Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marian H. Hettiaratchi"'
Autor:
Satoshi Nori, Mohamad Khazaei, Christopher S. Ahuja, Kazuya Yokota, Jan-Eric Ahlfors, Yang Liu, Jian Wang, Shinsuke Shibata, Jonathon Chio, Marian H. Hettiaratchi, Tobias Führmann, Molly S. Shoichet, Michael G. Fehlings
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1433-1448 (2018)
Summary: Treatment of chronic spinal cord injury (SCI) is challenging due to cell loss, cyst formation, and the glial scar. Previously, we reported on the therapeutic potential of a neural progenitor cell (NPC) and chondroitinase ABC (ChABC) combinat
Externí odkaz:
https://doaj.org/article/7a1ee5dff6e0435aad60f21cfb9900c3
Autor:
Marian H. Hettiaratchi, Alex Schudel, Tel Rouse, Andrés J. García, Susan N. Thomas, Robert E. Guldberg, Todd C. McDevitt
Publikováno v:
APL Bioengineering, Vol 2, Iss 2, Pp 026110-026110-14 (2018)
Hydrogels present versatile platforms for the encapsulation and delivery of proteins and cells for regenerative medicine applications. However, differences in hydrogel cross-linking density, polymer weight content, and affinity for proteins all contr
Externí odkaz:
https://doaj.org/article/d0edaaf9af8045b7b3f2e4ee7cb39709
Publikováno v:
Free Radic Biol Med
Reactive oxygen species (ROS) are important modulators of physiological signaling and play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and reactive selenium species (RSeS) are involved in ROS signaling, and recent wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a277494d5ed68a30f832ebb678cb5e
https://doi.org/10.1016/j.freeradbiomed.2022.08.002
https://doi.org/10.1016/j.freeradbiomed.2022.08.002
Autor:
Robert E. Guldberg, Andrés J. García, Nick J. Willett, Ramesh Subbiah, Luiz E. Bertassoni, Marissa A. Ruehle, Brett S. Klosterhoff, Angela S.P. Lin, Marian H. Hettiaratchi
Publikováno v:
Acta Biomaterialia. 127:180-192
Successful bone healing in severe trauma depends on early revascularization to restore oxygen, nutrient, growth factor, and progenitor cell supply to the injury. Therapeutic angiogenesis strategies have therefore been investigated to promote revascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5071108a8f99984c0f18ae6e8b4647
https://doi.org/10.1016/j.actbio.2021.03.066
https://doi.org/10.1016/j.actbio.2021.03.066
Publikováno v:
Biomaterials Science. 9:2339-2361
Tissue repair requires a complex cascade of events mediated by a variety of cells, proteins, and matrix molecules; however, the healing cascade can be easily disrupted by numerous factors, resulting in impaired tissue regeneration. Recent advances in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a324bc565ee847205ebb67965c510748
https://doi.org/10.1039/d0bm01804j
https://doi.org/10.1039/d0bm01804j
Autor:
Andrew J. Pickering, Tove Kivijärvi, Marian H. Hettiaratchi, Vianney Delplace, Molly S. Shoichet, Spencer Zhao
Publikováno v:
Biomacromolecules. 21:2421-2431
A hydrogel that can deliver both proteins and cells enables the local microenvironment of transplanted cells to be manipulated with a single injection. Toward this goal, we designed a hydrogel suitable for the co-delivery of neural stem cells and cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ba1b797fbdd0338abba0c0ba2e89fe
https://doi.org/10.1021/acs.biomac.0c00357
https://doi.org/10.1021/acs.biomac.0c00357
Autor:
Lauren B. Priddy, Laxminarayanan Krishnan, Marian H. Hettiaratchi, Sukhita Karthikeyakannan, Nikhil Gupte, Robert E. Guldberg
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 41(1)
Treatment of large bone defects with supraphysiological doses of bone morphogenetic protein-2 (BMP-2) has been associated with complications including heterotopic ossification (HO), inflammation, and pain, presumably due to poor spatiotemporal contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ac81e462a53e22bdcba8c5ee4fd382
https://pubmed.ncbi.nlm.nih.gov/35340049
https://pubmed.ncbi.nlm.nih.gov/35340049
Autor:
Matthew J. O’Meara, Teresa R. O’Meara, Molly S. Shoichet, Marian H. Hettiaratchi, Andrew J. Pickering, Nitzan Letko-Khait
Publikováno v:
Science Advances
Computational redesign of chondroitinase ABC introduces 37 point mutations to improve enzyme stability and activity.
Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC (ChABC) has shown promise in central
Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC (ChABC) has shown promise in central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90232643a81f2e45688cae40b1ec3944
https://doi.org/10.1126/sciadv.abc6378
https://doi.org/10.1126/sciadv.abc6378
Autor:
Luiz E. Bertassoni, Robert E. Guldberg, Marian H. Hettiaratchi, Marissa A. Ruehle, Albert Cheng, Ramesh Subbiah
Publikováno v:
Acta biomaterialia. 114
The objective of this study was to investigate the controlled release of two growth factors (BMP-2 and VEGF) as a treatment strategy for clinically challenging composite injuries, consisting of a segmental bone defect and volumetric muscle loss. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15079c8d72ab671b5239e06503eebc67
https://pubmed.ncbi.nlm.nih.gov/32688092
https://pubmed.ncbi.nlm.nih.gov/32688092
Autor:
Laxminarayanan Krishnan, Tel Rouse, Catherine Chou, Marian H. Hettiaratchi, Todd C. McDevitt, Robert E. Guldberg
Publikováno v:
Science advances, vol 6, iss 1
Science Advances
Science Advances
Heparin-based microparticles improve spatial localization of BMP-2 delivery, decreasing bone formation outside of the injury site.
Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fr
Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e24c61b7492b9fa9a95b44a88d0a5f
https://escholarship.org/uc/item/9j31d405
https://escholarship.org/uc/item/9j31d405
