Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mariana C. Rocha"'
Autor:
Sasiharan Sithamparanathan, Mariana C. Rocha, Jehill D. Parikh, Karolina A. Rygiel, Gavin Falkous, John P. Grady, Kieren G. Hollingsworth, Michael I. Trenell, Robert W. Taylor, Doug M. Turnbull, Gráinne S. Gorman, Paul A. Corris
Publikováno v:
Pulmonary Circulation, Vol 8 (2018)
Mitochondrial dysfunction within the pulmonary vessels has been shown to contribute to the pathology of idiopathic pulmonary arterial hypertension (IPAH). We investigated the hypothesis of whether impaired exercise capacity observed in IPAH patients
Externí odkaz:
https://doaj.org/article/f216b8c43e6944f8b86eb2a43ebf75c8
Autor:
Francesco Bruni, Kyle Thompson, Grainne S. Gorman, Ewen W. Sommerville, Ilaria Dalla Rosa, Robert W. Taylor, Patrick F. Chinnery, Andrew M. Schaefer, Patrick Yu-Wai-Man, Masha M. Rosenberg, Mariana C. Rocha, Lizbeth Hedstrom, Langping He, Gavin Falkous, Emma L. Blakely, Antonella Spinazzola
Publikováno v:
Clinical Genetics
Autosomal dominant progressive external ophthalmoplegia (adPEO) is a late‐onset, Mendelian mitochondrial disorder characterised by paresis of the extraocular muscles, ptosis, and skeletal‐muscle restricted multiple mitochondrial DNA (mtDNA) delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e087aa81b30b8224181eba9d45ffdd
https://doi.org/10.1111/cge.13652
https://doi.org/10.1111/cge.13652
Autor:
Roger Springett, Mariana C. Rocha
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1860:89-101
The proton pumps of the mitochondrial electron transport chain (ETC) convert redox energy into the proton motive force (ΔP), which is subsequently used by the ATP synthase to regenerate ATP. The limited available redox free energy requires the proto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fabec5f09927546074df73379ac260
https://doi.org/10.1016/j.bbabio.2018.11.013
https://doi.org/10.1016/j.bbabio.2018.11.013
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73846 (2013)
Amyotrophic lateral sclerosis is characterized by a progressive degeneration of the corticospinal tract motor neurons. Growing evidence suggests that degeneration may begin at the distal axon proceeding in a dying-back pattern. It seemed therefore of
Externí odkaz:
https://doaj.org/article/908587d8d207498c86ddfd66b7a5a01f
Autor:
Andrew M. Schaefer, Masha M. Rosenberg, Mariana C. Rocha, Robert W Taylor, Ewen Sommerville, Patrick Yu-Wai-Man, Lizbeth Hedstrom, Emma L. Blakely, Grainne S. Gorman, Patrick F. Chinnery, Ilaria Dalla Rosa, Antonella Spinazzola, Langping He, Francesco Bruni, Kyle Thompson, Gavin Falkous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3628857af48b55ce38bdb966025bce4f
https://doi.org/10.1111/cge.13652/v2/response1
https://doi.org/10.1111/cge.13652/v2/response1
Autor:
Stephan Zierz, Hal Tuppen, Amy E. Vincent, Mariana C. Rocha, Douglass M. Turnbull, Diana Lehmann, Georgia Campbell, Robert W. Taylor, Hannah S. Rosa
Publikováno v:
Nervenheilkunde.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0837fb821bdd4b6f57a2a259d98b87b3
https://doi.org/10.1055/s-0039-1685055
https://doi.org/10.1055/s-0039-1685055
Autor:
Amy E. Vincent, Robert W. Taylor, Hannah S. Rosa, Douglass M. Turnbull, D. Lehmann, Mariana C. Rocha, Stephan Zierz
Publikováno v:
Clinical Neurophysiology. 131:e179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0572c5ddd843e6b3bfe85b27d5655306
https://doi.org/10.1016/j.clinph.2019.12.008
https://doi.org/10.1016/j.clinph.2019.12.008
Autor:
Helen A. L. Tuppen, Thomas J. Nicholls, Hannah S. Rosa, Marcus Deschauer, Robert W. Taylor, Charlotte L. Alston, Diana Lehmann, Amy K. Reeve, Amy E. Vincent, Georgia Campbell, Conor Lawless, Mariana C. Rocha, Douglass M. Turnbull, Stephan Zierz
Publikováno v:
Nucleic Acids Research
Clonal expansion of mitochondrial DNA (mtDNA) deletions is an important pathological mechanism in adults with mtDNA maintenance disorders, leading to a mosaic mitochondrial respiratory chain deficiency in skeletal muscle. This study had two aims: (i)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fe20aadfd67ab01064285b2a5a7b3d
https://mediatum.ub.tum.de/1544866
https://mediatum.ub.tum.de/1544866
Autor:
Roger Springett, Mariana C. Rocha
Publikováno v:
Rocha, M & Springett, R 2018, ' Electron transfer between cytochrome c and the binuclear center of cytochrome oxidase ', Journal of Theoretical Biology . https://doi.org/10.1016/j.jtbi.2018.10.022
The Minnaert model, which can account for the reaction kinetics between cytochrome oxidase and cytochrome c (Cytc), has been used to justify equal binding rate constants for reduced and oxidized Cytc. Here we extend the model beyond reversible bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf47d16423cc382afaeb06e99c7767d
https://pubmed.ncbi.nlm.nih.gov/30315812
https://pubmed.ncbi.nlm.nih.gov/30315812
Autor:
Michael I. Trenell, Jehill D Parikh, Sasiharan Sithamparanathan, Karolina A. Rygiel, John P. Grady, Kieren G. Hollingsworth, Robert W. Taylor, Mariana C. Rocha, Grainne S. Gorman, Paul A. Corris, Gavin Falkous, Douglass M. Turnbull
Publikováno v:
Pulmonary Circulation, Vol 8 (2018)
Pulmonary Circulation
Pulmonary Circulation
Mitochondrial dysfunction within the pulmonary vessels has been shown to contribute to the pathology of idiopathic pulmonary arterial hypertension (IPAH). We investigated the hypothesis of whether impaired exercise capacity observed in IPAH patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a014eb7cf80d5252564a7fa8d7cc2b8e
https://doaj.org/article/f216b8c43e6944f8b86eb2a43ebf75c8
https://doaj.org/article/f216b8c43e6944f8b86eb2a43ebf75c8