Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mariana G Tarragó"'
Autor:
Antoine deZélicourt, Abdallah Fayssoil, Mbarka Dakouane‐Giudicelli, Isley De Jesus, Ahmed Karoui, Faouzi Zarrouki, Florence Lefebvre, Arnaud Mansart, Jean‐Marie Launay, Jerome Piquereau, Mariana G Tarragó, Marcel Bonay, Anne Forand, Sophie Moog, France Piétri‐Rouxel, Elise Brisebard, Claudia C S Chini, Sonu Kashyap, Matthew J Fogarty, Gary C Sieck, Mathias Mericskay, Eduardo N Chini, Ana Maria Gomez, José‐Manuel Cancela, Sabine de laPorte
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp n/a-n/a (2022)
Abstract Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration. Two important deleterious features are a Ca2+ dysregulation linked to Ca2+ influxes associated with ryanodine receptor hyperactivation, and a muscular nic
Externí odkaz:
https://doaj.org/article/ff8aa5831114408f802cc62d7a45fce4
Autor:
D. Povero, Roger K. Moreira, Gina M. Warner, Karina S. Kanamori, E. H. Cheek, Eduardo N. Chini, Michael Torbenson, Taofic Mounajjed, M. F. Chedid, Sarah M. Jenkins, Rondell P. Graham, B. D. Sabat, A. Jones, Julie K. Heimbach, Mariana G. Tarragó
Publikováno v:
Laboratory Investigation. 101:1098-1109
Steatosis is the most important prognostic histologic feature in the setting of liver procurement. The currently utilized diagnostic methods, including gross evaluation and frozen section examination, have important shortcomings. Novel techniques tha
Autor:
Guilherme C. de Oliveira, Tamara Tchkonia, Karthikeyani Chellappa, Karina S. Kanamori, Connor Jankowski, Katie L. Thompson, Guillermo Agorrody, Joshua D. Rabinowitz, Amrutesh S. Puranik, James L. Kirkland, Jan M. van Deursen, Kevin Dang, Gina M. Warner, Claudia C.S. Chini, Micaela A. Witte, Eduardo N. Chini, Lilian S Gomez, Starlynn Clarke, Thais Peclat, Jair Machado Espindola-Netto, Melanie R. McReynolds, Kelly A. Hogan, Marco De Cecco, Wim Van Schooten, Darren J. Baker, Paola Vidal, Bennett G. Childs, Sonu Kashyap, Mariana G. Tarragó, Joseph A. Baur, Anna L. Kirkland, John M. Sedivy
Publikováno v:
Nature metabolism
Decreased nicotinamide adenine dinucleotide (NAD+) levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated duri
Autor:
Thais R. Peclat, Katie L. Thompson, Gina M. Warner, Claudia C.S. Chini, Mariana G. Tarragó, Delaram Z. Mazdeh, Chunlian Zhang, Jose Zavala‐Solorio, Ganesh Kolumam, Yao Liang Wong, Robert L. Cohen, Eduardo N. Chini
Publikováno v:
Aging cell. 21(4)
Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age-related NAD decline. Whether the inhibition of CD38 increases lifespan is not known. Here
Autor:
Claudia C.S. Chini, Eduardo N. Chini, Kelly A. Hogan, Mariana G. Tarragó, Tamar Tchkonia, James L. Kirkland, Gina M. Warner, Thais Peclat
Publikováno v:
Biochemical and Biophysical Research Communications. 513:486-493
Tissue nicotinamide adenine dinucleotide (NAD(+)) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved in tissue NAD(+) decline during the aging process. CD38 is an ecto-enzyme highly expressed in end
Autor:
Shamit K. Dutta, Claudia C.S. Chini, Enfeng Wang, Debabrata Mukhopadhyay, Eduardo N. Chini, Jair Machado Espindola-Netto, Mauro Sola-Penna, Krishnendu Pal, Mariana G. Tarragó
Publikováno v:
Oncotarget
NAD salvage is one of the pathways used to generate NAD in mammals. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in this pathway, uses nicotinamide (NAM) to generate nicotinamide mononucleotide (NMN). NMN is one of the mai
Autor:
Kun Ling, Nino Giorgadze, Eduardo N. Chini, Yingyi Zhang, Thais Peclat, Jinghua Hu, James L. Kirkland, Gina M. Warner, Jielu Hao, Kai He, Mariana G. Tarragó, Qing Wei, Yan Huang, Thomas A. White, Tamar Tchkonia, Chuan Chen
Publikováno v:
Cell reports
SUMMARY Preadipocytes dynamically produce sensory cilia. However, the role of primary cilia in preadipocyte differentiation and adipose homeostasis remains poorly understood. We previously identified transition fiber component FBF1 as an essential pl
Publikováno v:
Drug Metabolism and Disposition. 44:1742-1751
Overdose of isoniazid (INH), an antituberculosis drug, can be life-threatening because of neurotoxicity. In clinical practice for management of INH overdose and acute toxicity, the potential of INH-induced hepatotoxicity is also considered. However,
Autor:
Claudia C.S. Chini, Joel M. Reid, Eduardo N. Chini, Gina M. Warner, Veronica Nin, Amrutesh S. Puranik, Carlos Escande, Renee A. Schoon, Antonio Galina, Juliana Camacho-Pereira, Mariana G. Tarragó
Publikováno v:
Cell Metabolism. 23:1127-1139
Nicotinamide Adenine Dinucleotide (NAD) levels decrease during aging, and are involved in age-related metabolic decline. To date, the mechanism responsible for the age-related reduction in NAD has not been elucidated. Here we demonstrate that express
Publikováno v:
Molecular and cellular endocrinology. 455
Life as we know it cannot exist without the nucleotide nicotinamide adenine dinucleotide (NAD). From the simplest organism, such as bacteria, to the most complex multicellular organisms, NAD is a key cellular component. NAD is extremely abundant in m