Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mariana Boiani"'
Autor:
Fabiana Ross, Paola Hernández, Williams Porcal, Gloria V López, Hugo Cerecetto, Mercedes González, Tatiana Basika, Carlos Carmona, Martín Fló, Gabriela Maggioli, Mariana Bonilla, Vadim N Gladyshev, Mariana Boiani, Gustavo Salinas
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35033 (2012)
Parasitic flatworms are responsible for serious infectious diseases that affect humans as well as livestock animals in vast regions of the world. Yet, the drug armamentarium available for treatment of these infections is limited: praziquantel is the
Externí odkaz:
https://doaj.org/article/4b5c28b11d804cd8abeb5f1a5f3b8cb6
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
α-Aminocarbonyl metabolites (e.g., 5-aminolevulinic acid and aminoacetone) and the wide spectrum microbicide 1,4-diamino-2-butanone (DAB) have been shown to exhibit pro-oxidant properties. In vitro, these compounds undergo phosphate-catalyzed enoliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1ec9021a7f353e553a3e2db38dd208
https://doi.org/10.3109/10715762.2013.814126
https://doi.org/10.3109/10715762.2013.814126
Autor:
Joseph D. Manna, Ned A. Porter, Kristie L. Rose, Christopher D. Aluise, Lawrence J. Marnett, Michelle L. Reyzer, Keri A. Tallman, Mariana Boiani
Publikováno v:
Chemical Research in Toxicology
Oxidation of membrane phospholipids is associated with inflammation, neurodegenerative disease, and cancer. Oxyradical damage to phospholipids results in the production of reactive aldehydes that adduct proteins and modulate their function. 4-Hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b49de6c0588473cf9a02d0020f33eb
http://europepmc.org/articles/PMC3579456
http://europepmc.org/articles/PMC3579456
Autor:
Mercedes González, Lucía Boiani, Lucía Piacenza, Hugo Cerecetto, Ana Denicola, Mariana Boiani, Paola Hernández
Publikováno v:
Biochemical Pharmacology. 79:1736-1745
Chagas disease is caused by the trypanosomatid parasite Trypanosoma cruzi and threatens millions of lives in South America. As other neglected diseases there is almost no research and development effort by the pharmaceutical industry and the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37daa53566aaeec45d06cb8652dc8c98
https://doi.org/10.1016/j.bcp.2010.02.009
https://doi.org/10.1016/j.bcp.2010.02.009
Autor:
Mercedes González, Agustina Chidichimo, Alicia Merlino, Paola Hernández, Mariana Boiani, Juan José Cazzulo, Lucía Boiani, Hugo Cerecetto
Publikováno v:
European Journal of Medicinal Chemistry. 44:4426-4433
Exploring the influence of different substitution patterns of 2H-benzimidazole 1,3-dioxide derivatives (BzNO) we prepared fifteen new derivatives. Initially the BzNO were tested against Trypanosoma cruzi Tulahuen 2 strain epimastigote form rendering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250d63c275be55cf2c466f90ea04f2c0
https://doi.org/10.1016/j.ejmech.2009.06.014
https://doi.org/10.1016/j.ejmech.2009.06.014
Autor:
Alicia Merlino, Mariana Boiani, M.A. Rodríguez, Williams Porcal, Alejandra Gerpe, Hugo Cerecetto, Mercedes González, S. Depaula, Fiorela Croce
Publikováno v:
Xenobiotica. 39:236-248
The metabolism of six anti-Trypanosoma cruzi 5-phenylethenylbenzofuroxans (PhEBfx) was studied in vitro using rat hepatic microsomal and cytosolic fractions as a mammalian model and whole cells of T. cruzi as a parasitic model. Some of the expected m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f378e9f86d2edab7aa8d9d751dc741ce
https://doi.org/10.1080/00498250802691535
https://doi.org/10.1080/00498250802691535
Autor:
Mercedes González, Alejandra Gerpe, Alicia Merlino, Hugo Cerecetto, Williams Porcal, Mariana Boiani
Publikováno v:
Organic Process Research & Development. 12:156-162
In the present work, we developed robust processes for the preparation of new antitrypanosomal benzofuroxans, E and Z isomers of 5-arylethenylbenzo[1,2-c]1,2,5-oxadiazole N1-oxide 1–6, in multigram batch through Wittig−Boden conditions as the key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c02b75e4ed1faf6a34a90ab39bf7798
https://doi.org/10.1021/op7001722
https://doi.org/10.1021/op7001722
Autor:
Ana I. Gómez de Castro, Mercedes González, Gabriela Aguirre, Ana M. Ferreira, Lucía Boiani, Mariana Boiani, Alicia Merlino, Williams Porcal, Hugo Cerecetto, Rossanna Di Maio, Paola Hernández
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2768-2781
In vitro growth inhibitory activity of 21 new 5-ethenylbenzofuroxan derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, was studied. The designed compounds possess the previously described ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa707db83987a36396fb8499604ffea
https://doi.org/10.1016/j.bmc.2007.01.009
https://doi.org/10.1016/j.bmc.2007.01.009
Publikováno v:
The Journal of Physical Chemistry A. 108:11241-11248
The tautomeric forms of benzimidazole N-oxide derivatives in solution were studied using nuclear magnetic resonance (NMR) techniques. Further insight into the molecular structures was provided by t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4eb73ded8bb80a96c24499ad819eb9f
https://doi.org/10.1021/jp046826v
https://doi.org/10.1021/jp046826v
Autor:
Gabriela Aguirre, Alejandra Gerpe, Carmen Ochoa de Ocariz, Juan José Nogal, Yolanda Sainz, Hugo Cerecetto, Ana Denicola, David Montero, Mariana Boiani, Mercedes González, José Antonio Escario
Publikováno v:
Archiv der Pharmazie. 337:259-270
The syntheses and biological evaluation of the first anti-protozoa imidazole N-oxide and benzimidazole N-oxide and their derivatives are reported. They were tested in vitro against two different protozoa, Trypanosoma cruzi and Trichomonas vaginalis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4b333d671821de511f95fc548498a2
https://doi.org/10.1002/ardp.200300840
https://doi.org/10.1002/ardp.200300840