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pro vyhledávání: '"Marian W. Kies"'
Autor:
Marian W. Kies
Publikováno v:
Annals of the New York Academy of Sciences. 122:161-170
Publikováno v:
Annals of the New York Academy of Sciences. 122:333-345
Publikováno v:
Journal of Neurochemistry. 47:1219-1225
Human myelin basic protein was subjected to ion-exchange chromatography at high pH to separate the differently charged components. Polyacrylamide gel electrophoretic patterns of the fractions showed that the less basic fractions 3, 4, and 5 contained
Autor:
Marian W. Kies
Publikováno v:
Annals of the New York Academy of Sciences. 122:242-244
Publikováno v:
Proteins: Structure, Function, and Genetics. 7:32-40
Controlled thrombic diges- tion of a preparation of components 2 + 3 iso- lated from the 18.5 kDa bovine myelin basic protein (MBP) yielded a polypeptide that was monophosphorylated on threonine 97 (compo- nent 3pT97). This is the first posttranslati
Publikováno v:
Cellular Immunology. 59:42-53
In vitro culture with myelin basic protein (BP) permits transfer of experimental allergic encephalomyelitis (EAE) with as few as 5 × 10 6 sensitized Lewis rat spleen cells. Activation of the sensitized cells is effective with as little as 0.1 μg/ml
Publikováno v:
The Journal of Immunology. 114:546-549
Strain 2 guinea pigs develop less severe experimental allergic encephalomyelitis than do strain 13 and Hartley guinea pigs when sensitized with equivalent amounts of homologous myelin basic protein (BP) in complete Freund's adjuvant. In vivo and in v
Publikováno v:
Neurochemical Pathology. 1:1-15
A method is described for the separation of two large peptic peptides of myelin basic protein (residue numbers, 1–88 and 89–169) by high performance liquid chromatography. These peptides had previously been purified by gel filtration and ion-exch
Publikováno v:
The Journal of Immunology. 112:392-397
Homologous myelin basic protein has been used successfully for treatment of experimental allergic encephalomyelitis (EAE) in NIH and strain 13 guinea pigs. Response of strain 13 guinea pigs to both induction and treatment of EAE was more consistent t
Publikováno v:
Annals of Neurology. 6:461-468
Autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (MS). Enough is now known about the cause, pathogenesis, and treatment of experimental allergic en