ACE2, the Receptor that Enables Infection by SARS‐CoV‐2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators

Autor: Mariana Sacerdoti, Lissy Zoe Florens Gross, Stefan Zeuzem, Ricardo M. Biondi, Albrecht Piiper, Alejandro E. Leroux

Publikováno v: ChemMedChem
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Chemmedchem

Angiotensin Converting Enzyme 2 (ACE2) is the human receptor that interacts with the Spike protein of coronaviruses, including the one that produced the 2020 coronavirus pandemic (COVID-19). Thus, ACE2 is a potential target for drugs that disrupt the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8241b14a9662624e4ed2cc0e358befbe

Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling

Autor: Alejandro E, Leroux, Lissy Z F, Gross, Mariana, Sacerdoti, Ricardo M, Biondi

Publikováno v: Advances in experimental medicine and biology. 1163

Allostery is a basic principle that enables proteins to process and transmit cellular information. Protein kinases evolved allosteric mechanisms to transduce cellular signals to downstream signalling components or effector molecules. Protein kinases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbb583775d13e0d71ed9fe8341709712
https://pubmed.ncbi.nlm.nih.gov/31707708