Výsledky vyhledávání - "Marian Llamas"

Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

Publikováno v: Nature medicine. 28(4)

Previous studies have suggested that the gut microbiome influences the response to checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial product that we postulated could augment CPI response through modulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3378fa6e57d09b2c6e662de7b7528b79
https://pubmed.ncbi.nlm.nih.gov/35899808

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Characterization of the microbial resistome in a prospective trial of CBM588 in metastatic renal cell carcinoma (mRCC) offers mechanism for interplay between antibiotic (abx) use and immune checkpoint inhibitor (ICI) activity

Publikováno v: Journal of Clinical Oncology. 40:4510-4510

4510 Background: The negative association between ICI response and abx therapy is well defined (Derosa et al Cancer Discov 2021). Paradoxically, a retrospective assessment of the live bacterial product (LBP) CBM588 in patients (pts) with advanced lun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f0771904670f00678d62f9350c108dc
https://doi.org/10.1200/jco.2022.40.16_suppl.4510

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Nivolumab/ipilimumab with or without CBM588 in metastatic renal cell carcinoma: A randomized phase Ib study and the evolution of the functionality of microbial communities with treatment

Autor: Nazli Dizman, Luis A Meza, Paulo Gustavo Bergerot, Marice Alcantara, Tanya B. Dorff, Yung Lyou, Paul Henry Frankel, Marian Llamas, Joann Hsu, Zeynep Busra Zengin, Jasnoor Malhotra, John D Gillece, Lauren J Reining, Jeffrey M. Trent, Motomichi Takahashi, Kentaro Oka, Seiya Higashi, Sarah K Highlander, Sumanta K. Pal

Publikováno v: Journal of Clinical Oncology. 40:371-371

371 Background: The role of gut microbial composition as a determinant of clinical outcomes has been well established in several cancers, including metastatic renal cell carcinoma (mRCC) (Routy et al Science 2018). A growing body of evidence suggests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7755311cb699124821280fdaef092991
https://doi.org/10.1200/jco.2022.40.6_suppl.371

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Intestinal microbiome associated with development of grade 3/4 adverse in patients with metastatic renal cell carcinoma (mRCC) treated with nivolumab plus ipilimumab (N/I) and probiotic support: Results from a phase Ib study

Publikováno v: Journal of Clinical Oncology. 40:374-374

374 Background: Treatment with N/I with the addition of CBM588, a live bacterial product comprised primarily of Clostridium butyricum, improved PFS and RR versus N/I alone when used as first line treatment for patients with mRCC (Meza et al ASCO 2021

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8093621735ceeb0c10b1dc254ae77174
https://doi.org/10.1200/jco.2022.40.6_suppl.374

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First results of a randomized phase IB study comparing nivolumab/ipilimumab with or without CBM-588 in patients with metastatic renal cell carcinoma

Publikováno v: Journal of Clinical Oncology. 39:4513-4513

4513 Background: Recent evidence suggests that the gut microbiome is a potent mediator of immune checkpoint inhibitor (ICI) activity in metastatic renal cell carcinoma (mRCC), with both specific bacterial species and cumulative microbial diversity dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32eb2e4d54854af8ba74175e2d0a5692
https://doi.org/10.1200/jco.2021.39.15_suppl.4513

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A WbpL mutant of Pseudomonas putida DOT-T1E strain, which lacks the O-antigenic side chain of lipopolysaccharides, is tolerant to organic solvent shocks

Autor: Juan L. Ramos, María Isabel Ramos-González, Frank Junker, Marian Llamas, Estrella Duque, Juan J. Rodriguez-Herva

Publikováno v: Extremophiles : life under extreme conditions. 5(2)

Lipopolysaccharides (LPS) are major components of the outer membrane of gram-negative bacteria and are considered a defense barrier. To determine if LPS play a role in resistance to solvents in the solvent-tolerant Pseudomonas putida DOT-T1E strain,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fcca60f18a34d8781e296a77726656
https://pubmed.ncbi.nlm.nih.gov/11354460

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