Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Marian Ludgate"'
Autor:
Mohd Shazli Draman, Fiona Grennan-Jones, Peter Taylor, Ilaria Muller, Sam Evans, Anjana Haridas, Daniel S. Morris, D. Aled Rees, Carol Lane, Colin Dayan, Lei Zhang, Marian Ludgate
Publikováno v:
Current Issues in Molecular Biology, Vol 43, Iss 3, Pp 1794-1804 (2021)
Thyroid stimulating antibodies (TSAB) cause Graves’ disease and contribute to Graves’ Orbitopathy (GO) pathogenesis. We hypothesise that the presence of TSH binding proteins (truncated TSHR variants (TSHRv)) and/or nonclassical ligands such as th
Externí odkaz:
https://doaj.org/article/51b8990d34914620a6eea41a39459725
Autor:
Sajad Moshkelgosha, Hedda Luise Verhasselt, Giulia Masetti, Danila Covelli, Filippo Biscarini, Mareike Horstmann, Anke Daser, Astrid M. Westendorf, Christoph Jesenek, Svenja Philipp, Salvador Diaz-Cano, J. Paul Banga, Daryn Michael, Sue Plummer, Julian R. Marchesi, Anja Eckstein, Marian Ludgate, Utta Berchner-Pfannschmidt, and the INDIGO consortium
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Background Graves’ disease (GD) is an autoimmune condition in which autoantibodies to the thyrotropin receptor (TSHR) cause hyperthyroidism. About 50% of GD patients also have Graves’ orbitopathy (GO), an intractable disease in which exp
Externí odkaz:
https://doaj.org/article/4d003daeb4e049e9aa64bd3dd0270407
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/e07022495f2a4edc8e97fe5c5f6896eb
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Graves’ orbitopathy (GO) is a complex and poorly understood disease in which extensive remodeling of orbital tissue is dominated by adipogenesis and hyaluronan production. The resulting proptosis is disfiguring and underpins the majority of GO sign
Externí odkaz:
https://doaj.org/article/0456f4bc26fe4bcebabc3b17081127c1
Autor:
Giulia Masetti, Sajad Moshkelgosha, Hedda-Luise Köhling, Danila Covelli, Jasvinder Paul Banga, Utta Berchner-Pfannschmidt, Mareike Horstmann, Salvador Diaz-Cano, Gina-Eva Goertz, Sue Plummer, Anja Eckstein, Marian Ludgate, Filippo Biscarini, Julian Roberto Marchesi, the INDIGO consortium
Publikováno v:
Microbiome, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background Variation in induced models of autoimmunity has been attributed to the housing environment and its effect on the gut microbiota. In Graves’ disease (GD), autoantibodies to the thyrotropin receptor (TSHR) cause autoimmune hyperth
Externí odkaz:
https://doaj.org/article/5c989b25ca984a3dac9fe189f5e70b89
Autor:
Filippo Biscarini, Giulia Masetti, Ilaria Muller, Hedda Luise Verhasselt, Danila Covelli, Giuseppe Colucci, Lei Zhang, Mohd Shazli Draman, Onyebuchi Okosieme, Pete Taylor, Chantal Daumerie, Maria-Cristina Burlacu, Michele Marinò, Daniel George Ezra, Petros Perros, Sue Plummer, Anja Eckstein, Mario Salvi, Julian R Marchesi, Marian Ludgate
Publikováno v:
The Journal of clinical endocrinology and metabolism, (2023)
Context Gut bacteria can influence host immune responses but little is known about their role in tolerance-loss mechanisms in Graves disease (GD; hyperthyroidism caused by autoantibodies, TRAb, to the thyrotropin receptor, TSHR) and its progression t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41b017f263d98ed4bfbf833867a3185
https://hdl.handle.net/2078.1/273521
https://hdl.handle.net/2078.1/273521
Autor:
Katherine D. Connolly, Irina A. Guschina, Vincent Yeung, Aled Clayton, Mohd Shazli Draman, Christopher Von Ruhland, Marian Ludgate, Philip E. James, D. Aled Rees
Publikováno v:
Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-10 (2015)
Extracellular vesicles (EVs) are submicron vesicles released from many cell types, including adipocytes. EVs are implicated in the pathogenesis of obesity-driven cardiovascular disease, although the characteristics of adipocyte-derived EVs are not we
Externí odkaz:
https://doaj.org/article/e468ee08762145279c5615e897b9b2df
Context: Gut bacteria can influence host immune responses but little is known about their role in tolerance-loss mechanisms in Graves’ disease (GD; hyperthyroidism caused by autoantibodies, TRAB, to the thyrotropin receptor, TSHR) and its progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a7e1d424e2df6e1a71fc27a9ae6bcd
Autor:
John Gregory, Toby Candler, Dionne Shillabeer, Marian Ludgate, Ilaria Muller, Rhian Daniel, John Lazarus, Rebecca J. Pettit, D. Aled Rees, Charlotte Hales, William D. Evans, Mohd Shazli Draman, Anna Scholz, Colin M. Dayan, Peter N. Taylor, Onyebuchi E. Okosieme, Hiu K C Tang
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:2150-2161
Context and Objectives The Controlled Antenatal Thyroid Screening Study I (CATS-I) was a randomized controlled trial investigating the effects of levothyroxine therapy for suboptimal gestational thyroid function (SGTF), comparing outcomes in children
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ed619d16a01640cc2044819576a4d2
https://doi.org/10.1210/clinem/dgaa129
https://doi.org/10.1210/clinem/dgaa129
Autor:
Andrew R. Tee, Pavandeep K. Rai, Douglass M. Turnbull, Mohd Shazli Draman, Colin M. Dayan, Lei Zhang, Marian Ludgate, D. Aled Rees, Satomi Miwa, Daniel S Morris, Anjana S Haridas
Context Depot-specific expansion of orbital adipose tissue (OAT) in Graves orbitopathy (GO; an autoimmune condition producing proptosis, visual impairment and reduced quality of life) is associated with fatty acid (FA)-uptake–driven adipogenesis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d17d1ca9f92e5bf145d5296d378ec8