Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mariam M Konaté"'
Autor:
Jiamo Lu, Guojian Jiang, Yongzhong Wu, Smitha Antony, Jennifer L Meitzler, Agnes Juhasz, Han Liu, Krishnendu Roy, Hala Makhlouf, Rodrigo Chuaqui, Donna Butcher, Mariam M Konaté, James H Doroshow
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233208 (2020)
To facilitate functional investigation of the role of NADPH oxidase 1 (NOX1) and associated reactive oxygen species in cancer cell signaling, we report herein the development and characterization of a novel mouse monoclonal antibody that specifically
Externí odkaz:
https://doaj.org/article/ebb8d7dabc614df08b60c032e03783fa
Publikováno v:
eLife, Vol 8 (2019)
Functional conservation is known to constrain protein evolution. Nevertheless, the long-term divergence patterns of proteins maintaining the same molecular function and the possible limits of this divergence have not been explored in detail. We inves
Externí odkaz:
https://doaj.org/article/f05496596e4847a6ac2c657d10d65cf6
Autor:
Mariam M. Konaté, Julia Krushkal, Ming-Chung Li, Li Chen, Yuri Kotliarov, Alida Palmisano, Rini Pauly, Qian Xie, P. Mickey Williams, Lisa M. McShane, Yingdong Zhao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background With poor prognosis and high mortality, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Standard of care therapies for PDAC have included gemcitabine for the past three decades, although resistance
Externí odkaz:
https://doaj.org/article/8450290fb1bd45a187afecbd4534732f
Autor:
James H. Doroshow, Richard Simon, Beverly A. Teicher, Annamaria Rapisarda, John W. Connelly, Xiaolin Wu, Erik Harris, Ming-Chung Li, Andrea Regier Voth, Melanie A. Simpson, Sarah B. Miller, Mariam M. Konaté, Laura K. Fogli, Eric C. Polley, Alida Palmisano, Dmitriy Sonkin, Jianwen Fang, Julia Krushkal, Hossein Hamed, Curtis Hose, Yingdong Zhao, Anne Monks
This file contains Supplementary Figure S1 (Correlation between downregulation of EGFR transcriptional target genes, and sensitivity to erlotinib at the high concentration after 6 hours); Supplementary Figure S2 (EGFR inhibitor and DNA damaging agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc993771930d8a7ddbff3301672bc8f
https://doi.org/10.1158/0008-5472.22419693.v1
https://doi.org/10.1158/0008-5472.22419693.v1
Autor:
James H. Doroshow, Richard Simon, Beverly A. Teicher, Annamaria Rapisarda, John W. Connelly, Xiaolin Wu, Erik Harris, Ming-Chung Li, Andrea Regier Voth, Melanie A. Simpson, Sarah B. Miller, Mariam M. Konaté, Laura K. Fogli, Eric C. Polley, Alida Palmisano, Dmitriy Sonkin, Jianwen Fang, Julia Krushkal, Hossein Hamed, Curtis Hose, Yingdong Zhao, Anne Monks
The intracellular effects and overall efficacies of anticancer therapies can vary significantly by tumor type. To identify patterns of drug-induced gene modulation that occur in different cancer cell types, we measured gene-expression changes across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c547975162ffcae835aa494f5df13e
https://doi.org/10.1158/0008-5472.c.6510450
https://doi.org/10.1158/0008-5472.c.6510450
Publikováno v:
Scientific Reports. 12
Proteomic data provide a direct readout of protein function, thus constituting an information-rich resource for prognostic and predictive modeling. However, protein array data may not fully capture pathway activity due to the limited number of molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6a1b4b1da5f1140c32bfa3f384f3af
https://doi.org/10.1038/s41598-022-23693-w
https://doi.org/10.1038/s41598-022-23693-w
Publikováno v:
Antioxid Redox Signal
Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX-associated ROS can promote oxidative stress, aberrant signaling, and genomic instabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c402d5c911564e5625073871974e6d
https://doi.org/10.1089/ars.2020.8046
https://doi.org/10.1089/ars.2020.8046
Autor:
Li Chen, Rodrigo F. Chuaqui, Sarah B. Miller, Jyothi Subramanian, Larry Rubinstein, Robert J. Kinders, Andrea Regier Voth, Scott M. Lawrence, Apurva K. Srivastava, Tony Navas, Melinda G. Hollingshead, Shivaani Kummar, Hala R. Makhlouf, Katherine V. Ferry-Galow, James H. Doroshow, Ralph E. Parchment, Alice P. Chen, Deborah Wilsker, Mariam M. Konaté, Sergio Y. Alcoser, Suzanne Borgel, Tomas Vilimas, Donald P. Bottaro
Publikováno v:
Cancer Res
The significance of the phenotypic plasticity afforded by epithelial–mesenchymal transition (EMT) for cancer progression and drug resistance remains to be fully elucidated in the clinic. We evaluated epithelial–mesenchymal phenotypic characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59338eb3b09922b809c69cf33ae0f4a4
https://doi.org/10.1158/0008-5472.can-18-3539
https://doi.org/10.1158/0008-5472.can-18-3539
Autor:
Yongzhong Wu, Mariam M. Konaté, Melinda Hollingshead, Baktiar Karim, Becky Diebold, Jiamo Lu, Smitha Antony, Jennifer L. Meitzler, Agnes Juhasz, Guojian Jiang, Iris Dahan, Krishnendu Roy, James H. Doroshow
Previously, we demonstrated that pro-inflammatory cytokines enhance dual oxidase 2 (DUOX2)-dependent production of reactive oxygen species by human pancreatic ductal carcinoma (PDAC) cells, and that DUOX2 expression is significantly increased in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc3c770f5621f8774991ca4e6177720b
https://doi.org/10.1101/2022.02.13.480277
https://doi.org/10.1101/2022.02.13.480277
Autor:
Iris Dahan, Guojian Jiang, Rodrigo F. Chuaqui, Yongzhong Wu, James H. Doroshow, Michael J. Difilippantonio, Jiamo Lu, Smitha Antony, Krishnendu Roy, Jennifer L. Meitzler, Han Liu, Mariam M. Konaté, Hala R. Makhlouf, Agnes Juhasz
Publikováno v:
The Journal of Immunology. 203:2532-2544
Dual oxidase 2 (DUOX2) generates H2O2 that plays a critical role in both host defense and chronic inflammation. Previously, we demonstrated that the proinflammatory mediators IFN-γ and LPS enhance expression of DUOX2 and its maturation factor DUOXA2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97af94db5fcf49af3896d953fbd9fd2
https://doi.org/10.4049/jimmunol.1800469
https://doi.org/10.4049/jimmunol.1800469