larval worms (protoscoleces) in the dog duod

Externí odkaz: https://doaj.org/article/65a327fae1074982a57a3842cd396aaa

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Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels

Autor: Enrique Soto, Rosario Durán, Emilio Salceda, Leonardo Pellizza, Martín Graña, Mariana Margenat, Cecilia Fernández, Adriana Báez, Beatriz Alvarez, Martín Fló

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
COLIBRI
Universidad de la República
instacron:Universidad de la República
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 2, p e1006169 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465530f4c06e3dd8e1ab506f4b4b671f
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006169

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Tuned Escherichia coli as a host for the expression of disulfide-rich proteins

Autor: Martín Fló, Leonardo Pellizza, Cecilia Fernández, Gustavo Salinas, Mariana Margenat

Publikováno v: Biotechnology Journal. 6:686-699

Disulfide-bond formation is a major post-translational modification and is essential for protein folding, stability, and function. This is especially true for secreted proteins, many of which possess great potential for biotechnological applications.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d735f8d8b6b2062c02c48856b20d03fe
https://doi.org/10.1002/biot.201000335

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New potential eukaryotic substrates of the mycobacterial protein tyrosine phosphatase PtpA: hints of a bacterial modulation of macrophage bioenergetics state

Autor: María Magdalena Portela, Gonzalo Obal, Anne-Marie Labandera, Ana M. Ferreira, Federico Carrion, Magdalena Gil, Mariana Margenat, Hernán Terenzi, Andrea Villarino, Guilherme Razzera, Otto Pritsch, Rosario Durán, Marcela Purificação

Publikováno v: Scientific Reports

The bacterial protein tyrosine phosphatase PtpA is a key virulence factor released by Mycobacterium tuberculosis in the cytosol of infected macrophages. So far only two unrelated macrophage components (VPS33B, GSK3α) have been identified as PtpA sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019cf67fc1d0d86940dcc51aa8e1a46a
http://europepmc.org/articles/PMC5390082

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A Family of Diverse Kunitz Inhibitors from Echinococcus granulosus Potentially Involved in Host-Parasite Cross-Talk

Autor: John Parkinson, Martín Fló, Cecilia Fernández, Silvia González, Rosario Durán, Rick M. Maizels, Beatriz Alvarez, Martín Graña, Gualberto González-Sapienza, Gustavo Salinas, Mariana Margenat

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e7009 (2009)
PLoS ONE
PLoS ONE, Public Library of Science, 2009, 4 (9), pp.e7009. ⟨10.1371/journal.pone.0007009⟩

International audience; The cestode Echinococcus granulosus, the agent of hydatidosis/echinococcosis, is remarkably well adapted to its definitive host. However, the molecular mechanisms underlying the successful establishment of larval worms (protos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18c9b52fdba26a410b301a914261c52
https://doi.org/10.1371/journal.pone.0007009

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