Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mariam M. Mahmoud"'
Autor:
Joann B. Sweasy, Rebecca Kaup, Johannes Hohlbein, Jamie B. Towle-Weicksel, Meike Kronenberg, Mattia Fontana, Carel Fijen, Mariam M. Mahmoud
Publikováno v:
The Journal of biological chemistry 295 (2020) 27
J Biol Chem
The Journal of biological chemistry, 295(27), 9012-9020
J Biol Chem
The Journal of biological chemistry, 295(27), 9012-9020
Eukaryotic DNA polymerase β (Pol β) plays an important role in cellular DNA repair, as it fills short gaps in dsDNA that result from removal of damaged bases. Since defects in DNA repair may lead to cancer and genetic instabilities, Pol β has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2e7524b9d847e25f0679ac44d79089
https://doi.org/10.1074/jbc.ra120.013049
https://doi.org/10.1074/jbc.ra120.013049
Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells
Autor:
Yu Shyr, Yong Kong, Shuangge Ma, Hailey Wyatt, Kaylyn Clairmont, Victoria Quintana, Shilin Zhao, Kurt A. Schalper, Zachary D. Nagel, Rithy Meas, Patricia LoRusso, Sebastian Oeck, Isabel Alvarado-Cruz, Angelo Porciuncula, Ying Zhu, Daniel J. Laverty, Michael Krauthammer, Mariam M. Mahmoud, Joann B. Sweasy, Mohammed Khan
Publikováno v:
Biochem Pharmacol
Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors (PARPi) have been suggested to act by either catalytic inhibition or by PARP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be385c651532db58837877fc5a7fae6
https://www.ncbi.nlm.nih.gov/pubmed/33285109
https://www.ncbi.nlm.nih.gov/pubmed/33285109
Autor:
Rithy Meas, Daniel J. Laverty, Kaylyn Clairmont, Victoria Quintana, Isabel Alvarado-Cruz, Patricia LoRusso, Sebastian Oeck, Hailey Wyatt, Kurt A. Schalper, Mariam M. Mahmoud, Angelo Porciuncula, Ying Zhu, Joann B. Sweasy, Mohammed Khan, Yu Shyr, Yong Kong, Zachary D. Nagel, Shuangge Ma, Shilin Zhao, Michael Krauthammer
Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors have been suggested to act by either catalytic inhibition or by PARP localiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b249682be3db497cd9f36a1bfda2780
https://doi.org/10.1101/2020.03.08.982785
https://doi.org/10.1101/2020.03.08.982785
Autor:
Sylvie Doublié, Khadijeh S. Alnajjar, Brian E. Eckenroth, Mariam M. Mahmoud, Joann B. Sweasy, Ji Huang
Publikováno v:
Journal of Biological Chemistry. 293:15084-15094
DNA polymerase β (Pol β) is essential for maintaining genomic integrity. During short-patch base excision repair (BER), Pol β incorporates a nucleotide into a single-gapped DNA substrate. Pol β may also function in long-patch BER, where the DNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9a6af8c4043249daabbb06d350671c
https://doi.org/10.1074/jbc.ra118.004564
https://doi.org/10.1074/jbc.ra118.004564
Autor:
Sylvie Doublié, Khadijeh S. Alnajjar, J.P. Loria, Joann B. Sweasy, K. East, Jamie B. Towle-Weicksel, C. Liptak, Brian E. Eckenroth, Mariam M. Mahmoud, M.V. Moreno, Jun Huang
Publikováno v:
Nucleic Acids Research
DNA polymerase β (pol β) fills single nucleotide gaps in DNA during base excision repair and non-homologous end-joining. Pol β must select the correct nucleotide from among a pool of four nucleotides with similar structures and properties in order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52164d62b85902a9d011f445516c924
http://europepmc.org/articles/PMC6237750
http://europepmc.org/articles/PMC6237750
Autor:
Jamie B. Towle-Weicksel, Sylvie Doublié, Mariam M. Mahmoud, Allison N. Schechter, Joann B. Sweasy, Ji Huang, Brian E. Eckenroth, Khadijeh S. Alnajjar
Publikováno v:
Biochemistry. 56:5550-5559
DNA polymerases synthesize new DNA during DNA replication and repair, and their ability to do so faithfully is essential to maintaining genomic integrity. DNA polymerase β (Pol β) functions in base excision repair to fill in single-nucleotide gaps,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360bd0fd03488989867ca91bd52701c7
https://doi.org/10.1021/acs.biochem.7b00869
https://doi.org/10.1021/acs.biochem.7b00869
Autor:
Pouya Haratipour, Boris A. Kashemirov, Joann B. Sweasy, Myron F. Goodman, Ivan S. Krylov, Charles E. McKenna, Mariam M. Mahmoud, Ji Huang, Amirsoheil Negahbani, Khadijeh S. Alnajjar
Publikováno v:
Nucleic Acids Research
DNA polymerase β (pol β) selects the correct deoxyribonucleoside triphosphate for incorporation into the DNA polymer. Mistakes made by pol β lead to mutations, some of which occur within specific sequence contexts to generate mutation hotspots. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ef801ebab61335ca59bf39c4c7c701
https://pubmed.ncbi.nlm.nih.gov/31732732
https://pubmed.ncbi.nlm.nih.gov/31732732
Autor:
Patricia H. Reggio, Hui Liu, Debra A. Kendall, Dow P. Hurst, Dai Lu, Derek M. Shore, Mariam M. Mahmoud, Teresa Olszewska
Publikováno v:
Molecular Pharmacology. 87:197-206
Some inverse agonists of cannabinoid receptor type 1 (CB1) have been demonstrated to be anorectic antiobesity drug candidates. However, the first generation of CB1 inverse agonists, represented by rimonabant (SR141716A), otenabant, and taranabant, ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe94322ce9e6360033182c04781b6d26
https://doi.org/10.1124/mol.114.095471
https://doi.org/10.1124/mol.114.095471
Publikováno v:
Journal of Biological Chemistry. 288:9790-9800
The cannabinoid receptor 1 (CB1) is a G protein-coupled receptor primarily expressed in brain tissue that has been implicated in several disease states. CB1 allosteric compounds, such as ORG27569, offer enormous potential as drugs over orthosteric li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53400bf5ef8b42fc70be761b678ecea3
https://doi.org/10.1074/jbc.m112.438804
https://doi.org/10.1074/jbc.m112.438804
Publikováno v:
Journal of Neurochemistry. 124:584-589
Allosteric modulation of G-protein coupled receptors (GPCRs) represents a novel approach for fine-tuning GPCR functions. The cannabinoid CB1 receptor, a GPCR associated with the CNS, has been implicated in the treatment of drug addiction, pain, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5196792e8dfcd1f4fb0847746a67ace3
https://doi.org/10.1111/jnc.12115
https://doi.org/10.1111/jnc.12115