Výsledky vyhledávání - "Marian G. Young"

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Autor: Marian G. Young, Dario Fiore, Peter C. Rahn, Gary H. Reitnauer, Stephen Michalczyk, Harold N. Weller, Steven J. Fischman, Robert S. Cooley, Dana J. Loyd

Publikováno v: Molecular Diversity. 3:61-70

Rapid reverse-phase analytical and preparative HPLC methods havebeen developed for application to parallel synthesis libraries.Gradient methods, short columns, and high flow rates allowanalysis of over 300 compounds per day on a single system, orpuri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e52916b1047400b6eb74bb06d00360d
https://doi.org/10.1023/a:1009636725336

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Hydroxamic acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase

Autor: Eric M. Gordon, Dinesh V. Patel, Simon P. Robinson, Lisa Hunihan, Brenda J. Dean, Marian G. Young

Publikováno v: Journal of medicinal chemistry. 39(21)

The rational design, synthesis, and activity of novel, hydroxamic acid-based, collective bisubstrate analog inhibitors of farnesyl protein transferase (FPT) is described. This class of compounds differ structurally from the conventional FPT inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07665e6ab95250ff3b54cddd300852e5
https://pubmed.ncbi.nlm.nih.gov/8863797

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Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase

Autor: Dinesh V. Patel, Eric M. Gordon, Robert J. Schmidt, Harold N. Weller, Marian G. Young, Robert Zahler, Mariano Barbacid, Joan M. Carboni, Johnni L. Gullo-Brown, Lisa Hunihan, Carol Ricca, Simon Robinson, Bernd R. Seizinger, Anne V. Tuomari, Veeraswamy Manne

Publikováno v: Journal of medicinal chemistry. 38(3)

The rational design, synthesis, and biological activity of phosphonyl- and phosphinyl-linked bisubstrate analog inhibitors of the enzyme Ras farnesyl protein transferase (FPT) are described. The design strategy for these bisubstrate inhibitors involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91835b967fd962ba3adaa99a90eb8912
https://pubmed.ncbi.nlm.nih.gov/7853336

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Analysis of diastereomeric 7-ureidoacetamido cephalosporins by high-performance liquid chromatography

Autor: Marian G. Young

Publikováno v: Journal of Chromatography A. 150:221-224

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f82767e48d2c2c2b0d19918cbf240d8d
https://doi.org/10.1016/s0021-9673(01)92118-1

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Diastereomeric 7-ureidoacetyl cephalosporins. I. Superiority of 7.ALPHA.-H-L-isomers over D-isomers

Autor: Marian G. Young, Treuner Uwe D, Hermann Breuer, H. I. Basch, H. J. Schneider

Publikováno v: The Journal of Antibiotics. 31:546-560

The synthesis and in vitro structure-activity relationship of 7-ureidoacetyl cephalosporins carrying various substituents in the 3-position, compounds that showed an enhanced broad spectrum of antibacterial activity, has been outlined. Contrary to mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7801507fedf2d5faf34fe6a2c7815e41
https://doi.org/10.7164/antibiotics.31.546

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Bacterial production of 7-formamidocephalosporins. Isolation and structure determination

Autor: Richard B. Sykes, Marian G. Young, Janice H. Johnson, Pushpa D. Singh, Christopher M. Cimarusti

Publikováno v: The Journal of antibiotics. 37(7)

Two new 7-formamidocephalosporins have been isolated as their acetyl derivatives (SQ 28, 516 and SQ 28, 517) from fermentations of a Flavobacterium sp. SC 12, 154. Structure 1 was deduced for SQ 28, 516 from its spectroscopic properties while structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4480767e45a06b2e2d95216f7e6b39
https://pubmed.ncbi.nlm.nih.gov/6547947

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