Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mariam Jouni"'
Autor:
K. Ashley Fetterman, Malorie Blancard, Davi M. Lyra-Leite, Carlos G. Vanoye, Hananeh Fonoudi, Mariam Jouni, Jean-Marc L. DeKeyser, Brian Lenny, Yadav Sapkota, Alfred L. George, Jr., Paul W. Burridge
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114160- (2024)
Summary: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) recapitulate numerous disease and drug response phenotypes, but cell immaturity may limit their accuracy and fidelity as a model system. Cell culture medium modification
Externí odkaz:
https://doaj.org/article/df419155f7fa4cacb87f83b0c98d9bc2
Autor:
Purnima Singh, Liting Zhou, Disheet A. Shah, Romina B. Cejas, David K. Crossman, Mariam Jouni, Tarek Magdy, Xuexia Wang, Noha Sharafeldin, Lindsey Hageman, Donald E. McKenna, Steve Horvath, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A. Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Paul W. Burridge, Smita Bhatia
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Anthracycline-induced cardiomyopathy is a leading cause of late morbidity in childhood cancer survivors. Aberrant DNA methylation plays a role in de novo cardiovascular disease. Epigenetic processes could play a role in anthracycline-induced
Externí odkaz:
https://doaj.org/article/5acaf1b97f694d69939aaf30a6003783
Autor:
Purnima Singh, Disheet A. Shah, Mariam Jouni, Romina B. Cejas, David K. Crossman, Tarek Magdy, Shaowei Qiu, Xuexia Wang, Liting Zhou, Noha Sharafeldin, Lindsey Hageman, Donald E. McKenna, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Ravi Bhatia, Paul W. Burridge, Smita Bhatia
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background Anthracycline‐induced cardiomyopathy is a leading cause of premature death in childhood cancer survivors, presenting a need to understand the underlying pathogenesis. We sought to examine differential blood‐based mRNA expression profil
Externí odkaz:
https://doaj.org/article/f8f46a7b0c144ebca9495b274983c0e1
Autor:
Rasha Al-attar, Joseph Jargstorf, Rocco Romagnuolo, Mariam Jouni, Faisal J. Alibhai, Paul D. Lampe, Joell L. Solan, Michael A. Laflamme
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 61 (2024)
The transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has shown promise in preclinical models of myocardial infarction, but graft myocardium exhibits incomplete host–graft electromechanical integration and a propensit
Externí odkaz:
https://doaj.org/article/78cf26346a0b476b8ceddafac10f4217
Autor:
Hui-Hsuan Kuo, Xiaozhi Gao, Jean-Marc DeKeyser, K. Ashley Fetterman, Emily A. Pinheiro, Carly J. Weddle, Hananeh Fonoudi, Michael V. Orman, Marisol Romero-Tejeda, Mariam Jouni, Malorie Blancard, Tarek Magdy, Conrad L. Epting, Alfred L. George, Jr., Paul W. Burridge
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 256-270 (2020)
Summary: Human induced pluripotent stem cell (hiPSC) culture has become routine, yet the cost of pluripotent cell media, frequent medium changes, and the reproducibility of differentiation have remained restrictive. Here, we describe the formulation
Externí odkaz:
https://doaj.org/article/02ff6b71bbf049cbb92ceee86f3339ee
Autor:
Zeina R. Al Sayed, Mariam Jouni, Jean‐Baptiste Gourraud, Nadjet Belbachir, Julien Barc, Aurore Girardeau, Virginie Forest, Aude Derevier, Anne Gaignerie, Caroline Chariau, Bastien Cimarosti, Robin Canac, Pierre Olchesqui, Eric Charpentier, Jean‐Jacques Schott, Richard Redon, Isabelle Baró, Vincent Probst, Flavien Charpentier, Gildas Loussouarn, Kazem Zibara, Guillaume Lamirault, Patricia Lemarchand, Nathalie Gaborit
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/2317e090f55f4c2ab06747c2064a68e2
Autor:
Tarek Magdy, Mariam Jouni, Hui-Hsuan Kuo, Carly J. Weddle, Davi Lyra-Leite, Hananeh Fonoudi, Marisol Romero-Tejeda, Mennat Gharib, Hoor Javed, Giovanni Fajardo, Colin J.D. Ross, Bruce C. Carleton, Daniel Bernstein, Paul W. Burridge
Publikováno v:
Circulation. 145:279-294
Background: Multiple pharmacogenomic studies have identified the synonymous genomic variant rs7853758 (G > A, L461L) and the intronic variant rs885004 in SLC28A3 (solute carrier family 28 member 3) as statistically associated with a lower incidence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2e1d7d7e9fec71b08d4f4bc1a69b7a
https://doi.org/10.1161/circulationaha.121.055801
https://doi.org/10.1161/circulationaha.121.055801
Autor:
K. Ashley Fetterman, Malorie Blancard, Mariam Jouni, Franck Potet, Gregory G Webster, Alfred L George, Paul W Burridge
Publikováno v:
Circulation Research. 131
Calmodulinopathy is a life-threatening cardiac arrhythmia syndrome resulting from a single heterozygous mutation in any of the three calmodulin (CaM) genes. Most (68%) persons with a pathogenic CaM variant will experience a major arrhythmic event suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c36340bcc494f3b3bb5fc02b8c6588c
https://doi.org/10.1161/res.131.suppl_1.p2105
https://doi.org/10.1161/res.131.suppl_1.p2105
Autor:
Alejandra Leo-Macias, Mingliang Zhang, Marta Pérez-Hernández, Paul W. Burridge, Feng-Xia Liang, Mario Delmar, Sarah Keegan, Joon Chul Kim, David Fenyö, Esperanza Agullo-Pascual, Eli Rothenberg, Mariam Jouni, Sarah H. Vermij
Publikováno v:
Circulation Research. 128:419-432
Rationale: The cardiac sodium channel Na V 1.5 has a fundamental role in excitability and conduction. Previous studies have shown that sodium channels cluster together in specific cellular subdomains. Their association with intracellular organelles i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::835a48d70a860f85e6d5a27261415864
https://doi.org/10.1161/circresaha.120.318239
https://doi.org/10.1161/circresaha.120.318239
Autor:
Daniel Bernstein, Colin J. D. Ross, Yadav Sapkota, Mariam Jouni, Hananeh Fonoudi, Gwanghyun Jung, Marisol Romero-Tejeda, Mingming Zhao, Bruce Carleton, Mennat Gharib, Zhengxin Jiang, Davi M. Lyra-Leite, Hui Hsuan Kuo, Brian T. Burmeister, K. Ashley Fetterman, Tarek Magdy, Paul W. Burridge
Publikováno v:
Cell Stem Cell
Summary Doxorubicin is an anthracycline chemotherapy agent effective in treating a wide range of malignancies, but its use is limited by dose-dependent cardiotoxicity. A recent genome-wide association study identified a SNP (rs2229774) in retinoic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620dbfebc74c747052a00af3d10ee6f8
https://pubmed.ncbi.nlm.nih.gov/34861143
https://pubmed.ncbi.nlm.nih.gov/34861143