Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mariana C Gadaleta"'
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1007013 (2017)
The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5'-phosphate and 3'-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known as
Externí odkaz:
https://doaj.org/article/080a3790097c41548754bdb493dc6f6f
Autor:
Mariana C Gadaleta, Mukund M Das, Hideki Tanizawa, Ya-Ting Chang, Ken-ichi Noma, Toru M Nakamura, Eishi Noguchi
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005943 (2016)
Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication stress, such as fork stalling and collapse, can be induced at natural replication impediments pre
Externí odkaz:
https://doaj.org/article/c6127aa80e8249ceb911268fa59fb26b
Publikováno v:
BioTechniques, Vol 55, Iss 5, Pp 257-263 (2013)
We describe a series of new vectors for PCR-based epitope tagging and gene disruption in the fission yeast Schizosaccharomyces pombe, an exceptional model organism for the study of cellular processes. The vectors are designed for amplification of gen
Externí odkaz:
https://doaj.org/article/ef1e1bbdf353403e8da07d898a2a6019
Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress
Autor:
Oliver Limbo, Michael N. Boddy, Mariana C. Gadaleta, Minghua Nie, Martina Oravcová, Paul Russell, Michael C. Reubens
Publikováno v:
Molecular and Cellular Biology. 39
As genetic instability drives disease or loss of cell fitness, cellular safeguards have evolved to protect the genome, especially during sensitive cell cycle phases, such as DNA replication. Fission yeast Brc1 has emerged as a key factor in promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f9e5408cbc9fac36db51fcac5efdb5
https://doi.org/10.1128/mcb.00271-18
https://doi.org/10.1128/mcb.00271-18
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1007013 (2017)
PLoS Genetics
PLoS Genetics
The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5’-phosphate and 3’-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ab812cfc739b7071db1a9fefd9e106
http://europepmc.org/articles/PMC5626526?pdf=render
http://europepmc.org/articles/PMC5626526?pdf=render
The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5’-phosphate and 3’-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c228d4e3f9f6beb72a1f71212e9717ad
https://doi.org/10.1101/157354
https://doi.org/10.1101/157354
Autor:
Eishi Noguchi, Mariana C. Gadaleta
Publikováno v:
Genes, Vol 8, Iss 3, p 98 (2017)
Genes
Genes
All living organisms need to duplicate their genetic information while protecting it from unwanted mutations, which can lead to genetic disorders and cancer development. Inaccuracies during DNA replication are the major cause of genomic instability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0590d2c4b606bce33df428e093bf75
http://www.mdpi.com/2073-4425/8/3/98
http://www.mdpi.com/2073-4425/8/3/98
The DNA replication machinery encounters problems at numerous genomic regions that are inherently difficult to replicate. These genomic regions include telomeres, which contain repetitive DNA and telomere-binding proteins. If not properly regulated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1f2411f757e0e296a91c0ca722ed78
https://europepmc.org/articles/PMC5056121/
https://europepmc.org/articles/PMC5056121/
Autor:
Rocío Castilla, Mariana C. Gadaleta, Alejandra Duarte, Ernesto J. Podestá, Ana Fernanda Castillo, Fabiana Cornejo Maciel, Cristina Paz, Isabel Neuman
Publikováno v:
Endocrinology. 149:3743-3752
The studies presented herein were designed to investigate the effect of mouse epidermal growth factor (mEGF) on arachidonic acid (AA) release in a clonal strain of cultured murine Leydig cells (designed MA-10). In MA-10 cells, mEGF promotes AA releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8af73ed93a5797d4ad540f94a68f5e8
https://doi.org/10.1210/en.2007-1580
https://doi.org/10.1210/en.2007-1580
Publikováno v:
Methods in Molecular Biology ISBN: 9781493925957
DNA replication is tightly coupled with DNA repair processes in order to preserve genomic integrity. During DNA replication, the replication fork encounters a variety of obstacles including DNA damage/adducts, secondary structures, and programmed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f217bbc043a18599aa392266a8e70a9
https://doi.org/10.1007/978-1-4939-2596-4_12
https://doi.org/10.1007/978-1-4939-2596-4_12