Kinetics of Leptospira interrogans infection in hamsters after intradermal and subcutaneous challenge.

Autor: Mariana L Coutinho, James Matsunaga, Long-Chieh Wang, Alejandro de la Peña Moctezuma, Michael S Lewis, Jane T Babbitt, Jose Antonio G Aleixo, David A Haake

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3307 (2014)

Leptospirosis is a zoonosis caused by highly motile, helically shaped bacteria that penetrate the skin and mucous membranes through lesions or abrasions, and rapidly disseminate throughout the body. Although the intraperitoneal route of infection is

Externí odkaz: https://doaj.org/article/2605c30656664d349f0a841e487f528a

Testing different antigen capture ELISA formats for detection of Leptospira spp. in human blood serum

Autor: Leonardo Garcia Monte, Éverton Fagonde da Silva, Odir Antônio Dellagostin, Flávia Aleixo Vasconcellos, Mariana L. Coutinho, Cláudia Pinho Hartleben Fernandes, Núbia Seyffert, José Antonio Guimarães Aleixo

Publikováno v: Transactions of the Royal Society of Tropical Medicine and Hygiene. 104:259-264

Leptospirosis is an infectious disease caused by pathogenic spirochetes of the genus Leptospira. The illness is characterized by an acute bacteremic phase followed by an immune phase, in which specific antibodies are found in blood and leptospires ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cd4e241797ce32c5363fdc4b69c580
https://doi.org/10.1016/j.trstmh.2009.10.005

Monoclonal antibodies against the leptospiral immunoglobulin-like proteins A and B conserved regions

Autor: Odir Antônio Dellagostin, Fabiana Kömmling Seixas, Leonardo Garcia Monte, Mariana L. Coutinho, Fabricio Rochedo Conceição, Luis A.S. deCastro, Cláudia Pinho Hartleben, Éverton Fagonde da Silva, José Antonio Guimarães Aleixo, Flávia Aleixo Vasconcellos

Publikováno v: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA

Leptospirosis is an infectious disease caused by pathogenic spirochetes of the genus Leptospira that affects humans and a wide variety of animals. Recently the genomes of Leptospira interrogans, Leptospira borgpetersenii and Leptospira biflexa specie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288b0aef2a649d895025b417fffe8aa6
https://pubmed.ncbi.nlm.nih.gov/21903270

Evaluation of the anti-LipL32 monoclonal antibodies potential for use in leptospirosis immunodiagnostic tests

Autor: Fabiana Kömmling Seixas, Flávia Aleixo Vasconcellos, Cláudia Pinho Hartleben Fernandes, Núbia Seyffert, Albert I. Ko, Mariana L. Coutinho, José Antonio Guimarães Aleixo, Odir Antônio Dellagostin

Publikováno v: Journal of immunoassayimmunochemistry. 28(3)

LipL32 is the major lipoprotein in the membrane of pathogenic leptospira. In this work, we report on the production of monoclonal antibodies (MAbs) against recombinant LipL32 (rLipL32) and on the evaluation of their potential for use as reagents in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6538b6e2ec415786f98d9bfc9a3ea3be
https://pubmed.ncbi.nlm.nih.gov/17613673

A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans

Autor: Michael S. Lewis, Henry A. Choy, Melissa M. Kelley, Mariana L. Coutinho, Jane T. Babbitt, James Matsunaga, David A. Haake, José Antonio Guimarães Aleixo

Publikováno v: PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1422 (2011)
PLoS Neglected Tropical Diseases

The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972fb9291cb6417d1a4825ca0d232e19
https://doi.org/10.1371/journal.pntd.0001422