ATP-P2X7R pathway activation limits the Tfh cell compartment during pediatric RSV infection

Autor: Constanza Russo, Silvina Raiden, Silvia Algieri, María José Bruera, Norberto De Carli, Mariam Sarli, Héctor Cairoli, Leonardo De Lillo, Ivanna Morales, Vanesa Seery, Adrián Otero, Inés Sananez, Nancy Simaz, Gisela Alfiero, Gabriela Rubino, Néstor Moya, Luisa Aedo Portela, Mauro Herrero, Marina Blanco, Misael Salcedo Pereira, Fernando Ferrero, Jorge Geffner, Lourdes Arruvito

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundFollicular helper T cells (Tfh) are pivotal in B cell responses. Activation of the purinergic receptor P2X7 on Tfh cells regulates their activity. We investigated the ATP-P2X7R axis in circulating Tfh (cTfh) cells during Respiratory Syncyti

Externí odkaz: https://doaj.org/article/5cb3f5e2e20b47ababa9e46cab835463

A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children

Autor: Inés Sananez, Silvina C. Raiden, Silvia C. Algieri, Macarena Uranga, Nicolás A. Grisolía, Daniela Filippo, Norberto De Carli, Sandra Di Lalla, Héctor Cairoli, María J. Chiolo, Claudia N. Meregalli, Emilia Cohen, Graciela Mosquera, María Marcó del Pont, Lorena I. Giménez, Gabriela Gregorio, Mariam Sarli, Ana L. Alcalde, Carolina Davenport, María J. Bruera, Nancy Simaz, Mariela F. Pérez, Valeria Nivela, Carola Bayle, Laura Alvarez, María Revetria, Patricia Tuccillo, María T. Agosta, Hernán Pérez, Susana Villa Nova, Patricia Suárez, Eugenia M. Takata, Mariela García, Jorge Lattner, María J. Rolón, Patricia Coll, Melina Salvatori, Claudio Piccardo, Constanza Russo, Augusto Varese, Vanesa Seery, María P. Holgado, María L. Polo, Ana Ceballos, Myriam Nuñez, Juan Martín Gómez Penedo, Fernando Ferrero, Jorge Geffner, Lourdes Arruvito

Publikováno v: EBioMedicine, Vol 72, Iss , Pp 103615- (2021)

Background: Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19)

Externí odkaz: https://doaj.org/article/274c63d0dd3d4687b8b8ce1e7c248858

A Poor and Delayed Anti-SARS-CoV2 IgG Response is Associated to Severe COVID-19 in Children

Autor: Graciela Mosquera, Gabriela Gregorio, Maria Laura Polo, Claudia Meregalli, Laura Alvarez, Mariela García, María Marcó del Pont, María J. Chiolo, Susana Villa Nova, Maria Luisa Rolon, Inés Sananez, Macarena Uranga, Lourdes Arruvito, Patricia Tuccillo, Nicolás A. Grisolía, Jorge Lattner, Daniela Filippo, María Revetria, Melina Salvatori, Patricia Suárez, Silvia C. Algieri, María Pía Holgado, Ana L. Alcalde, Mariela F. Pérez, Valeria Nivela, Ana Ceballosa, María Temis Agosta, Patricia Coll, H. Cairoli, Eugenia M. Takata, María J. Bruera, Vanesa Seery, Nancy Simaz, Emilia Cohen, Carola Bayle, Fernando Ferrero, Sandra Di Lalla, Mariam Sarli, Jorge Geffner, Constanza Russo, Lorena I. Gimenez, Norberto De Carli, Hernán Pérez, Augusto Varese, Silvina Raiden, Claudio Piccardo, Carolina Davenport

Publikováno v: SSRN Electronic Journal.

Background: Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60742cd433e73c4c850be410ea55e2b3
https://doi.org/10.2139/ssrn.3857602

Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers

Autor: Lorena I. Gimenez, Claudia Meregalli, Norberto De Carli, María J. Chiolo, Susana Villa Nova, Mariela García, María P. Holgado, Jorge Lattner, María José Rolón, Hernán Pérez, Silvia C. Algieri, Nicolás A. Grisolía, Eugenia M. Takata, Mariam Sarli, María J. Bruera, Mariela F. Pérez, Valeria Nivela, Sandra Di Lalla, Patricia G Suárez, Silvina Raiden, Nancy Simaz, Patricia Tuccillo, Carola Bayle, Fernando Ferrero, Inés Sananez, Jorge Geffner, Daniela Filippo, Ana L. Alcalde, Carolina Davenport, María Temis Agosta, Patricia Coll, Vanesa Seery, Gabriela Gregorio, Lourdes Arruvito, Héctor Cairoli

Publikováno v: EBioMedicine
EBioMedicine, Vol 67, Iss, Pp 103357-(2021)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background: Perhaps reflecting that children with COVID-19 rarely exhibit severe respiratory symptoms and often remain asymptomatic, little attention has been paid to explore the immune response in pediatric COVID-19. Here, we analyzed the phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35dcc626b3df6bdb7dd9ed5b8ca735c1
http://europepmc.org/articles/PMC8153212

[Pediatric emergency medicine specialty: Welcome!]

Autor: Guillermo, Kohn Loncarica, Daniel, Buamscha, Guillermo, Fagalde, Tomás, Iolster, Facundo, Jorro, Guillermo, Moreno, Pablo, Petracca, Silvia, Santos, Mariam, Sarli

Publikováno v: Archivos argentinos de pediatria. 116(4)

Pediatric Emergency Medicine has developed around the world as a subspecialty of pediatrics. There is plenty of data reflecting a growing need for its services. The subspecialty was initiated in the United States and Argentina, together with other La

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08696d206d788c8f7786c59b755f8d3f
https://pubmed.ncbi.nlm.nih.gov/30016049