Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mariana C. Fiori"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Membrane proteins (MPs) are essential to many organisms’ major functions. They are notorious for being difficult to isolate and study, and mimicking native conditions for studies in vitro has proved to be a challenge. Lipid nanodiscs are among the
Externí odkaz:
https://doaj.org/article/6c244f0aea244dc3b0658ac166d05f12
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Styrene-maleic acid copolymers allow for solubilization and reconstitution of membrane proteins into nanodiscs. These polymer-encased nanodiscs are promising platforms for studies of membrane proteins in a near-physiologic environment withou
Externí odkaz:
https://doaj.org/article/a51c6437cf824dffbda713530a5202a9
Autor:
Mariana C. Fiori, Srinivasan Krishnan, Abbey Kjellgren, Luis G. Cuello, Guillermo A. Altenberg
Publikováno v:
Molecules, Vol 22, Iss 12, p 2063 (2017)
In addition to gap junctional channels that mediate cell-to-cell communication, connexins form hemichannels that are present at the plasma membrane. Since hemichannels are permeable to small hydrophilic compounds, including metabolites and signaling
Externí odkaz:
https://doaj.org/article/5c1c3336fcec448b8c09b6046c450258
Autor:
Ainoa Fernández-Olivares, Eduardo Durán-Jara, Daniel A. Verdugo, Mariana C. Fiori, Guillermo A. Altenberg, Jimmy Stehberg, Iván Alfaro, Juan Francisco Calderón, Mauricio A. Retamal
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7252
Connexin (Cxs) hemichannels participate in several physiological and pathological processes, but the molecular mechanisms that control their gating remain elusive. We aimed at determining the role of extracellular cysteines (Cys) in the gating and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e9db387e3076834f76cc52935d07f9
https://pubmed.ncbi.nlm.nih.gov/35806258
https://pubmed.ncbi.nlm.nih.gov/35806258
Autor:
Mariana C. Fiori, Guillermo A. Altenberg, Elizabeth Kamilar, Hongjun Liang, Wan Zheng, Geuel Simiyu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Membrane proteins can be reconstituted in polymer-encased nanodiscs for studies under near-physiological conditions and in the absence of detergents, but traditional styrene-maleic acid copolymers used for this purpose suffer severely from buffer inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea71a0479a0a77b6701a54af07dcc2f
http://link.springer.com/article/10.1038/s41598-020-66852-7
http://link.springer.com/article/10.1038/s41598-020-66852-7
Autor:
Mariana C. Fiori, Cristina M. Natha, Varun Vemulapalli, Guillermo A. Altenberg, Cheng-Wei Tom Chang
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1867(6)
Connexins are membrane proteins involved directly in cell-to-cell communication through the formation of gap-junctional channels. These channels result from the head-to-head docking of two hemichannels, one from each of two adjacent cells. Undocked h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdbd0b5948c0e420ff7a32e9bc4159d5
https://pubmed.ncbi.nlm.nih.gov/33711451
https://pubmed.ncbi.nlm.nih.gov/33711451
Autor:
Cheng-Wei Tom Chang, Guillermo A. Altenberg, Paul Roberts, Heath Montgomery, Abbey Kjellgren, Noah Thackeray, Mariana C. Fiori, Yagya Prasad Subedi
Publikováno v:
European journal of medicinal chemistry. 203
Gap junction channels formed by the association of connexin hemichannels play a crucial role in intercellular communication. Connexin 43 (Cx43) is expressed in a variety of tissues and organs, including heart and brain, and abnormal sustained opening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61597cc20d3de5cf19ab90a16a31811
https://pubmed.ncbi.nlm.nih.gov/32679454
https://pubmed.ncbi.nlm.nih.gov/32679454
Autor:
Mauricio A. Retamal, Sergio Linsambarth, Ainoa Fernandez-Olivares, Mariana C. Fiori, Francisca Peña, Jimmy Stehberg, Guillermo A. Altenberg, Daisy Quintana
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1865(8)
Hemichannels formed by connexins mediate the exchange of ions and signaling molecules between the cytoplasm and the extracellular milieu. Under physiological conditions hemichannels have a low open probability, but in certain pathologies their open p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681cb3f62ed17eb219d011ef0af440f2
https://pubmed.ncbi.nlm.nih.gov/32244060
https://pubmed.ncbi.nlm.nih.gov/32244060
Autor:
Mario J. Borgnia, Guillermo A. Altenberg, Miguel Anzaldua, Hongjun Liang, Mariana C. Fiori, Yunjiang Jiang, Wan Zheng
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific Reports
Lipid nanodiscs are playing increasingly important roles in studies of the structure and function of membrane proteins. Development of lipid nanodiscs as a membrane-protein-supporting platform, or a drug targeting and delivery vehicle in general, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062067e04ffd11a3f266567bde9b51b9
http://link.springer.com/article/10.1038/s41598-017-15151-9
http://link.springer.com/article/10.1038/s41598-017-15151-9
Autor:
Mariana C. Fiori, D. Marien Cortes, Guillermo A. Altenberg, Ty Whisenant, Luis G. Cuello, Srinivasan Krishnan
Publikováno v:
SLAS Discovery. 22:135-143
Connexins form the gap junctional channels that mediate cell-to-cell communication, and also form hemichannels present at the plasma membrane. Hemichannels are permeable to small hydrophilic compounds, including molecules involved in autocrine and pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4181c765267193a86965e51c5170b97c
https://doi.org/10.1177/1087057116675321
https://doi.org/10.1177/1087057116675321