Výsledky vyhledávání - "Mariana Bleker de Oliveira"

Analytical Challenges in Development of Chemoresistance Predictors for Precision Oncology

Autor: Sergey N. Krylov, Vasilij Koshkin, Geoffrey Liu, Mariana Bleker de Oliveira

Publikováno v: Analytical Chemistry. 92:12101-12110

Chemoresistance, i.e., tumor insensitivity to chemotherapy, shortens life expectancy of cancer patients. Despite the availability of new treatment options, initial systemic regimens for solid tumors are dominated by a set of standard chemotherapy dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7269c6db49404055ad601a40d6d095
https://doi.org/10.1021/acs.analchem.0c02644

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Spheroid-Based Approach to Assess the Tissue Relevance of Analysis of Dispersed-Settled Tissue Cells by Cytometry of the Reaction Rate Constant

Autor: Mariana Bleker de Oliveira, Vasilij Koshkin, Sergey N. Krylov, Chun Peng, Allan Covens, Laurie Ailles, Geoffrey Liu

Publikováno v: Analytical Chemistry. 92:9348-9355

Cytometry of Reaction Rate Constant (CRRC) uses time-lapse fluorescence microscopy to measure a rate constant of a catalytic reaction in individual cells and, thus, facilitate accurate size determination for cell subpopulations with distinct efficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64edbfe6796ed64eb45e875547a63f2
https://doi.org/10.1021/acs.analchem.0c01667

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Stew in its Own Juice: Protein Homeostasis Machinery Inhibition Reduces Cell Viability in Multiple Myeloma Cell Lines

Autor: Angela Isabel Pereira Eugênio, Gisele W. B. Colleoni, Luiz Felipe G. Sanson, Mariana Bleker de Oliveira, Rebecca S S Barbosa-Dantas

Publikováno v: Current Molecular Medicine. 19:112-119

Introduction:Multiple myeloma (MM) cells accumulate in the bone marrow and produce enormous quantities of immunoglobulins, causing endoplasmatic reticulum stress and activation of protein handling machinery, such as heat shock protein response, autop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c681aaa6629d102f70ff9e70128434
https://doi.org/10.2174/1566524019666190305134441

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Multi-drug-resistance efflux in cisplatin-naive and cisplatin-exposed A2780 ovarian cancer cells responds differently to cell culture dimensionality

Autor: Geoffrey Liu, Mariana Bleker de Oliveira, Sergey N. Krylov, Laurie Ailles, Vasilij Koshkin, Chun Peng, Allan Covens

Publikováno v: Molecular and Clinical Oncology

A primary reason for chemotherapy failure is chemoresistance, which is driven by various mechanisms. Multi-drug resistance (MDR) is one such mechanism that is responsible for drug extrusion from the intracellular space. MDR can be intrinsic and thus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f906e4afa756652ece11a238db809a
http://europepmc.org/articles/PMC8273925

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Spheroid-Based Approach to Assess Tissue Relevance of Analysis of Dispersed-Settled Tissue Cells by Cytometry of Reaction Rate Constant

Autor: Sergey N. Krylov, Laurie Ailles, Geoffrey Liu, Mariana Bleker de Oliveira, Chun Peng, Allan Covens, Vasilij Koshkin

File main pdf file (CRRC of dispersed-settled spheroidal cells.pdf) describes experimental results and their interpretation for a study of tissue relevance of analyses of dispersed-settled tissues cells by Cytometry of Reaction Rate Constant (CRRC).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7e1f2d60c8ec3868e64fd10e1daa21
https://doi.org/10.26434/chemrxiv.12152016

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Transcriptome Analysis of Mesenchymal Stem Cells from Multiple Myeloma Patients Reveals Downregulation of Genes Involved in Cell Cycle Progression, Immune Response, and Bone Metabolism

Autor: Rodrigo Carlini Fernando, Veruska Lia Fook Alves, Edgar Gil Rizzatti, Hatylas Azevedo, Alex Freire Sandes, David Martins, Gisele W. B. Colleoni, Maria Aparecida Dalboni, Diego R. Mazzotti, Mariana Bleker de Oliveira, Fabricio de Carvalho, Angela Isabel Pereira Eugênio

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)

A growing body of evidence suggests a key role of tumor microenvironment, especially for bone marrow mesenchymal stem cells (MSC), in the maintenance and progression of multiple myeloma (MM), through direct and indirect interactions with tumor plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be725b542496b99e6c1656c34439937c
http://europepmc.org/articles/PMC6355867

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Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients

Autor: Faith E. Davies, Veruska L. Fook-Alves, Gisele W. B. Colleoni, Luiz Felipe G. Sanson, Mariana Bleker de Oliveira, Walter Moises Tobias Braga, Angela Isabel Pereira Eugênio, Mariana F. de Carvalho, Rodrigo Carlini Fernando

Publikováno v: Cancer letters. 403

JAK proteins have been linked with survival and proliferation of multiple myeloma (MM) cells; therefore, JAK inhibition could be a therapeutic strategy for MM. We evaluated JAK1 and JAK2 expression in MM patients and the effects of JAK/STAT pathway i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200552994404e01d120cad7eddc69b63
https://pubmed.ncbi.nlm.nih.gov/28645562

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Proteasome and heat shock protein 70 (HSP70) inhibitors as therapeutic alternative in multiple myeloma

Autor: Bryan E. Strauss, Marimelia Porcionatto, Rodrigo Carlini Fernando, Maria Regina Regis Silva, Gisele W. B. Colleoni, Veruska L. Fook-Alves, Daniela B Zanatta, Angela Isabel Pereira Eugênio, Mariana Bleker de Oliveira

Publikováno v: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
Oncotarget

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [2010/17668-6] HSP70 connects multiple signaling pathways that work synergistically to protect tumor ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc97854fbdb739cdedf7f6c0a6a3b15
https://repositorio.unifesp.br/handle/11600/53980

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TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1) stable silencing increases late apoptosis by upregulation of caspase 9 and APAF1 in RPMI8226 multiple myeloma cell line

Autor: Bryan E. Strauss, Veruska L. Fook-Alves, Mariana Bleker de Oliveira, Daniela B Zanatta, Gisele W. B. Colleoni

Publikováno v: Biochimica et biophysica acta. 1862(6)

Background TP53 Regulated Inhibitor of Apoptosis 1 ( TRIAP1 ) modulates apoptotic pathways preventing the formation of the apoptosome complex. Our group previous study showed that 90% of patients' multiple myeloma (MM) marrow-derived plasma cells pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df5fa062f9d41b0961f30d9532d4e94
https://pubmed.ncbi.nlm.nih.gov/27032384

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