Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mariana Capurro"'
Publikováno v:
Annual Review of Physiology. 84:485-506
The body depends on its physical barriers and innate and adaptive immune responses to defend against the constant assault of potentially harmful microbes. In turn, successful pathogens have evolved unique mechanisms to adapt to the host environment a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96f55bf5126b559fab1276806a077e00
https://doi.org/10.1146/annurev-physiol-061121-035930
https://doi.org/10.1146/annurev-physiol-061121-035930
Autor:
Akriti Prashar, Iram Siddiqui, Adam Hwa-Ming Hsieh, Dana M. Bronte-Tinkew, Ana Lozano-Ruf, Daniel E Roth, Peter C Church, Frances Dang, Amanda Ricciuto, Anne M. Griffiths, Thomas D. Walters, Nicola L. Jones, Laura Greenfield, Laurel McGillis, Dana J. Philpott, Mariana Capurro
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 321(2)
Vitamin D deficiency is an environmental factor involved in the pathogenesis of inflammatory bowel disease (IBD); however, the mechanisms surrounding its role remain unclear. Previous studies conducted in an intestinal epithelial-specific vitamin D r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239b429f78e6ac8bc2fa1cbe56261b48
https://pubmed.ncbi.nlm.nih.gov/34159811
https://pubmed.ncbi.nlm.nih.gov/34159811
Autor:
David Rizzuti, Mariana Capurro, Majd Abdullah, Dana M. Bronte-Tinkew, Laura Greenfield, Nicola L. Jones
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Helicobacter pylori (H. pylori) is the causative agent of gastric cancer, making it the only bacterium to be recognized as a Class I carcinogen by the World Health Organization. The virulence factor cytotoxin associated gene A (CagA) is a known oncop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce4e95843442f1106f56e24adbcb9e0
http://link.springer.com/article/10.1038/s41598-018-37095-4
http://link.springer.com/article/10.1038/s41598-018-37095-4
Autor:
Marzena Cydzik, Luisa Bonafé, Mariana Capurro, Philippe Suarez, Tomomi Izumikawa, Wen Shi, Jorge Filmus, Jean Gariépy, Tomoyuki Kaneiwa
Publikováno v:
The Journal of cell biology, vol. 216, no. 9, pp. 2911-2926
The Journal of Cell Biology
The Journal of Cell Biology
Autosomal-recessive omodysplasia (OMOD1) is caused by mutations in glypican-6. Capurro et al. show that glypican-6 stimulates Hedgehog (Hh) signaling, and reduced Hh signaling may contribute to the pathogenesis of OMOD1.
Autosomal-recessive omod
Autosomal-recessive omod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548e0bb0cd399fa3de9c367444cf10a0
https://doi.org/10.1083/jcb.201605119
https://doi.org/10.1083/jcb.201605119
Autor:
Iram Siddiqui, Majd Abdullah, Michael A. Helmrath, Nicola L. Jones, Akriti Prashar, Dana J. Philpott, Xianping Dong, Harikesh S. Wong, Lisa A. Robinson, Yana Zavros, Nina Bertaux-Skeirik, Jayati Chakrabarti, Richard M. Peek, Catherine A. O’Brien, Laura Greenfield, Mariana Capurro, Sunny Xia, Xi Zoe Zhong
Publikováno v:
Nat Microbiol
Helicobacter pylori infection is a proven carcinogen for gastric cancer. Its virulence factor vacuolating cytotoxin A (VacA) promotes more severe disease and gastric colonization. VacA, by an unknown mechanism, usurps lysosomal and autophagy pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b360e3b8ee36058707088d3c0f2fc5a
https://europepmc.org/articles/PMC6938649/
https://europepmc.org/articles/PMC6938649/
Autor:
I Verapalan, Dana M. Bronte-Tinkew, R Murchie, Adam Hwa-Ming Hsieh, Dana J. Philpott, Laura Greenfield, Laurel McGillis, Nicola L. Jones, Mariana Capurro, Frances Dang
BACKGROUND: Growing evidence from animal and human studies indicate that vitamin D deficiency is an important environmental factor contributing to IBD pathogenesis. The exact mechanism underlying the role of vitamin D in IBD is currently unknown. AIM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc83bb98117a7c3480bdc8f85812826a
https://europepmc.org/articles/PMC6508410/
https://europepmc.org/articles/PMC6508410/
BACKGROUND: Helicobacter pylori (H. pylori) is a proven carcinogen for gastric cancer. The vacuolating cytotoxin A (VacA) is a bacterial virulence factor that promotes more severe disease and gastric colonization. VacA generates a unique reservoir fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312c248bb4329c779fb21d257de3aa64
https://europepmc.org/articles/PMC6508393/
https://europepmc.org/articles/PMC6508393/
Publikováno v:
Autophagy. 16:169-170
Inhibition of host macroautophagy/autophagy is one of the strategies used by several intracellular pathogens, including H. pylori, to escape killing. Here we discuss our recent work that revealed the novel mechanism by which the vacuolating cytotoxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5934a5e2c5735a9da56d4d68cbcd182
https://doi.org/10.1080/15548627.2019.1677322
https://doi.org/10.1080/15548627.2019.1677322
Publikováno v:
Journal of Biological Chemistry. 290:7576-7585
Glypican-3 (GPC3) is one of the six members of the mammalian glypican family. We have previously reported that GPC3 inhibits Hedgehog (Hh) signaling by competing with Patched (Ptc) for Hh binding. We also showed that GPC3 binds with high affinity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c343bd368b7036aa5eac512104093e
https://doi.org/10.1074/jbc.m114.612705
https://doi.org/10.1074/jbc.m114.612705
Autor:
Jorge Filmus, Mariana Capurro
Publikováno v:
Matrix Biology. 35:248-252
Glypicans (GPCs) are a family of proteoglycans that are bound to the cell surface by a glycosylphosphatidylinositol anchor. Six glypicans have been found in the mammalian genome (GPC1 to GPC6). GPCs regulate several signaling pathways, including the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5cb4ea8c28f9304b031c5b82a3c93b