Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Mariam G. Aslanyan"'
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Akademický článek
A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome
Autor: Mariam G. Aslanyan, Cenna Doornbos, Gaurav D. Diwan, Zeinab Anvarian, Tina Beyer, Katrin Junger, Sylvia E. C. van Beersum, Robert B. Russell, Marius Ueffing, Alexander Ludwig, Karsten Boldt, Lotte B. Pedersen, Ronald Roepman
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Establishment and maintenance of the primary cilium as a signaling-competent organelle requires a high degree of fine tuning, which is at least in part achieved by a variety of post-translational modifications. One such modification is ubiquitination
Externí odkaz: https://doaj.org/article/763fbe7f15ec459a96e34a2a65158816
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2
Akademický článek
Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction.
Autor: Dov Tiosano, Hagit N Baris, Anlu Chen, Marrit M Hitzert, Markus Schueler, Federico Gulluni, Antje Wiesener, Antonio Bergua, Adi Mory, Brett Copeland, Joseph G Gleeson, Patrick Rump, Hester van Meer, Deborah A Sival, Volker Haucke, Josh Kriwinsky, Karl X Knaup, André Reis, Nadine N Hauer, Emilio Hirsch, Ronald Roepman, Rolph Pfundt, Christian T Thiel, Michael S Wiesener, Mariam G Aslanyan, David A Buchner
Publikováno v: PLoS Genetics, Vol 15, Iss 4, p e1008088 (2019)
PIK3C2A is a class II member of the phosphoinositide 3-kinase (PI3K) family that catalyzes the phosphorylation of phosphatidylinositol (PI) into PI(3)P and the phosphorylation of PI(4)P into PI(3,4)P2. At the cellular level, PIK3C2A is critical for t
Externí odkaz: https://doaj.org/article/53593e35407b4010bb8e4e02f0479df0
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3
Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction
Autor: Hester van Meer, Adi Mory, Anlu Chen, Mariam G Aslanyan, David A. Buchner, Volker Haucke, Antonio Bergua, Hagit N. Baris, Joseph G. Gleeson, Marrit M. Hitzert, Dov Tiosano, Christian Thiel, André Reis, Ronald Roepman, Emilio Hirsch, Patrick Rump, Deborah A Sival, Nadine N. Hauer, Karl X. Knaup, Brett Copeland, Josh Kriwinsky, Antje Wiesener, Federico Gulluni, Rolph Pfundt, Markus Schueler, Michael S. Wiesener
Publikováno v: PLoS genetics, 15(4):1008088. PUBLIC LIBRARY SCIENCE
PLoS Genetics
PLoS Genetics, Vol 15, Iss 4, p e1008088 (2019)
Plos Genetics, 15
Plos Genetics, 15, 4
PIK3C2A is a class II member of the phosphoinositide 3-kinase (PI3K) family that catalyzes the phosphorylation of phosphatidylinositol (PI) into PI(3)P and the phosphorylation of PI(4)P into PI(3,4)P2. At the cellular level, PIK3C2A is critical for t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54ae955c0dc596f39c8afe4bc7e8ccd
https://research.rug.nl/en/publications/e8bcbfcf-80aa-4dff-be70-663326dd7e38
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4
Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial
Autor: Roel Willemze, Mariam G Aslanyan, Sergio Amadori, Petra Muus, Leonie I. Kroeze, Evelyn Tönnissen, Pedro da Silva-Coelho, Jean-Pierre Marie, Stefan Suciu, Marion Massop, Theresia N. Koorenhof-Scheele, Erik W.A. Marijt, Adrian van der Heijden, Louis van de Locht, Saskia Langemeijer, Ellen Stevens-Linders, Giuseppe Saglio, Ruoping Tang, Bert A. van der Reijden, Patricia van Hoogen, Daniela Cilloni, Boris Labar, Theo de Witte, Joop H. Jansen
Publikováno v: Annals of Hematology, 93, 8, pp. 1401-12
Annals of Hematology, 93, 1401-12
Annals of Hematology, 93(8), 1401-1412
Item does not contain fulltext We assessed the prognostic impact of TET2 mutations and mRNA expression in a prospective cohort of 357 adult AML patients < 60 years of age enrolled in the European Organization For Research and Treatment of Cancer (EOR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7838d5fd4f1a4334a7bf1665ad4aeb3c
https://hdl.handle.net/2066/137635
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5
Acquired mutations in TET2 are common in myelodysplastic syndromes
Autor: Marieke Berends, Anne Hagemeijer, Gregor Verhoef, Ruth Knops, Joop H. Jansen, Patricia van Hoogen, Saskia Langemeijer, Peter Vandenberghe, Mariam G Aslanyan, Ellen Stevens-Linders, Theo de Witte, Reinier Raymakers, Roland P. Kuiper, Marion Massop, E Verburgh, Eveline J. Kamping, Bert A. van der Reijden, Ad Geurts van Kessel
Publikováno v: Nature Genetics, 41, 7, pp. 838-42
Nature Genetics, 41, 838-42
Contains fulltext : 79550.pdf (Publisher’s version ) (Closed access) Myelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic hematopoietic disorders. Several recurrent chromosomal aberrations have been associated with MDS, but
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b591b16f6fad5a6a64f66b665fb23a85
https://doi.org/10.1038/ng.391
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6
The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically
Autor: Ronald Roepman, Uwe Wolfrum, Lisette Hetterschijt, Mariam G Aslanyan, Erwin van Wijk, Bert van der Zwaag, Jan E.E. Keunen, Hannie Kremer, Theo A. Peters, Ferry F.J. Kersten, Katharina Bauβ
Publikováno v: Cilia, 1, 12-12
Cilia, 1, 2, pp. 12-12
Cilia
Cilia, Vol 1, Iss 1, p 2 (2012)
Cilia; Vol 1
Background Mutations in the gene for Usher syndrome 2A (USH2A) are causative for non-syndromic retinitis pigmentosa and Usher syndrome, a condition that is the most common cause of combined deaf-blindness. To gain insight into the molecular pathology
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c376da673affab7db8b6e7c8766395
http://hdl.handle.net/2066/109883
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7
TET proteins in malignant hematopoiesis
Autor: Saskia Langemeijer, Mariam G Aslanyan, Joop H. Jansen
Publikováno v: Cell Cycle, 8, 4044-8
Cell Cycle, 8, 24, pp. 4044-8
Differentiation of hematopoietic stem cells into mature blood cells is a multistage process. During each stage, both extrinsic and intrinsic factors coordinate the expression of the genes required for the cell to adopt a particular fate. Disturbance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbbabe5966ca8cb60c5c2ee2cc057d1
http://hdl.handle.net/2066/81442
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9
Aberrant 5-Hydroxymethylcytosine Levels Correlate With Poor Overall Survival In Acute Myeloid Leukemia
Autor: Leonie I Kroeze, Mariam G Aslanyan, Arno van Rooij, Theresia N Koorenhof-Scheele, Marion Massop, Thomas Carell, Jan B Boezeman, Jean-Pierre Marie, Constantijn J.M. Halkes, Theo M. de Witte, Gerwin Huls, Stefan Suciu, Ron Wevers, Bert A. van der Reijden, Joop H. Jansen
Publikováno v: Blood. 122:1261-1261
Background Patients with acute myeloid leukemia (AML) frequently harbor mutations in genes involved in the DNA (hydroxy)methylation pathway (DNMT3A, TET2, IDH1, and IDH2). In addition, changes in DNA methylation have been implicated in the pathogenes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35cf54569144fd4be4ee3af00ca7dcb4
https://doi.org/10.1182/blood.v122.21.1261.1261
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