Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Marian E Gindy"'
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
Autor:
Zhu Chen, Bin Luo, Tian-Quan Cai, Anil Thankappan, Yiming Xu, Weizhen Wu, Jillian DiMuzio, Traci Lifsted, Marty DiPietro, Jyoti Disa, Bruce Ng, Karen Leander, Seth Clark, Lizbeth Hoos, Yuchen Zhou, Nina Jochnowitz, Christine Jachec, Peter Szczerba, Marian E Gindy, Walter Strapps, Laura Sepp-Lorenzino, Dietmar A Seiffert, Laura Lubbers, Marija Tadin-Strapps
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA
Externí odkaz:
https://doaj.org/article/da51b10ff9c64e0ebedcb655dbab5e3c
Autor:
Lauren A. Austin, Jeffrey S. Smith, Debbie D. Nahas, Andrew Danzinger, Susan Secore, Gregory O’Donnell, Scott Radcliffe, Shuai Hu, Jeffrey Perley, Andrew J. Bett, Marian E. Gindy
Publikováno v:
Molecular Pharmaceutics. 20:279-289
mRNA vaccines have recently received significant attention due to their role in combating the SARS-CoV-2 pandemic. As a platform, mRNA vaccines have been shown to elicit strong humoral and cellular immune responses with acceptable safety profiles for
Autor:
Mingyue Li, Bradley T. Falk, Xingyu Lu, Ryan Schroder, Mark Mccoy, Wei Xu, Daniel H. Yin, Marian E. Gindy, Suzanne M. D’Addio, Yongchao Su
Publikováno v:
Molecular Pharmaceutics. 19:3267-3278
Antimicrobial preservatives are used as functional excipients in multidose formulations of biological therapeutics to destroy or inhibit the growth of microbial contaminants, which may be introduced by repeatedly administering doses. Antimicrobial ag
Autor:
Jessica A, Flynn, Teresa, Weber, Pedro J, Cejas, Kara S, Cox, Sinoeun, Touch, Lauren A, Austin, Yangsi, Ou, Michael P, Citron, Bin, Luo, Marian E, Gindy, Kapil, Bahl, Giuseppe, Ciaramella, Amy S, Espeseth, Lan, Zhang
Publikováno v:
Vaccine. 40:4412-4423
In response to immune pressure, influenza viruses evolve, producing drifted variants capable of escaping immune recognition. One strategy for inducing a broad-spectrum immune response capable of recognizing multiple antigenically diverse strains is t
Publikováno v:
Journal of Pharmaceutical Sciences. 110:850-859
New classes of therapeutic peptides are being developed to prosecute biological targets which have been inaccessible to other modalities. Higher potency and longer half-life peptides have given rise to multiuse injectable formulations that enable con
Autor:
Fengsheng Li, Morgan A. Monslow, Amy S. Espeseth, Kalpit A. Vora, Dai Wang, Dan Chang, Tong-Ming Fu, Marian E. Gindy, Daniel C. Freed, Nikolai Petrovsky, Hualin Li
Publikováno v:
Vaccine. 39(51)
Adjuvants have long been explored to enhance vaccine efficacy. Current adjuvants approved for human vaccines are mostly studied for their ability to improve antibody responses. There remains a need for development of novel adjuvants, especially those
Autor:
Andrew J. Bett, Dai Wang, Zhiyun Wen, Andrew H. Latham, Lan Zhang, Kalpit A. Vora, Michael P. Citron, Jeffrey S. Smith, Marian E. Gindy, Christine A. Shaw, Joseph M. Antonello, Jessica A. Flynn, Ryan Swoyer, Cheryl Callahan, Giuseppe Ciaramella, Paloma Cejas, Daniel J. DiStefano, Kapil Bahl, Daniel C. Freed, Kara S. Cox, Gregory O’ Donnell, Amy S. Espeseth, Sinoeun Touch, Jennifer D. Galli, Daria J. Hazuda
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 5, Iss 1, Pp 1-14 (2020)
npj Vaccines, Vol 5, Iss 1, Pp 1-14 (2020)
The RSV Fusion (F) protein is a target for neutralizing antibody responses and is a focus for vaccine discovery; however, the process of RSV entry requires F to adopt a metastable prefusion form and transition to a more stable postfusion form, which
Autor:
Jianzhong Wen, Nicole Buist, Ying Li, Scott Fauty, Prajakta Gadgil, Marian E. Gindy, Alexei V. Buevich, Tomi K. Sawyer, Candice Alleyne, Mengwei Hu, Kung-I Feng, Gino Salituro, Rebecca Nofsinger
Publikováno v:
Pharmaceutical Research. 36
In this study we evaluated the utility of in-vitro screening tools for predicting the in-vivo behavior of six cyclic peptides with different solubility and permeability properties (BCS class II and III), intended for oral delivery in presence of perm
Autor:
Megan A. Mackey, Takayuki Tsuchiya, Marian E. Gindy, Steven J. Henry, Li Li, Zhen Yang, Gregory J. Doto, Ryan S. Teller, Lee J. Klein, Stephanie E. Barrett, Michael P. Ruth, Seth P. Forster
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 136
Alternative formulations of entecavir, a once daily oral hepatitis B antiretroviral, may improve treatment adherence by patients. We explored the use of biocompatible polymers to control entecavir dissolution in two formats suitable for subcutaneous
Autor:
Amy S. Espeseth, Benjamin D. Brooks, Harvey M. Friedman, Noah Ditto, Gokul Swaminathan, Jeffrey S. Smith, Tina M. Cairns, Andrew J. Bett, Lauren M. Hook, Gary H. Cohen, Sita Awasthi, Marian E. Gindy
Publikováno v:
Vaccine
We are interested in developing a vaccine that prevents genital herpes. Adjuvants have a major impact on vaccine immunogenicity. We compared two adjuvants, an experimental Merck Sharp & Dohme lipid nanoparticle (LNP) adjuvant, LNP-2, with CpG oligonu