Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Marian J. Rewers"'
Autor:
Jake Lin, Elaheh Moradi, Karoliina Salenius, Suvi Lehtipuro, Tomi Häkkinen, Jutta E. Laiho, Sami Oikarinen, Sofia Randelin, Hemang M. Parikh, Jeffrey P. Krischer, Jorma Toppari, Åke Lernmark, Joseph F. Petrosino, Nadim J. Ajami, Jin-Xiong She, William A. Hagopian, Marian J. Rewers, Richard E. Lloyd, Kirsi J. Rautajoki, Heikki Hyöty, Matti Nykter, the TEDDY Study Group
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood t
Externí odkaz:
https://doaj.org/article/80ebd0159183481dafbd9063fd5905f9
Autor:
Bobbie-Jo M. Webb-Robertson, Ernesto S. Nakayasu, Fran Dong, Kathy C. Waugh, Javier E. Flores, Lisa M. Bramer, Athena A. Schepmoes, Yuqian Gao, Thomas L. Fillmore, Suna Onengut-Gumuscu, Ashley Frazer-Abel, Stephen S. Rich, V. Michael Holers, Thomas O. Metz, Marian J. Rewers
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108769- (2024)
Summary: Type 1 diabetes (T1D) is a chronic condition caused by autoimmune destruction of the insulin-producing pancreatic β cells. While it is known that gene-environment interactions play a key role in triggering the autoimmune process leading to
Externí odkaz:
https://doaj.org/article/acc4fc3a7d7e468abe5144f230ae4843
Autor:
Paul M. H. Tran, Fran Dong, Eileen Kim, Katherine P. Richardson, Lynn K. H. Tran, Kathleen Waugh, Diane Hopkins, Richard D. Cummings, Peng George Wang, Marian J. Rewers, Jin-Xiong She, Sharad Purohit
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Type I diabetes is characterized by autoantibodies directed against protein or non-protein self-antigens. Here the authors profile glycan reactive anti-carbohydrate antibodies (ACA) in a longitudinal and cross-sectional childhood diabetes cohort and
Externí odkaz:
https://doaj.org/article/cc29dd73dda34fbc8e8cebc84c5028fd
Autor:
Thomas A. Auchtung, Christopher J. Stewart, Daniel P. Smith, Eric W. Triplett, Daniel Agardh, William A. Hagopian, Anette G. Ziegler, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Åke Lernmark, Beena Akolkar, Jeffrey P. Krischer, Kendra Vehik, Jennifer M. Auchtung, Nadim J. Ajami, Joseph F. Petrosino
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Here, via metagenomics and ITS2 sequencing analysis of children's stool samples from three months to four years, the authors show that the fungal composition changes and relative abundance increases at weaning, but unlike bacteria, the overall levels
Externí odkaz:
https://doaj.org/article/a1e266bd6c4e4caaa8318335c7bc6aee
Autor:
Pooja Mehta, Qian Li, Marisa Stahl, Ulla Uusitalo, Katri Lindfors, Martha D Butterworth, Kalle Kurppa, Suvi Virtanen, Sibylle Koletzko, Carin Aronsson, William A Hagopian, Marian J Rewers, Jorma Toppari, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Daniel Agardh, Edwin Liu, TEDDY Study Group
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0275123 (2023)
BackgroundCeliac disease has an increasing incidence worldwide and is treated with lifelong adherence to a gluten-free diet. We aimed to describe gluten-free diet adherence rates in children with screening-identified celiac disease, determine adheren
Externí odkaz:
https://doaj.org/article/0f2d385020ad4b328d171cd17770ea91
Autor:
Angela M. Mitchell, Erin E. Baschal, Kristen A. McDaniel, Kimber M. Simmons, Laura Pyle, Kathleen Waugh, Andrea K. Steck, Liping Yu, Peter A. Gottlieb, Marian J. Rewers, Maki Nakayama, Aaron W. Michels
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
T cell receptor (TCR) sequences are exceptionally diverse and can now be comprehensively measured with next-generation sequencing technologies. However, a thorough investigation of longitudinal TCR repertoires throughout childhood in health and durin
Externí odkaz:
https://doaj.org/article/fdd60e79e23f4d1292274bdb7907007f
Autor:
Carin Andrén Aronsson, Xiang Liu, Jill M. Norris, Ulla Uusitalo, Martha D. Butterworth, Sibylle Koletzko, Suvi M. Virtanen, Iris Erlund, Kalle Kurppa, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Daniel Agardh
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Objectives: An observed variation in the risk of celiac disease, according to the season of birth, suggests that vitamin D may affect the development of the disease. The aim of this study was to investigate if vitamin D concentration is associated wi
Externí odkaz:
https://doaj.org/article/fb87afd0cc7949bcb14eb57ca9a3748e
Autor:
Jeffrey P, Krischer, Xiang, Liu, Åke, Lernmark, William A, Hagopian, Marian J, Rewers, Jin-Xiong, She, Jorma, Toppari, Anette-G, Ziegler, Beena, Akolkar, Eric, Triplett
Publikováno v:
Diabetes Care 45, 2271-2281 (2022)
OBJECTIVE To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. RESEARCH DESIGN AND METHODS Genetically high-risk newborns (n = 8,502) were fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d876e8bc663569389e1ed550d19c150
https://doi.org/10.2337/dc21-2612
https://doi.org/10.2337/dc21-2612
Autor:
Ingrid D. Santaren, Steven M. Watkins, Angela D. Liese, Lynne E. Wagenknecht, Marian J. Rewers, Steven M. Haffner, Carlos Lorenzo, Andreas Festa, Richard P. Bazinet, Anthony J. Hanley
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 11, Pp 2171-2179 (2017)
Recent evidence has documented distinct effects of individual saturated FAs (SFAs) on cardiometabolic outcomes, with potential protective effects from odd- and very long-chain SFAs (VLSFAs). Cross-sectional and prospective associations of individual
Externí odkaz:
https://doaj.org/article/a1d1cb75120a49e0b67fdcc64393e974
Autor:
Markus Lundgren, Leigh Johnson Steed, Roy Tamura, Berglind Jonsdottir, Patricia Gesualdo, Claire Crouch, Maija Sjöberg, Gertie Hansson, William A. Hagopian, Anette G. Ziegler, Marian J. Rewers, Åke Lernmark, Jorma Toppari, Jin-Xiong She, Beena Akolkar, Jeffrey P. Krischer, Michael J. Haller, Helena Elding Larsson, for the TEDDY Study Group
Publikováno v:
BMC Pediatrics, Vol 17, Iss 1, Pp 1-9 (2017)
Abstract Background The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeos
Externí odkaz:
https://doaj.org/article/7b36d4244b554cf29d222bc64a920671